Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation

Abstract SARS-CoV-2, the virus that causes COVID-19, is still a widespread threat to society. The spike protein of this virus facilitates viral entry into the host cell. Here, the denaturation of the S1 subunit of this spike protein by 2.45 GHz electromagnetic radiation was studied quantitatively. T...

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Autores principales:	Pooya Afaghi, Michael Anthony Lapolla, Khashayar Ghandi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59951e7f8fa84bda84d5838c78f56ed6
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spelling	oai:doaj.org-article:59951e7f8fa84bda84d5838c78f56ed62021-12-05T12:13:53ZDenaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation10.1038/s41598-021-02753-72045-2322https://doaj.org/article/59951e7f8fa84bda84d5838c78f56ed62021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02753-7https://doaj.org/toc/2045-2322Abstract SARS-CoV-2, the virus that causes COVID-19, is still a widespread threat to society. The spike protein of this virus facilitates viral entry into the host cell. Here, the denaturation of the S1 subunit of this spike protein by 2.45 GHz electromagnetic radiation was studied quantitatively. The study only pertains to the pure electromagnetic effects by eliminating the bulk heating effect of the microwave radiation in an innovative setup that is capable of controlling the temperature of the sample at any desired intensity of the electromagnetic field. This study was performed at the internal human body temperature, 37 °C, for a relatively short amount of time under a high-power electromagnetic field. The results showed that irradiating the protein with a 700 W, 2.45 GHz electromagnetic field for 2 min can denature the protein to around 95%. In comparison, this is comparable to thermal denaturation at 75 °C for 40 min. Electromagnetic denaturation of the proteins of the virus may open doors to potential therapeutic or sanitation applications.Pooya AfaghiMichael Anthony LapollaKhashayar GhandiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pooya Afaghi Michael Anthony Lapolla Khashayar Ghandi Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation
description	Abstract SARS-CoV-2, the virus that causes COVID-19, is still a widespread threat to society. The spike protein of this virus facilitates viral entry into the host cell. Here, the denaturation of the S1 subunit of this spike protein by 2.45 GHz electromagnetic radiation was studied quantitatively. The study only pertains to the pure electromagnetic effects by eliminating the bulk heating effect of the microwave radiation in an innovative setup that is capable of controlling the temperature of the sample at any desired intensity of the electromagnetic field. This study was performed at the internal human body temperature, 37 °C, for a relatively short amount of time under a high-power electromagnetic field. The results showed that irradiating the protein with a 700 W, 2.45 GHz electromagnetic field for 2 min can denature the protein to around 95%. In comparison, this is comparable to thermal denaturation at 75 °C for 40 min. Electromagnetic denaturation of the proteins of the virus may open doors to potential therapeutic or sanitation applications.
format	article
author	Pooya Afaghi Michael Anthony Lapolla Khashayar Ghandi
author_facet	Pooya Afaghi Michael Anthony Lapolla Khashayar Ghandi
author_sort	Pooya Afaghi
title	Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation
title_short	Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation
title_full	Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation
title_fullStr	Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation
title_full_unstemmed	Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation
title_sort	denaturation of the sars-cov-2 spike protein under non-thermal microwave radiation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59951e7f8fa84bda84d5838c78f56ed6
work_keys_str_mv	AT pooyaafaghi denaturationofthesarscov2spikeproteinundernonthermalmicrowaveradiation AT michaelanthonylapolla denaturationofthesarscov2spikeproteinundernonthermalmicrowaveradiation AT khashayarghandi denaturationofthesarscov2spikeproteinundernonthermalmicrowaveradiation
_version_	1718372133680185344

Denaturation of the SARS-CoV-2 spike protein under non-thermal microwave radiation

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