Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia

Abstract Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. genitalium transmission in MSM is unclear. We created four deterministic susceptible-infectious...

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Autores principales:	Xianglong Xu, Catriona S. Bradshaw, Eric P. F. Chow, Jason J. Ong, Jane S. Hocking, Christopher K. Fairley, Lei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/596d3195d4474448af0225cf6dbb9c39
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spelling	oai:doaj.org-article:596d3195d4474448af0225cf6dbb9c392021-12-02T16:53:01ZModelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia10.1038/s41598-021-90627-32045-2322https://doaj.org/article/596d3195d4474448af0225cf6dbb9c392021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90627-3https://doaj.org/toc/2045-2322Abstract Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. genitalium transmission in MSM is unclear. We created four deterministic susceptible-infectious-susceptible epidemic models to examine the role that different sexual behaviours play in transmitting M. genitalium at the oropharynx, urethra anorectum among men who have sex with men in Australia. Our results suggest that oral and anal sex without other sexual practices (model 1) replicate well single site infection at the oropharynx, urethra and anorectum and also multi-site infection. If kissing or rimming are added to model 1 (i.e., model 2–4) no substantial improvements in the calibration of the models occur. Model 1 estimates that 3.4% of infections occur at the oropharynx, 34.8% at the urethra and 61.8% at the anorectum. Model 1 also estimates that the proportion of incident M. genitalium transmitted by anal sex was 82.4%, and by oral sex was about 17.6%. Our findings could provide an enhanced understanding of M. genitalium transmission in MSM, thus providing insights into what sexual practices contribute most to transmission.Xianglong XuCatriona S. BradshawEric P. F. ChowJason J. OngJane S. HockingChristopher K. FairleyLei ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xianglong Xu Catriona S. Bradshaw Eric P. F. Chow Jason J. Ong Jane S. Hocking Christopher K. Fairley Lei Zhang Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
description	Abstract Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. genitalium transmission in MSM is unclear. We created four deterministic susceptible-infectious-susceptible epidemic models to examine the role that different sexual behaviours play in transmitting M. genitalium at the oropharynx, urethra anorectum among men who have sex with men in Australia. Our results suggest that oral and anal sex without other sexual practices (model 1) replicate well single site infection at the oropharynx, urethra and anorectum and also multi-site infection. If kissing or rimming are added to model 1 (i.e., model 2–4) no substantial improvements in the calibration of the models occur. Model 1 estimates that 3.4% of infections occur at the oropharynx, 34.8% at the urethra and 61.8% at the anorectum. Model 1 also estimates that the proportion of incident M. genitalium transmitted by anal sex was 82.4%, and by oral sex was about 17.6%. Our findings could provide an enhanced understanding of M. genitalium transmission in MSM, thus providing insights into what sexual practices contribute most to transmission.
format	article
author	Xianglong Xu Catriona S. Bradshaw Eric P. F. Chow Jason J. Ong Jane S. Hocking Christopher K. Fairley Lei Zhang
author_facet	Xianglong Xu Catriona S. Bradshaw Eric P. F. Chow Jason J. Ong Jane S. Hocking Christopher K. Fairley Lei Zhang
author_sort	Xianglong Xu
title	Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
title_short	Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
title_full	Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
title_fullStr	Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
title_full_unstemmed	Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
title_sort	modelling the multiple anatomical site transmission of mycoplasma genitalium among men who have sex with men in australia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/596d3195d4474448af0225cf6dbb9c39
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Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia

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