Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial

Ursolic acid (UA) is a natural compound that shows anti-inflammatory actions. However, no human studies have investigated the cytokine profile during the RT and UA consumption. The purpose of this study was to verify if UA is able to potentiate the anti-inflammatory activity after RT, reflecting in...

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Autores principales:	Patrícia Cristina Barreto Lobo, Gustavo Duarte Pimentel
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Inflammation Cytokines Ursolic acid Resistance training Young adult Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/599310e569ef4063b9b3b4e6eb1f61d3
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spelling	oai:doaj.org-article:599310e569ef4063b9b3b4e6eb1f61d32021-12-02T04:59:05ZUrsolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial0753-332210.1016/j.biopha.2021.112289https://doaj.org/article/599310e569ef4063b9b3b4e6eb1f61d32022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010738https://doaj.org/toc/0753-3322Ursolic acid (UA) is a natural compound that shows anti-inflammatory actions. However, no human studies have investigated the cytokine profile during the RT and UA consumption. The purpose of this study was to verify if UA is able to potentiate the anti-inflammatory activity after RT, reflecting in the reduction of blood inflammatory markers in healthy men. Twenty-seven participants were allocated to two groups: control (CON) (n = 13) and UA (n = 14). For 8weeks, each group performed RT and consumed capsules containing a placebo (400 mg/day) or UA (400 mg/day). Serum cytokine concentrations were evaluated before and after the training period. There was no difference in the serum cytokine concentrations of TNF-α, IL-10 and IL-6 (p > 0.05). In conclusion, UA supplementation for 8weeks was not able to change the blood TNF-α, IL-10, and IL-6 concentrations in healthy men undergoing RT. However, further studies are warranted to investigate other inflammatory markers.Patrícia Cristina Barreto LoboGustavo Duarte PimentelElsevierarticleInflammationCytokinesUrsolic acidResistance trainingYoung adultTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112289- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inflammation Cytokines Ursolic acid Resistance training Young adult Therapeutics. Pharmacology RM1-950
spellingShingle	Inflammation Cytokines Ursolic acid Resistance training Young adult Therapeutics. Pharmacology RM1-950 Patrícia Cristina Barreto Lobo Gustavo Duarte Pimentel Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial
description	Ursolic acid (UA) is a natural compound that shows anti-inflammatory actions. However, no human studies have investigated the cytokine profile during the RT and UA consumption. The purpose of this study was to verify if UA is able to potentiate the anti-inflammatory activity after RT, reflecting in the reduction of blood inflammatory markers in healthy men. Twenty-seven participants were allocated to two groups: control (CON) (n = 13) and UA (n = 14). For 8weeks, each group performed RT and consumed capsules containing a placebo (400 mg/day) or UA (400 mg/day). Serum cytokine concentrations were evaluated before and after the training period. There was no difference in the serum cytokine concentrations of TNF-α, IL-10 and IL-6 (p > 0.05). In conclusion, UA supplementation for 8weeks was not able to change the blood TNF-α, IL-10, and IL-6 concentrations in healthy men undergoing RT. However, further studies are warranted to investigate other inflammatory markers.
format	article
author	Patrícia Cristina Barreto Lobo Gustavo Duarte Pimentel
author_facet	Patrícia Cristina Barreto Lobo Gustavo Duarte Pimentel
author_sort	Patrícia Cristina Barreto Lobo
title	Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial
title_short	Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial
title_full	Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial
title_fullStr	Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial
title_full_unstemmed	Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial
title_sort	ursolic acid does not change the cytokine levels following resistance training in healthy men: a pilot balanced, double-blind and placebo-controlled clinical trial
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/599310e569ef4063b9b3b4e6eb1f61d3
work_keys_str_mv	AT patriciacristinabarretolobo ursolicaciddoesnotchangethecytokinelevelsfollowingresistancetraininginhealthymenapilotbalanceddoubleblindandplacebocontrolledclinicaltrial AT gustavoduartepimentel ursolicaciddoesnotchangethecytokinelevelsfollowingresistancetraininginhealthymenapilotbalanceddoubleblindandplacebocontrolledclinicaltrial
_version_	1718400889791709184

Ursolic acid does not change the cytokine levels following resistance training in healthy men: A pilot balanced, double-blind and placebo-controlled clinical trial

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