The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold in promoting UPF1 phosphorylation by SMG1 to...

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Autores principales:	Roberto Melero, Nele Hug, Andrés López-Perrote, Akio Yamashita, Javier F. Cáceres, Oscar Llorca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/597e0086359044b69a338a8768143197
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spelling	oai:doaj.org-article:597e0086359044b69a338a87681431972021-12-02T15:35:43ZThe RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation10.1038/ncomms105852041-1723https://doaj.org/article/597e0086359044b69a338a87681431972016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10585https://doaj.org/toc/2041-1723UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold in promoting UPF1 phosphorylation by SMG1 to promotes NMD.Roberto MeleroNele HugAndrés López-PerroteAkio YamashitaJavier F. CáceresOscar LlorcaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Roberto Melero Nele Hug Andrés López-Perrote Akio Yamashita Javier F. Cáceres Oscar Llorca The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
description	UPF1 is a central Nonsense-mediated mRNA decay—(NMD), a mechanism to degrade mRNAs containing premature translation termination codons-factor—whose phosphorylation is key to triggering NMD. Here the authors show that the DHX34 helicase acts as a scaffold in promoting UPF1 phosphorylation by SMG1 to promotes NMD.
format	article
author	Roberto Melero Nele Hug Andrés López-Perrote Akio Yamashita Javier F. Cáceres Oscar Llorca
author_facet	Roberto Melero Nele Hug Andrés López-Perrote Akio Yamashita Javier F. Cáceres Oscar Llorca
author_sort	Roberto Melero
title	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
title_short	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
title_full	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
title_fullStr	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
title_full_unstemmed	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
title_sort	rna helicase dhx34 functions as a scaffold for smg1-mediated upf1 phosphorylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/597e0086359044b69a338a8768143197
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The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

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