Evolution of a General RNA-Cleaving FANA Enzyme

Artificial genetic polymers (XNAs) have been explored for their nuclease activity, but XNAzymes have proven challenging to discover by in vitro selection. Here, the authors generate an efficient RNA-cleaving 2’-fluoroarabino nucleic acid enzyme (FANAzyme) by in vitro evolution using natural DNA poly...

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Autores principales:	Yajun Wang, Arlene K. Ngor, Ali Nikoomanzar, John C. Chaput
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/596b420be50f478c8b1343b5a6191768
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id	oai:doaj.org-article:596b420be50f478c8b1343b5a6191768
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spelling	oai:doaj.org-article:596b420be50f478c8b1343b5a61917682021-12-02T16:49:52ZEvolution of a General RNA-Cleaving FANA Enzyme10.1038/s41467-018-07611-12041-1723https://doaj.org/article/596b420be50f478c8b1343b5a61917682018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07611-1https://doaj.org/toc/2041-1723Artificial genetic polymers (XNAs) have been explored for their nuclease activity, but XNAzymes have proven challenging to discover by in vitro selection. Here, the authors generate an efficient RNA-cleaving 2’-fluoroarabino nucleic acid enzyme (FANAzyme) by in vitro evolution using natural DNA polymerases.Yajun WangArlene K. NgorAli NikoomanzarJohn C. ChaputNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yajun Wang Arlene K. Ngor Ali Nikoomanzar John C. Chaput Evolution of a General RNA-Cleaving FANA Enzyme
description	Artificial genetic polymers (XNAs) have been explored for their nuclease activity, but XNAzymes have proven challenging to discover by in vitro selection. Here, the authors generate an efficient RNA-cleaving 2’-fluoroarabino nucleic acid enzyme (FANAzyme) by in vitro evolution using natural DNA polymerases.
format	article
author	Yajun Wang Arlene K. Ngor Ali Nikoomanzar John C. Chaput
author_facet	Yajun Wang Arlene K. Ngor Ali Nikoomanzar John C. Chaput
author_sort	Yajun Wang
title	Evolution of a General RNA-Cleaving FANA Enzyme
title_short	Evolution of a General RNA-Cleaving FANA Enzyme
title_full	Evolution of a General RNA-Cleaving FANA Enzyme
title_fullStr	Evolution of a General RNA-Cleaving FANA Enzyme
title_full_unstemmed	Evolution of a General RNA-Cleaving FANA Enzyme
title_sort	evolution of a general rna-cleaving fana enzyme
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/596b420be50f478c8b1343b5a6191768
work_keys_str_mv	AT yajunwang evolutionofageneralrnacleavingfanaenzyme AT arlenekngor evolutionofageneralrnacleavingfanaenzyme AT alinikoomanzar evolutionofageneralrnacleavingfanaenzyme AT johncchaput evolutionofageneralrnacleavingfanaenzyme
_version_	1718383159941267456

Evolution of a General RNA-Cleaving FANA Enzyme

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