Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.

<h4>Background</h4>Guangxi has become one of the provinces with the most severe HIV-1 epidemic in China, where heterosexual contact is the dominant transmission route. However, data of acute HIV infections and HIV incidence among female sex workers (FSWs) from low-grade venues are scant....

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Autores principales:	Jianjun Li, Hongman Zhang, Zhiyong Shen, Yuejiao Zhou, Ningye Fang, Lu Wang, Bin Wang, Jiangwei Wang, Zhenzhu Tang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/597694a3d5364a63a0e5ca51039e6279
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spelling	oai:doaj.org-article:597694a3d5364a63a0e5ca51039e62792021-11-18T08:16:10ZScreening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.1932-620310.1371/journal.pone.0099522https://doaj.org/article/597694a3d5364a63a0e5ca51039e62792014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24918933/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Guangxi has become one of the provinces with the most severe HIV-1 epidemic in China, where heterosexual contact is the dominant transmission route. However, data of acute HIV infections and HIV incidence among female sex workers (FSWs) from low-grade venues are scant.<h4>Methods</h4>A cross-sectional survey was performed among FSWs from low-grade venues in Guangxi. HIV antibody screening was performed by rapid testing (RT). HIV antibody-negative specimens were screened by pooled nucleic acid amplification testing (NAAT) for acute HIV infections. HIV antibody-positive specimens were further analyzed by Western blot (WB), followed by an HIV-1 BED capture enzyme immunoassay (BED-CEIA) to identify the recent infections. HIV-1 incidence was estimated by the data of pooled NAAT and BED-CEIA, respectively.<h4>Results</h4>A total of 7936 FSWs were recruited and answered the questionnaires. We successfully collected the blood samples from 6469 (81.5%) participants, of which 139 (2.1%) were HIV antibody-positive and 6330 (97.9%) were HIV antibody-negative by RT. With pooled NAAT, 7 cases were found to be HIV RNA positive, representing an additional 5.0% of HIV-infected persons and an estimated HIV incidence of 1.45 (95% CI: 1.17-1.76) per 100 person years. There were 137 positive and 2 indeterminate by WB, of which 124 (90.5%) positive specimens were subjected to BED-CEIA testing identifying 28 recent infections. The HIV incidence determined by BED-CEIA testing was 1.04 (95% CI: 0.65-1.43) per 100 person years. The overall prevalence of HIV among FSWs from low-grade venues in Guangxi was 2.2% (95% CI: 1.9-2.6).<h4>Conclusions</h4>We found that the addition of HIV RNA screening to routine HIV antibody testing significantly improved the detection of HIV infection among FSWs from low-grade venues in Guangxi. Our findings also provided the useful baseline data of HIV incidence among this population for targeting local HIV prevention, intervention, monitoring and treatment.Jianjun LiHongman ZhangZhiyong ShenYuejiao ZhouNingye FangLu WangBin WangJiangwei WangZhenzhu TangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99522 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianjun Li Hongman Zhang Zhiyong Shen Yuejiao Zhou Ningye Fang Lu Wang Bin Wang Jiangwei Wang Zhenzhu Tang Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.
description	<h4>Background</h4>Guangxi has become one of the provinces with the most severe HIV-1 epidemic in China, where heterosexual contact is the dominant transmission route. However, data of acute HIV infections and HIV incidence among female sex workers (FSWs) from low-grade venues are scant.<h4>Methods</h4>A cross-sectional survey was performed among FSWs from low-grade venues in Guangxi. HIV antibody screening was performed by rapid testing (RT). HIV antibody-negative specimens were screened by pooled nucleic acid amplification testing (NAAT) for acute HIV infections. HIV antibody-positive specimens were further analyzed by Western blot (WB), followed by an HIV-1 BED capture enzyme immunoassay (BED-CEIA) to identify the recent infections. HIV-1 incidence was estimated by the data of pooled NAAT and BED-CEIA, respectively.<h4>Results</h4>A total of 7936 FSWs were recruited and answered the questionnaires. We successfully collected the blood samples from 6469 (81.5%) participants, of which 139 (2.1%) were HIV antibody-positive and 6330 (97.9%) were HIV antibody-negative by RT. With pooled NAAT, 7 cases were found to be HIV RNA positive, representing an additional 5.0% of HIV-infected persons and an estimated HIV incidence of 1.45 (95% CI: 1.17-1.76) per 100 person years. There were 137 positive and 2 indeterminate by WB, of which 124 (90.5%) positive specimens were subjected to BED-CEIA testing identifying 28 recent infections. The HIV incidence determined by BED-CEIA testing was 1.04 (95% CI: 0.65-1.43) per 100 person years. The overall prevalence of HIV among FSWs from low-grade venues in Guangxi was 2.2% (95% CI: 1.9-2.6).<h4>Conclusions</h4>We found that the addition of HIV RNA screening to routine HIV antibody testing significantly improved the detection of HIV infection among FSWs from low-grade venues in Guangxi. Our findings also provided the useful baseline data of HIV incidence among this population for targeting local HIV prevention, intervention, monitoring and treatment.
format	article
author	Jianjun Li Hongman Zhang Zhiyong Shen Yuejiao Zhou Ningye Fang Lu Wang Bin Wang Jiangwei Wang Zhenzhu Tang
author_facet	Jianjun Li Hongman Zhang Zhiyong Shen Yuejiao Zhou Ningye Fang Lu Wang Bin Wang Jiangwei Wang Zhenzhu Tang
author_sort	Jianjun Li
title	Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.
title_short	Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.
title_full	Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.
title_fullStr	Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.
title_full_unstemmed	Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.
title_sort	screening for acute hiv infections and estimating hiv incidence among female sex workers from low-grade venues in guangxi, china.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/597694a3d5364a63a0e5ca51039e6279
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Screening for acute HIV infections and estimating HIV incidence among female sex workers from low-grade venues in Guangxi, China.

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