A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer

Ping Zhang,1,2 Wenhui Yi,1,2 Jin Hou,3 Sweejiang Yoo,1,2 Weiqiu Jin,1,2 Qisheng Yang1,2 1Key Laboratory for Physical Electronics and Devices of the Ministry of Education, School of Information and Electronics Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People&rsq...

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Autores principales:	Zhang P, Yi W, Hou J, Yoo S, Jin W, Yang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	drug-containing nanocomposites characterization near-infrared radiation cancer therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5988cf1af781422dbc82986a81f531da
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spelling	oai:doaj.org-article:5988cf1af781422dbc82986a81f531da2021-12-02T03:51:24ZA carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer1178-2013https://doaj.org/article/5988cf1af781422dbc82986a81f531da2018-05-01T00:00:00Zhttps://www.dovepress.com/a-carbon-nanotube-gemcitabine-lentinan-three-component-composite-for-c-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ping Zhang,1,2 Wenhui Yi,1,2 Jin Hou,3 Sweejiang Yoo,1,2 Weiqiu Jin,1,2 Qisheng Yang1,2 1Key Laboratory for Physical Electronics and Devices of the Ministry of Education, School of Information and Electronics Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Key Laboratory for Information Photonic Technology of Shaanxi Province, School of Information and Electronics Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Pharmacology, School of Basic Medical Sciences, Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China Purpose: Gemcitabine’s clinical application is limited due to its short plasma half-life and poor uptake by cells. To address this problem, a drug delivery three-component composite, multiwalled carbon nanotubes (MWNTs)/gemcitabine (Ge)/lentinan (Le; MWNTs-Ge-Le), was fabricated in our study. Moreover, the combination of chemotherapy and photothermal therapy was employed to enhance antitumor efficacy. Methods: In this study, we conjugated gemcitabine and lentinan with MWNTs via a covalent and noncovalent way to functionalize with MWNTs, and the chemical structure of MWNTs-Ge-Le was characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis and transmission electron microscopy. Using the composite and an 808 nm laser, we treated tumors, both in vitro and in vivo, and investigated the photothermal responses and the anticancer efficacy. Results: The MWNTs-Ge-Le composite could efficiently cross cell membrane, having a higher antitumor activity than MWNTs, gemcitabine and MWNTs-Ge in vitro and in vivo. Our study on the MWNTs-Ge-Le composite with an 808 nm laser radiation showed the combination of drug therapy and near-infrared photothermal therapy possesses great synergistic antitumor efficacy. Conclusion: The MWNTs-Ge-Le three-component anticancer composite can serve as a promising candidate for cancer therapy in the combination of chemotherapy and photothermal therapy. Keywords: drug-containing nanocomposites, characterization, near-infrared radiation, cancer therapyZhang PYi WHou JYoo SJin WYang QDove Medical Pressarticledrug-containing nanocompositescharacterizationnear-infrared radiationcancer therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3069-3080 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug-containing nanocomposites characterization near-infrared radiation cancer therapy Medicine (General) R5-920
spellingShingle	drug-containing nanocomposites characterization near-infrared radiation cancer therapy Medicine (General) R5-920 Zhang P Yi W Hou J Yoo S Jin W Yang Q A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
description	Ping Zhang,1,2 Wenhui Yi,1,2 Jin Hou,3 Sweejiang Yoo,1,2 Weiqiu Jin,1,2 Qisheng Yang1,2 1Key Laboratory for Physical Electronics and Devices of the Ministry of Education, School of Information and Electronics Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Key Laboratory for Information Photonic Technology of Shaanxi Province, School of Information and Electronics Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Pharmacology, School of Basic Medical Sciences, Xi’an Medical University, Xi’an, Shaanxi, People’s Republic of China Purpose: Gemcitabine’s clinical application is limited due to its short plasma half-life and poor uptake by cells. To address this problem, a drug delivery three-component composite, multiwalled carbon nanotubes (MWNTs)/gemcitabine (Ge)/lentinan (Le; MWNTs-Ge-Le), was fabricated in our study. Moreover, the combination of chemotherapy and photothermal therapy was employed to enhance antitumor efficacy. Methods: In this study, we conjugated gemcitabine and lentinan with MWNTs via a covalent and noncovalent way to functionalize with MWNTs, and the chemical structure of MWNTs-Ge-Le was characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, thermogravimetric analysis and transmission electron microscopy. Using the composite and an 808 nm laser, we treated tumors, both in vitro and in vivo, and investigated the photothermal responses and the anticancer efficacy. Results: The MWNTs-Ge-Le composite could efficiently cross cell membrane, having a higher antitumor activity than MWNTs, gemcitabine and MWNTs-Ge in vitro and in vivo. Our study on the MWNTs-Ge-Le composite with an 808 nm laser radiation showed the combination of drug therapy and near-infrared photothermal therapy possesses great synergistic antitumor efficacy. Conclusion: The MWNTs-Ge-Le three-component anticancer composite can serve as a promising candidate for cancer therapy in the combination of chemotherapy and photothermal therapy. Keywords: drug-containing nanocomposites, characterization, near-infrared radiation, cancer therapy
format	article
author	Zhang P Yi W Hou J Yoo S Jin W Yang Q
author_facet	Zhang P Yi W Hou J Yoo S Jin W Yang Q
author_sort	Zhang P
title	A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
title_short	A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
title_full	A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
title_fullStr	A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
title_full_unstemmed	A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
title_sort	carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5988cf1af781422dbc82986a81f531da
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A carbon nanotube-gemcitabine-lentinan three-component composite for chemo-photothermal synergistic therapy of cancer

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