Electrophysiological assessment of temporal envelope processing in cochlear implant users

Abstract Cochlear-implant (CI) users rely on temporal envelope modulations (TEMs) to understand speech, and clinical outcomes depend on the accuracy with which these TEMs are encoded by the electrically-stimulated neural ensembles. Non-invasive EEG measures of this encoding could help clinicians ide...

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Autores principales:	Robin Gransier, Robert P. Carlyon, Jan Wouters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5990ff4d93ab44a88fe444e4fdb49b8e
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spelling	oai:doaj.org-article:5990ff4d93ab44a88fe444e4fdb49b8e2021-12-02T18:48:01ZElectrophysiological assessment of temporal envelope processing in cochlear implant users10.1038/s41598-020-72235-92045-2322https://doaj.org/article/5990ff4d93ab44a88fe444e4fdb49b8e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72235-9https://doaj.org/toc/2045-2322Abstract Cochlear-implant (CI) users rely on temporal envelope modulations (TEMs) to understand speech, and clinical outcomes depend on the accuracy with which these TEMs are encoded by the electrically-stimulated neural ensembles. Non-invasive EEG measures of this encoding could help clinicians identify and disable electrodes that evoke poor neural responses so as to improve CI outcomes. However, recording EEG during CI stimulation reveals huge stimulation artifacts that are up to orders of magnitude larger than the neural response. Here we used a custom-built EEG system having an exceptionally high sample rate to accurately measure the artefact, which we then removed using linear interpolation so as to reveal the neural response during continuous electrical stimulation. In ten adult CI users, we measured the 40-Hz electrically evoked auditory steady-state response (eASSR) and electrically evoked auditory change complex (eACC) to amplitude-modulated 900-pulses-per-second pulse trains, stimulated in monopolar mode (i.e. the clinical default), and at different modulation depths. We successfully measured artifact-free 40-Hz eASSRs and eACCs. Moreover, we found that the 40-Hz eASSR, in contrast to the eACC, showed substantial responses even at shallow modulation depths. We argue that the 40-Hz eASSR is a clinically feasible objective measure to assess TEM encoding in CI users.Robin GransierRobert P. CarlyonJan WoutersNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robin Gransier Robert P. Carlyon Jan Wouters Electrophysiological assessment of temporal envelope processing in cochlear implant users
description	Abstract Cochlear-implant (CI) users rely on temporal envelope modulations (TEMs) to understand speech, and clinical outcomes depend on the accuracy with which these TEMs are encoded by the electrically-stimulated neural ensembles. Non-invasive EEG measures of this encoding could help clinicians identify and disable electrodes that evoke poor neural responses so as to improve CI outcomes. However, recording EEG during CI stimulation reveals huge stimulation artifacts that are up to orders of magnitude larger than the neural response. Here we used a custom-built EEG system having an exceptionally high sample rate to accurately measure the artefact, which we then removed using linear interpolation so as to reveal the neural response during continuous electrical stimulation. In ten adult CI users, we measured the 40-Hz electrically evoked auditory steady-state response (eASSR) and electrically evoked auditory change complex (eACC) to amplitude-modulated 900-pulses-per-second pulse trains, stimulated in monopolar mode (i.e. the clinical default), and at different modulation depths. We successfully measured artifact-free 40-Hz eASSRs and eACCs. Moreover, we found that the 40-Hz eASSR, in contrast to the eACC, showed substantial responses even at shallow modulation depths. We argue that the 40-Hz eASSR is a clinically feasible objective measure to assess TEM encoding in CI users.
format	article
author	Robin Gransier Robert P. Carlyon Jan Wouters
author_facet	Robin Gransier Robert P. Carlyon Jan Wouters
author_sort	Robin Gransier
title	Electrophysiological assessment of temporal envelope processing in cochlear implant users
title_short	Electrophysiological assessment of temporal envelope processing in cochlear implant users
title_full	Electrophysiological assessment of temporal envelope processing in cochlear implant users
title_fullStr	Electrophysiological assessment of temporal envelope processing in cochlear implant users
title_full_unstemmed	Electrophysiological assessment of temporal envelope processing in cochlear implant users
title_sort	electrophysiological assessment of temporal envelope processing in cochlear implant users
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5990ff4d93ab44a88fe444e4fdb49b8e
work_keys_str_mv	AT robingransier electrophysiologicalassessmentoftemporalenvelopeprocessingincochlearimplantusers AT robertpcarlyon electrophysiologicalassessmentoftemporalenvelopeprocessingincochlearimplantusers AT janwouters electrophysiologicalassessmentoftemporalenvelopeprocessingincochlearimplantusers
_version_	1718377623989518336

Electrophysiological assessment of temporal envelope processing in cochlear implant users

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