Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.

Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory T cells. Recent mouse experiments have shown...

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Autores principales:	Kang-Ling Liao, Xue-Feng Bai, Avner Friedman
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/597def367479463eb03027fe3f355b15
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spelling	oai:doaj.org-article:597def367479463eb03027fe3f355b152021-11-25T05:55:02ZMathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.1932-620310.1371/journal.pone.0110126https://doaj.org/article/597def367479463eb03027fe3f355b152014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110126https://doaj.org/toc/1932-6203Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory T cells. Recent mouse experiments have shown that IL-35 produced by cancer cells promotes tumor growth via enhancing myeloid cell accumulation and angiogenesis, and reducing the infiltration of activated CD8[Formula: see text] T cells into tumor microenvironment. In the present paper we develop a mathematical model based on these experimental results. We include in the model an anti-IL-35 drug as treatment. The extended model (with drug) is used to design protocols of anti-IL-35 injections for treatment of cancer. We find that with a fixed total amount of drug, continuous injection has better efficacy than intermittent injections in reducing the tumor load while the treatment is ongoing. We also find that the percentage of tumor reduction under anti-IL-35 treatment improves when the production of IL-35 by cancer is increased.Kang-Ling LiaoXue-Feng BaiAvner FriedmanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110126 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kang-Ling Liao Xue-Feng Bai Avner Friedman Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.
description	Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory T cells. Recent mouse experiments have shown that IL-35 produced by cancer cells promotes tumor growth via enhancing myeloid cell accumulation and angiogenesis, and reducing the infiltration of activated CD8[Formula: see text] T cells into tumor microenvironment. In the present paper we develop a mathematical model based on these experimental results. We include in the model an anti-IL-35 drug as treatment. The extended model (with drug) is used to design protocols of anti-IL-35 injections for treatment of cancer. We find that with a fixed total amount of drug, continuous injection has better efficacy than intermittent injections in reducing the tumor load while the treatment is ongoing. We also find that the percentage of tumor reduction under anti-IL-35 treatment improves when the production of IL-35 by cancer is increased.
format	article
author	Kang-Ling Liao Xue-Feng Bai Avner Friedman
author_facet	Kang-Ling Liao Xue-Feng Bai Avner Friedman
author_sort	Kang-Ling Liao
title	Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.
title_short	Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.
title_full	Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.
title_fullStr	Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.
title_full_unstemmed	Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.
title_sort	mathematical modeling of interleukin-35 promoting tumor growth and angiogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/597def367479463eb03027fe3f355b15
work_keys_str_mv	AT kanglingliao mathematicalmodelingofinterleukin35promotingtumorgrowthandangiogenesis AT xuefengbai mathematicalmodelingofinterleukin35promotingtumorgrowthandangiogenesis AT avnerfriedman mathematicalmodelingofinterleukin35promotingtumorgrowthandangiogenesis
_version_	1718414401628798976

Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.

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