Universal Vaccines: Shifting to One for Many

ABSTRACT Human vaccines, with their exquisite antigenic specificity, have greatly helped to eliminate or dramatically abate the incidence of a number of historical and current plagues, from smallpox to bacterial meningitis. Nonetheless, as new infectious agents emerge and the number of vaccine-preve...

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Autores principales:	Antonio Cassone, Rino Rappuoli
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2010
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/597629fa10604992a070abcd836d49e4
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spelling	oai:doaj.org-article:597629fa10604992a070abcd836d49e42021-11-15T15:38:14ZUniversal Vaccines: Shifting to One for Many10.1128/mBio.00042-102150-7511https://doaj.org/article/597629fa10604992a070abcd836d49e42010-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00042-10https://doaj.org/toc/2150-7511ABSTRACT Human vaccines, with their exquisite antigenic specificity, have greatly helped to eliminate or dramatically abate the incidence of a number of historical and current plagues, from smallpox to bacterial meningitis. Nonetheless, as new infectious agents emerge and the number of vaccine-preventable diseases increases, the practice and benefits of single-pathogen- or disease-targeted vaccination may be put at risk by constraints of timely production, formulation complexity, and regulatory hurdles. During the last influenza pandemic, extraordinary efforts by vaccine producers and health authorities have had little or no influence on disease prevention or mitigation. Recent research demonstrating the possibility of protecting against all influenza A virus types or even phylogenetically distant pathogens with vaccines based on highly conserved peptide or saccharide sequences is changing our paradigm. “Universal vaccine” strategies could be particularly advantageous to address protection from antibiotic-resistant bacteria and fungi for which no vaccine is currently available.Antonio CassoneRino RappuoliAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 1, Iss 1 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Antonio Cassone Rino Rappuoli Universal Vaccines: Shifting to One for Many
description	ABSTRACT Human vaccines, with their exquisite antigenic specificity, have greatly helped to eliminate or dramatically abate the incidence of a number of historical and current plagues, from smallpox to bacterial meningitis. Nonetheless, as new infectious agents emerge and the number of vaccine-preventable diseases increases, the practice and benefits of single-pathogen- or disease-targeted vaccination may be put at risk by constraints of timely production, formulation complexity, and regulatory hurdles. During the last influenza pandemic, extraordinary efforts by vaccine producers and health authorities have had little or no influence on disease prevention or mitigation. Recent research demonstrating the possibility of protecting against all influenza A virus types or even phylogenetically distant pathogens with vaccines based on highly conserved peptide or saccharide sequences is changing our paradigm. “Universal vaccine” strategies could be particularly advantageous to address protection from antibiotic-resistant bacteria and fungi for which no vaccine is currently available.
format	article
author	Antonio Cassone Rino Rappuoli
author_facet	Antonio Cassone Rino Rappuoli
author_sort	Antonio Cassone
title	Universal Vaccines: Shifting to One for Many
title_short	Universal Vaccines: Shifting to One for Many
title_full	Universal Vaccines: Shifting to One for Many
title_fullStr	Universal Vaccines: Shifting to One for Many
title_full_unstemmed	Universal Vaccines: Shifting to One for Many
title_sort	universal vaccines: shifting to one for many
publisher	American Society for Microbiology
publishDate	2010
url	https://doaj.org/article/597629fa10604992a070abcd836d49e4
work_keys_str_mv	AT antoniocassone universalvaccinesshiftingtooneformany AT rinorappuoli universalvaccinesshiftingtooneformany
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Universal Vaccines: Shifting to One for Many

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