'In silico' toxicology methods in drug safety assessment
While experimental animal investigation has historically been the most conventional approach conducted to assess drug safety and is currently considered the main method for determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over the last 20 years, there ha...
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2021
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oai:doaj.org-article:599af345e7b847f1b69859fde706730f2021-12-05T18:01:35Z'In silico' toxicology methods in drug safety assessment0004-19632217-876710.5937/arhfarm71-32966https://doaj.org/article/599af345e7b847f1b69859fde706730f2021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2021/0004-19632104257Q.pdfhttps://doaj.org/toc/0004-1963https://doaj.org/toc/2217-8767While experimental animal investigation has historically been the most conventional approach conducted to assess drug safety and is currently considered the main method for determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over the last 20 years, there have been significant advances in computational sciences and computer data processing, while knowledge of alternative techniques and their application has developed into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety assessment is constantly increasing. They are very complex and are grounded on accumulated knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as molecular biology. This review will summarize current state-of-the-art scientific data on the use of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting the strategies that should deliver consistent results, while covering the applications of in silico methods in preclinical trials and drug impurities toxicity testing.Đukić-Ćosić DanijelaBaralić KatarinaJorgovanović DragicaŽivančević KatarinaJavorac DraganaStojilković NikolaRadović BiljanaMarić ĐurđicaĆurčić MarijanaBuha-Đorđević AleksandraBulat ZoricaAntonijević-Miljaković EvicaAntonijević BiljanaPharmaceutical Association of Serbia, Belgrade, Serbiaarticlesoftwaredatabasesdrug preclinical trialsdrug impuritiessafety assessmentPharmacy and materia medicaRS1-441SRArhiv za farmaciju, Vol 71, Iss 4, Pp 257-278 (2021) |
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software databases drug preclinical trials drug impurities safety assessment Pharmacy and materia medica RS1-441 |
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software databases drug preclinical trials drug impurities safety assessment Pharmacy and materia medica RS1-441 Đukić-Ćosić Danijela Baralić Katarina Jorgovanović Dragica Živančević Katarina Javorac Dragana Stojilković Nikola Radović Biljana Marić Đurđica Ćurčić Marijana Buha-Đorđević Aleksandra Bulat Zorica Antonijević-Miljaković Evica Antonijević Biljana 'In silico' toxicology methods in drug safety assessment |
| description |
While experimental animal investigation has historically been the most conventional approach conducted to assess drug safety and is currently considered the main method for determining drug toxicity, these studies are constricted by cost, time, and ethical approvals. Over the last 20 years, there have been significant advances in computational sciences and computer data processing, while knowledge of alternative techniques and their application has developed into a valuable skill in toxicology. Thus, the application of in silico methods in drug safety assessment is constantly increasing. They are very complex and are grounded on accumulated knowledge from toxicology, bioinformatics, biochemistry, statistics, mathematics, as well as molecular biology. This review will summarize current state-of-the-art scientific data on the use of in silico methods in toxicity testing, taking into account their shortcomings, and highlighting the strategies that should deliver consistent results, while covering the applications of in silico methods in preclinical trials and drug impurities toxicity testing. |
| format |
article |
| author |
Đukić-Ćosić Danijela Baralić Katarina Jorgovanović Dragica Živančević Katarina Javorac Dragana Stojilković Nikola Radović Biljana Marić Đurđica Ćurčić Marijana Buha-Đorđević Aleksandra Bulat Zorica Antonijević-Miljaković Evica Antonijević Biljana |
| author_facet |
Đukić-Ćosić Danijela Baralić Katarina Jorgovanović Dragica Živančević Katarina Javorac Dragana Stojilković Nikola Radović Biljana Marić Đurđica Ćurčić Marijana Buha-Đorđević Aleksandra Bulat Zorica Antonijević-Miljaković Evica Antonijević Biljana |
| author_sort |
Đukić-Ćosić Danijela |
| title |
'In silico' toxicology methods in drug safety assessment |
| title_short |
'In silico' toxicology methods in drug safety assessment |
| title_full |
'In silico' toxicology methods in drug safety assessment |
| title_fullStr |
'In silico' toxicology methods in drug safety assessment |
| title_full_unstemmed |
'In silico' toxicology methods in drug safety assessment |
| title_sort |
'in silico' toxicology methods in drug safety assessment |
| publisher |
Pharmaceutical Association of Serbia, Belgrade, Serbia |
| publishDate |
2021 |
| url |
https://doaj.org/article/599af345e7b847f1b69859fde706730f |
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