A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection

Rapid and selective methods for detecting and diagnosing Influenza viruses can be useful to prevent a possible new pandemic. Biosensors are highly sensitive and can be a simpler, faster, and cheaper method for rapid detection of Influenza being an alternative to conventional ELISA and PCR techniques...

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Autores principales:	Leticia Tessaro, Adriano Aquino, Anna Paula Azevedo de Carvalho, Carlos Adam Conte-Junior
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	AuNPs Influenza subtypes Virus detection SPR Morphology Optical detection Instruments and machines QA71-90
Acceso en línea:	https://doaj.org/article/59957fba45cf4ea0a9a57762a855aa91
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spelling	oai:doaj.org-article:59957fba45cf4ea0a9a57762a855aa912021-11-12T04:47:37ZA systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection2666-053910.1016/j.snr.2021.100060https://doaj.org/article/59957fba45cf4ea0a9a57762a855aa912021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666053921000357https://doaj.org/toc/2666-0539Rapid and selective methods for detecting and diagnosing Influenza viruses can be useful to prevent a possible new pandemic. Biosensors are highly sensitive and can be a simpler, faster, and cheaper method for rapid detection of Influenza being an alternative to conventional ELISA and PCR techniques. This study systematically searched and overviewed literature data related to gold nanoparticles (AuNPs)-based optical biosensors towards Influenza virus, retrieved from four databases, published between 2010 and 2021. We extracted data and critically analyzed the effect of Au-based nanomaterial type, functionalization, size, and morphology of AuNPs on sensitivity, and the effect of transducer type on detection limit (LOD). Although a direct relationship between AuNP size and LOD has not been noted, we found authors reporting a large variation in LOD according to morphology and transducer type. Spherical AuNP with an average diameter (AD) ranging from 10 to 100 nm, with better results for AD 80 nm. On the other hand, the increase in particle size impairs sensitivity in the bipyramids. Despite AuNPs and colorimetric detection are receiving attention from researchers, the most sensitive biosensor (LOD of 0.1 pg.mL−1) used a hybrid system (AuNPs-decorated carbon nanotubes) and photoluminescent detection. Furthermore, we showed the high specificity of AuNPs-optical biosensors in point-of-care (POC) diagnostic devices as a faster and cheaper approach for clinical diagnosis. Finally, we presented perspectives, future research, and opportunities including computational biosensors, AuNPs-hybrids, and synthesis approaches to improve biosensor's stability, sensitivity, and selectivity for rapid detection of influenza in clinical samples.Leticia TessaroAdriano AquinoAnna Paula Azevedo de CarvalhoCarlos Adam Conte-JuniorElsevierarticleAuNPsInfluenza subtypesVirus detectionSPRMorphologyOptical detectionInstruments and machinesQA71-90ENSensors and Actuators Reports, Vol 3, Iss , Pp 100060- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AuNPs Influenza subtypes Virus detection SPR Morphology Optical detection Instruments and machines QA71-90
spellingShingle	AuNPs Influenza subtypes Virus detection SPR Morphology Optical detection Instruments and machines QA71-90 Leticia Tessaro Adriano Aquino Anna Paula Azevedo de Carvalho Carlos Adam Conte-Junior A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection
description	Rapid and selective methods for detecting and diagnosing Influenza viruses can be useful to prevent a possible new pandemic. Biosensors are highly sensitive and can be a simpler, faster, and cheaper method for rapid detection of Influenza being an alternative to conventional ELISA and PCR techniques. This study systematically searched and overviewed literature data related to gold nanoparticles (AuNPs)-based optical biosensors towards Influenza virus, retrieved from four databases, published between 2010 and 2021. We extracted data and critically analyzed the effect of Au-based nanomaterial type, functionalization, size, and morphology of AuNPs on sensitivity, and the effect of transducer type on detection limit (LOD). Although a direct relationship between AuNP size and LOD has not been noted, we found authors reporting a large variation in LOD according to morphology and transducer type. Spherical AuNP with an average diameter (AD) ranging from 10 to 100 nm, with better results for AD 80 nm. On the other hand, the increase in particle size impairs sensitivity in the bipyramids. Despite AuNPs and colorimetric detection are receiving attention from researchers, the most sensitive biosensor (LOD of 0.1 pg.mL−1) used a hybrid system (AuNPs-decorated carbon nanotubes) and photoluminescent detection. Furthermore, we showed the high specificity of AuNPs-optical biosensors in point-of-care (POC) diagnostic devices as a faster and cheaper approach for clinical diagnosis. Finally, we presented perspectives, future research, and opportunities including computational biosensors, AuNPs-hybrids, and synthesis approaches to improve biosensor's stability, sensitivity, and selectivity for rapid detection of influenza in clinical samples.
format	article
author	Leticia Tessaro Adriano Aquino Anna Paula Azevedo de Carvalho Carlos Adam Conte-Junior
author_facet	Leticia Tessaro Adriano Aquino Anna Paula Azevedo de Carvalho Carlos Adam Conte-Junior
author_sort	Leticia Tessaro
title	A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection
title_short	A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection
title_full	A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection
title_fullStr	A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection
title_full_unstemmed	A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection
title_sort	systematic review on gold nanoparticles based-optical biosensors for influenza virus detection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/59957fba45cf4ea0a9a57762a855aa91
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A systematic review on gold nanoparticles based-optical biosensors for Influenza virus detection

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