Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass

Background. Aerobic exercise has been proven to have a positive effect on cardiac function after hypertension; however, the mechanism is not entirely clarified. Skeletal muscle mass and microcirculation are closely associated with blood pressure and cardiac function. Objective. This study was design...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ling-Yan Yuan, Pei-Zhao Du, Min-Min Wei, Qi Zhang, Le Lu, Xu Tian, Shao-ting Fu, Xiao-Li Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/597c377079f849fca83a9c2e167efa33
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:597c377079f849fca83a9c2e167efa33
record_format	dspace
spelling	oai:doaj.org-article:597c377079f849fca83a9c2e167efa332021-11-29T00:56:11ZAerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass1741-428810.1155/2021/8279369https://doaj.org/article/597c377079f849fca83a9c2e167efa332021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8279369https://doaj.org/toc/1741-4288Background. Aerobic exercise has been proven to have a positive effect on cardiac function after hypertension; however, the mechanism is not entirely clarified. Skeletal muscle mass and microcirculation are closely associated with blood pressure and cardiac function. Objective. This study was designed to investigate the effects of aerobic exercise on the skeletal muscle capillary and muscle mass, to explore the possible mechanisms involved in exercise-induced mitigation of cardiac dysfunction in pressure overload mice. Methods. In this study, 60 BALB/C mice aged 8 weeks were randomly divided into 3 groups: control (CON), TAC, and TAC plus exercise (TAE) group and utilized transverse aortic constriction (TAC) to establish hypertensive model; meanwhile, treadmill training is used for aerobic exercise. After 5 days of recovery, mice in the TAE group were subjected to 10-week aerobic exercise. Carotid pressure and cardiac function were examined before mice were executed by Millar catheter and ultrasound, respectively. Muscle mass of gastrocnemius was weighed; cross-sectional area and the number of capillaries of gastrocnemius were detected by HE and immunohistochemistry, respectively. The mRNA and protein levels of VEGF in skeletal muscle were determined by RT-PCR and western blot, respectively. Results. We found that ① 10-week aerobic exercise counteracted hypertension and attenuated cardiac dysfunction in TAC-induced hypertensive mice; ② TAC decreased muscle mass of gastrocnemius and resulted in muscle atrophy, while 10-week aerobic exercise could reserve transverse aortic constriction-induced the decline of muscle mass and muscle atrophy; and ③ TAC reduced the number of capillaries and the protein level of VEGF in gastrocnemius, whereas 10-week aerobic exercise augmented the number of capillaries, the mRNA and protein levels of VEGF in mice were subjected to TAC surgery. Conclusions. This study indicates that 10-week aerobic exercise might fulfill its blood pressure-lowering effect via improving skeletal muscle microcirculation and increasing muscle mass.Ling-Yan YuanPei-Zhao DuMin-Min WeiQi ZhangLe LuXu TianShao-ting FuXiao-Li ZengHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Ling-Yan Yuan Pei-Zhao Du Min-Min Wei Qi Zhang Le Lu Xu Tian Shao-ting Fu Xiao-Li Zeng Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass
description	Background. Aerobic exercise has been proven to have a positive effect on cardiac function after hypertension; however, the mechanism is not entirely clarified. Skeletal muscle mass and microcirculation are closely associated with blood pressure and cardiac function. Objective. This study was designed to investigate the effects of aerobic exercise on the skeletal muscle capillary and muscle mass, to explore the possible mechanisms involved in exercise-induced mitigation of cardiac dysfunction in pressure overload mice. Methods. In this study, 60 BALB/C mice aged 8 weeks were randomly divided into 3 groups: control (CON), TAC, and TAC plus exercise (TAE) group and utilized transverse aortic constriction (TAC) to establish hypertensive model; meanwhile, treadmill training is used for aerobic exercise. After 5 days of recovery, mice in the TAE group were subjected to 10-week aerobic exercise. Carotid pressure and cardiac function were examined before mice were executed by Millar catheter and ultrasound, respectively. Muscle mass of gastrocnemius was weighed; cross-sectional area and the number of capillaries of gastrocnemius were detected by HE and immunohistochemistry, respectively. The mRNA and protein levels of VEGF in skeletal muscle were determined by RT-PCR and western blot, respectively. Results. We found that ① 10-week aerobic exercise counteracted hypertension and attenuated cardiac dysfunction in TAC-induced hypertensive mice; ② TAC decreased muscle mass of gastrocnemius and resulted in muscle atrophy, while 10-week aerobic exercise could reserve transverse aortic constriction-induced the decline of muscle mass and muscle atrophy; and ③ TAC reduced the number of capillaries and the protein level of VEGF in gastrocnemius, whereas 10-week aerobic exercise augmented the number of capillaries, the mRNA and protein levels of VEGF in mice were subjected to TAC surgery. Conclusions. This study indicates that 10-week aerobic exercise might fulfill its blood pressure-lowering effect via improving skeletal muscle microcirculation and increasing muscle mass.
format	article
author	Ling-Yan Yuan Pei-Zhao Du Min-Min Wei Qi Zhang Le Lu Xu Tian Shao-ting Fu Xiao-Li Zeng
author_facet	Ling-Yan Yuan Pei-Zhao Du Min-Min Wei Qi Zhang Le Lu Xu Tian Shao-ting Fu Xiao-Li Zeng
author_sort	Ling-Yan Yuan
title	Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass
title_short	Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass
title_full	Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass
title_fullStr	Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass
title_full_unstemmed	Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass
title_sort	aerobic exercise attenuates pressure overload-induced cardiac dysfunction through promoting skeletal muscle microcirculation and increasing muscle mass
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/597c377079f849fca83a9c2e167efa33
work_keys_str_mv	AT lingyanyuan aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT peizhaodu aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT minminwei aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT qizhang aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT lelu aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT xutian aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT shaotingfu aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass AT xiaolizeng aerobicexerciseattenuatespressureoverloadinducedcardiacdysfunctionthroughpromotingskeletalmusclemicrocirculationandincreasingmusclemass
_version_	1718407708270395392

Aerobic Exercise Attenuates Pressure Overload-Induced Cardiac Dysfunction through Promoting Skeletal Muscle Microcirculation and Increasing Muscle Mass

Ejemplares similares