Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.

<h4>Background/aim</h4>Patients with attention-deficit hyperactivity disorder (ADHD) manifest symptoms of hyperactivity, impulsivity, and/or inattention. ADHD medications available in Japan are limited compared with those in Western countries. Prescribing status has not been sufficiently...

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Autores principales:	Yoshinori Sasaki, Noa Tsujii, Shouko Sasaki, Hikaru Sunakawa, Yusuke Toguchi, Syuuichi Tanase, Kiyoshi Saito, Rena Shinohara, Toshinari Kurokouchi, Kaori Sugimoto, Kotoe Itagaki, Yukino Yoshida, Saori Namekata, Momoka Takahashi, Ikuhiro Harada, Yuuki Hakosima, Kumi Inazaki, Yuta Yoshimura, Yuki Mizumoto, Takayuki Okada, Masahide Usami
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5988f51d49174cf0b96a9e5dc3af6cf6
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spelling	oai:doaj.org-article:5988f51d49174cf0b96a9e5dc3af6cf62021-12-02T20:11:07ZCurrent use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.1932-620310.1371/journal.pone.0252420https://doaj.org/article/5988f51d49174cf0b96a9e5dc3af6cf62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252420https://doaj.org/toc/1932-6203<h4>Background/aim</h4>Patients with attention-deficit hyperactivity disorder (ADHD) manifest symptoms of hyperactivity, impulsivity, and/or inattention. ADHD medications available in Japan are limited compared with those in Western countries. Prescribing status has not been sufficiently evaluated in clinical settings in Japan. This study investigated the current use of ADHD medications and characteristics of patients who received multiple ADHD medications in a clinical setting in Japan.<h4>Methods</h4>Study participants were those who visited the Department of Child and Adolescent Psychiatry, Kohnodai Hospital between April 2015 and March 2020. We investigated patients who received osmotic-controlled release oral delivery system methylphenidate, atomoxetine, or guanfacine. A retrospective case-control design was used to evaluate the characteristics of patients who received multiple ADHD medications. Patients who were given three ADHD medications were defined as the case group. Randomly sampled sex- and age-matched patients diagnosed with ADHD were defined as the control group. We compared data for child-to-parent violence, antisocial behavior, suicide attempt or self-harm, abuse history, refusal to attend school, and two psychological rating scales (the ADHD-Rating Scale and Tokyo Autistic Behavior Scale).<h4>Results</h4>Among the 878 patients who were prescribed any ADHD medications, 43 (4.9%) received three ADHD medications. Logistic regression revealed that children with severe ADHD symptoms, autistic characteristics, or tendency of child-to-parent violence were more likely to have been prescribed three medications during their treatment.<h4>Conclusions</h4>Our findings suggest the approach to prevent the use of multiple ADHD medications. A prospective study to investigate the causality between prescribing status and clinical characteristics is warranted.Yoshinori SasakiNoa TsujiiShouko SasakiHikaru SunakawaYusuke ToguchiSyuuichi TanaseKiyoshi SaitoRena ShinoharaToshinari KurokouchiKaori SugimotoKotoe ItagakiYukino YoshidaSaori NamekataMomoka TakahashiIkuhiro HaradaYuuki HakosimaKumi InazakiYuta YoshimuraYuki MizumotoTakayuki OkadaMasahide UsamiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252420 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshinori Sasaki Noa Tsujii Shouko Sasaki Hikaru Sunakawa Yusuke Toguchi Syuuichi Tanase Kiyoshi Saito Rena Shinohara Toshinari Kurokouchi Kaori Sugimoto Kotoe Itagaki Yukino Yoshida Saori Namekata Momoka Takahashi Ikuhiro Harada Yuuki Hakosima Kumi Inazaki Yuta Yoshimura Yuki Mizumoto Takayuki Okada Masahide Usami Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.
description	<h4>Background/aim</h4>Patients with attention-deficit hyperactivity disorder (ADHD) manifest symptoms of hyperactivity, impulsivity, and/or inattention. ADHD medications available in Japan are limited compared with those in Western countries. Prescribing status has not been sufficiently evaluated in clinical settings in Japan. This study investigated the current use of ADHD medications and characteristics of patients who received multiple ADHD medications in a clinical setting in Japan.<h4>Methods</h4>Study participants were those who visited the Department of Child and Adolescent Psychiatry, Kohnodai Hospital between April 2015 and March 2020. We investigated patients who received osmotic-controlled release oral delivery system methylphenidate, atomoxetine, or guanfacine. A retrospective case-control design was used to evaluate the characteristics of patients who received multiple ADHD medications. Patients who were given three ADHD medications were defined as the case group. Randomly sampled sex- and age-matched patients diagnosed with ADHD were defined as the control group. We compared data for child-to-parent violence, antisocial behavior, suicide attempt or self-harm, abuse history, refusal to attend school, and two psychological rating scales (the ADHD-Rating Scale and Tokyo Autistic Behavior Scale).<h4>Results</h4>Among the 878 patients who were prescribed any ADHD medications, 43 (4.9%) received three ADHD medications. Logistic regression revealed that children with severe ADHD symptoms, autistic characteristics, or tendency of child-to-parent violence were more likely to have been prescribed three medications during their treatment.<h4>Conclusions</h4>Our findings suggest the approach to prevent the use of multiple ADHD medications. A prospective study to investigate the causality between prescribing status and clinical characteristics is warranted.
format	article
author	Yoshinori Sasaki Noa Tsujii Shouko Sasaki Hikaru Sunakawa Yusuke Toguchi Syuuichi Tanase Kiyoshi Saito Rena Shinohara Toshinari Kurokouchi Kaori Sugimoto Kotoe Itagaki Yukino Yoshida Saori Namekata Momoka Takahashi Ikuhiro Harada Yuuki Hakosima Kumi Inazaki Yuta Yoshimura Yuki Mizumoto Takayuki Okada Masahide Usami
author_facet	Yoshinori Sasaki Noa Tsujii Shouko Sasaki Hikaru Sunakawa Yusuke Toguchi Syuuichi Tanase Kiyoshi Saito Rena Shinohara Toshinari Kurokouchi Kaori Sugimoto Kotoe Itagaki Yukino Yoshida Saori Namekata Momoka Takahashi Ikuhiro Harada Yuuki Hakosima Kumi Inazaki Yuta Yoshimura Yuki Mizumoto Takayuki Okada Masahide Usami
author_sort	Yoshinori Sasaki
title	Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.
title_short	Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.
title_full	Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.
title_fullStr	Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.
title_full_unstemmed	Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.
title_sort	current use of attention-deficit hyperactivity disorder (adhd) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple adhd medications in japan.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5988f51d49174cf0b96a9e5dc3af6cf6
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Current use of attention-deficit hyperactivity disorder (ADHD) medications and clinical characteristics of child and adolescent psychiatric outpatients prescribed multiple ADHD medications in Japan.

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