TBCK influences cell proliferation, cell size and mTOR signaling pathway.

Mammalian target of rapamycin (mTOR) is a central regulator for both cell proliferation and cell growth; however, little is known about the regulation of mTOR expression at the transcriptional level. Here, we provide evidences that a conserved human protein TBCK (TBC1 domain containing kinase) is in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yueli Liu, Xiaoyi Yan, Tianhua Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/597907ba5c4d4ab4acdaf1d605372fcb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:597907ba5c4d4ab4acdaf1d605372fcb
record_format	dspace
spelling	oai:doaj.org-article:597907ba5c4d4ab4acdaf1d605372fcb2021-11-18T08:59:10ZTBCK influences cell proliferation, cell size and mTOR signaling pathway.1932-620310.1371/journal.pone.0071349https://doaj.org/article/597907ba5c4d4ab4acdaf1d605372fcb2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977024/?tool=EBIhttps://doaj.org/toc/1932-6203Mammalian target of rapamycin (mTOR) is a central regulator for both cell proliferation and cell growth; however, little is known about the regulation of mTOR expression at the transcriptional level. Here, we provide evidences that a conserved human protein TBCK (TBC1 domain containing kinase) is involved in the regulation of mTOR signaling pathway. Depletion of TBCK significantly inhibits cell proliferation, reduces cell size, and disrupts the organization of actin, but not microtubule. Knockdown of TBCK induces a significant decrease in the protein levels of components of mTOR complex (mTORC), and suppresses the activity of mTOR signaling, but not MAPK or PDK1/Akt pathway. Further results show that TBCK influences the expression of mTORC components at the transcriptional level. Thus, these data suggest that TBCK may play an important role in cell proliferation, cell growth and actin organization possibly by modulating mTOR pathway.Yueli LiuXiaoyi YanTianhua ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71349 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yueli Liu Xiaoyi Yan Tianhua Zhou TBCK influences cell proliferation, cell size and mTOR signaling pathway.
description	Mammalian target of rapamycin (mTOR) is a central regulator for both cell proliferation and cell growth; however, little is known about the regulation of mTOR expression at the transcriptional level. Here, we provide evidences that a conserved human protein TBCK (TBC1 domain containing kinase) is involved in the regulation of mTOR signaling pathway. Depletion of TBCK significantly inhibits cell proliferation, reduces cell size, and disrupts the organization of actin, but not microtubule. Knockdown of TBCK induces a significant decrease in the protein levels of components of mTOR complex (mTORC), and suppresses the activity of mTOR signaling, but not MAPK or PDK1/Akt pathway. Further results show that TBCK influences the expression of mTORC components at the transcriptional level. Thus, these data suggest that TBCK may play an important role in cell proliferation, cell growth and actin organization possibly by modulating mTOR pathway.
format	article
author	Yueli Liu Xiaoyi Yan Tianhua Zhou
author_facet	Yueli Liu Xiaoyi Yan Tianhua Zhou
author_sort	Yueli Liu
title	TBCK influences cell proliferation, cell size and mTOR signaling pathway.
title_short	TBCK influences cell proliferation, cell size and mTOR signaling pathway.
title_full	TBCK influences cell proliferation, cell size and mTOR signaling pathway.
title_fullStr	TBCK influences cell proliferation, cell size and mTOR signaling pathway.
title_full_unstemmed	TBCK influences cell proliferation, cell size and mTOR signaling pathway.
title_sort	tbck influences cell proliferation, cell size and mtor signaling pathway.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/597907ba5c4d4ab4acdaf1d605372fcb
work_keys_str_mv	AT yueliliu tbckinfluencescellproliferationcellsizeandmtorsignalingpathway AT xiaoyiyan tbckinfluencescellproliferationcellsizeandmtorsignalingpathway AT tianhuazhou tbckinfluencescellproliferationcellsizeandmtorsignalingpathway
_version_	1718421082780729344

TBCK influences cell proliferation, cell size and mTOR signaling pathway.

Ejemplares similares