Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

RAD51 assembly on single-stranded DNAs is an important step in the homology-dependent repair of DNA damage. Here authors reveal a role for the human RAD51 paralogue, SWSAP1, as a regulator of RAD51 assembly, by antagonizing RAD51 remodeller, FIGNL1 AAA + ATPase.

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Autores principales:	Kenichiro Matsuzaki, Shizuka Kondo, Tatsuya Ishikawa, Akira Shinohara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/599947bef88f47daa79b80f245df3a4e
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spelling	oai:doaj.org-article:599947bef88f47daa79b80f245df3a4e2021-12-02T14:35:31ZHuman RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase10.1038/s41467-019-09190-12041-1723https://doaj.org/article/599947bef88f47daa79b80f245df3a4e2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09190-1https://doaj.org/toc/2041-1723RAD51 assembly on single-stranded DNAs is an important step in the homology-dependent repair of DNA damage. Here authors reveal a role for the human RAD51 paralogue, SWSAP1, as a regulator of RAD51 assembly, by antagonizing RAD51 remodeller, FIGNL1 AAA + ATPase.Kenichiro MatsuzakiShizuka KondoTatsuya IshikawaAkira ShinoharaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kenichiro Matsuzaki Shizuka Kondo Tatsuya Ishikawa Akira Shinohara Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
description	RAD51 assembly on single-stranded DNAs is an important step in the homology-dependent repair of DNA damage. Here authors reveal a role for the human RAD51 paralogue, SWSAP1, as a regulator of RAD51 assembly, by antagonizing RAD51 remodeller, FIGNL1 AAA + ATPase.
format	article
author	Kenichiro Matsuzaki Shizuka Kondo Tatsuya Ishikawa Akira Shinohara
author_facet	Kenichiro Matsuzaki Shizuka Kondo Tatsuya Ishikawa Akira Shinohara
author_sort	Kenichiro Matsuzaki
title	Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
title_short	Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
title_full	Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
title_fullStr	Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
title_full_unstemmed	Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase
title_sort	human rad51 paralogue swsap1 fosters rad51 filament by regulating the anti-recombinase fignl1 aaa+ atpase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/599947bef88f47daa79b80f245df3a4e
work_keys_str_mv	AT kenichiromatsuzaki humanrad51paralogueswsap1fostersrad51filamentbyregulatingtheantirecombinasefignl1aaaatpase AT shizukakondo humanrad51paralogueswsap1fostersrad51filamentbyregulatingtheantirecombinasefignl1aaaatpase AT tatsuyaishikawa humanrad51paralogueswsap1fostersrad51filamentbyregulatingtheantirecombinasefignl1aaaatpase AT akirashinohara humanrad51paralogueswsap1fostersrad51filamentbyregulatingtheantirecombinasefignl1aaaatpase
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Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

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