Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials

Zhen Du,1 Yuewei Li,1 Jinwei Li,1 Changli Zhou,1 Feng Li,1,* Xige Yang2,* 1Department of Internal Nursing, School of Nursing, Jilin University, Changchun, Jilin, 130020, People’s Republic of China; 2Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, 13...

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Autores principales: Du Z, Li YW, Li JW, Zhou CL, Li F, Yang XG
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:597332ce245c4c1598133f215d1412d32021-12-02T03:34:25ZPhysical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials1178-1998https://doaj.org/article/597332ce245c4c1598133f215d1412d32018-09-01T00:00:00Zhttps://www.dovepress.com/physical-activity-can-improve-cognition-in-patients-with-alzheimers-di-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhen Du,1 Yuewei Li,1 Jinwei Li,1 Changli Zhou,1 Feng Li,1,* Xige Yang2,* 1Department of Internal Nursing, School of Nursing, Jilin University, Changchun, Jilin, 130020, People’s Republic of China; 2Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, 130021, People’s Republic of China *These authors contributed equally to this work Background/objective: Alzheimer’s disease (AD) is mainly characterized by decline of cognitive functions such as memory and learning, which has a high prevalence and poor drug efficacy in treatment regimes. A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to evaluate the effectiveness of exercise on cognitive function in patients diagnosed with AD.Methods: The bibliographic databases (PubMed, Cochrane Library and Embase, and Web of Science) and four Chinese databases (Wanfang data, CBM, CNKI, and VIP) were searched to identify RCTs published in any language between January 1, 1960, and January 1, 2018. Only peer-reviewed articles and RCTs were included. The collected data were analyzed by Review Manager (5.3).Results: Overall, 869 patients diagnosed with AD were included from 13 RCTs. Patients in the intervention group received pure exercise interventions and a cognitive test. Although there was heterogeneity in intervention methods and cognitive measures among studies, meta-analysis (seven studies) supports positive effects of physical activity on cognitive function of patients with AD (mean difference [MD] =2.53, the 95% CI=0.84 to 4.22, test for overall effect: Z=2.93 [P=0.003]). Eight studies demonstrated that exercise improves cognitive function for individuals with AD. However, the remaining five studies did not display a beneficial effect of exercise on cognitive function in patients with AD.Conclusion: This meta-analysis and systematic review indicated that exercise intervention might improve the cognitive function of AD or slow down the decline of cognition; however, this relationship was not always true across studies. RCTs with clear intervention criteria, large samples, and long-term follow-up are needed in the future to demonstrate the benefits of exercise for cognitive function in AD patients. Keywords: Alzheimer’s disease, exercise, cognitive function, randomized controlled trialDu ZLi YWLi JWZhou CLLi FYang XGDove Medical PressarticleAlzheimer's disease (AD)exercisecognitive functionrandomized controlled trial (RCT)GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1593-1603 (2018)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer's disease (AD)
exercise
cognitive function
randomized controlled trial (RCT)
Geriatrics
RC952-954.6
spellingShingle Alzheimer's disease (AD)
exercise
cognitive function
randomized controlled trial (RCT)
Geriatrics
RC952-954.6
Du Z
Li YW
Li JW
Zhou CL
Li F
Yang XG
Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
description Zhen Du,1 Yuewei Li,1 Jinwei Li,1 Changli Zhou,1 Feng Li,1,* Xige Yang2,* 1Department of Internal Nursing, School of Nursing, Jilin University, Changchun, Jilin, 130020, People’s Republic of China; 2Department of Anesthesiology, The First Hospital of Jilin University, Changchun, Jilin, 130021, People’s Republic of China *These authors contributed equally to this work Background/objective: Alzheimer’s disease (AD) is mainly characterized by decline of cognitive functions such as memory and learning, which has a high prevalence and poor drug efficacy in treatment regimes. A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to evaluate the effectiveness of exercise on cognitive function in patients diagnosed with AD.Methods: The bibliographic databases (PubMed, Cochrane Library and Embase, and Web of Science) and four Chinese databases (Wanfang data, CBM, CNKI, and VIP) were searched to identify RCTs published in any language between January 1, 1960, and January 1, 2018. Only peer-reviewed articles and RCTs were included. The collected data were analyzed by Review Manager (5.3).Results: Overall, 869 patients diagnosed with AD were included from 13 RCTs. Patients in the intervention group received pure exercise interventions and a cognitive test. Although there was heterogeneity in intervention methods and cognitive measures among studies, meta-analysis (seven studies) supports positive effects of physical activity on cognitive function of patients with AD (mean difference [MD] =2.53, the 95% CI=0.84 to 4.22, test for overall effect: Z=2.93 [P=0.003]). Eight studies demonstrated that exercise improves cognitive function for individuals with AD. However, the remaining five studies did not display a beneficial effect of exercise on cognitive function in patients with AD.Conclusion: This meta-analysis and systematic review indicated that exercise intervention might improve the cognitive function of AD or slow down the decline of cognition; however, this relationship was not always true across studies. RCTs with clear intervention criteria, large samples, and long-term follow-up are needed in the future to demonstrate the benefits of exercise for cognitive function in AD patients. Keywords: Alzheimer’s disease, exercise, cognitive function, randomized controlled trial
format article
author Du Z
Li YW
Li JW
Zhou CL
Li F
Yang XG
author_facet Du Z
Li YW
Li JW
Zhou CL
Li F
Yang XG
author_sort Du Z
title Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
title_short Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
title_full Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
title_fullStr Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
title_full_unstemmed Physical activity can improve cognition in patients with Alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
title_sort physical activity can improve cognition in patients with alzheimer’s disease: a systematic review and meta-analysis of randomized controlled trials
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/597332ce245c4c1598133f215d1412d3
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