Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

A soluble form E-cadherin is highly expressed in ovarian cancer. Here, the authors show that soluble E-cadherin is released by ovarian cancer cells packaged in exosomes and promotes tumor angiogenesis through β-catenin and NFkB signaling activation.

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Autores principales:	Maggie K. S. Tang, Patrick Y. K. Yue, Philip P. Ip, Rui-Lan Huang, Hung-Cheng Lai, Annie N. Y. Cheung, Ka Yu Tse, Hextan Y. S. Ngan, Alice S. T. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/599dda1639f747589df0acf5f4d2b966
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spelling	oai:doaj.org-article:599dda1639f747589df0acf5f4d2b9662021-12-02T14:38:48ZSoluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface10.1038/s41467-018-04695-72041-1723https://doaj.org/article/599dda1639f747589df0acf5f4d2b9662018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04695-7https://doaj.org/toc/2041-1723A soluble form E-cadherin is highly expressed in ovarian cancer. Here, the authors show that soluble E-cadherin is released by ovarian cancer cells packaged in exosomes and promotes tumor angiogenesis through β-catenin and NFkB signaling activation.Maggie K. S. TangPatrick Y. K. YuePhilip P. IpRui-Lan HuangHung-Cheng LaiAnnie N. Y. CheungKa Yu TseHextan Y. S. NganAlice S. T. WongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maggie K. S. Tang Patrick Y. K. Yue Philip P. Ip Rui-Lan Huang Hung-Cheng Lai Annie N. Y. Cheung Ka Yu Tse Hextan Y. S. Ngan Alice S. T. Wong Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
description	A soluble form E-cadherin is highly expressed in ovarian cancer. Here, the authors show that soluble E-cadherin is released by ovarian cancer cells packaged in exosomes and promotes tumor angiogenesis through β-catenin and NFkB signaling activation.
format	article
author	Maggie K. S. Tang Patrick Y. K. Yue Philip P. Ip Rui-Lan Huang Hung-Cheng Lai Annie N. Y. Cheung Ka Yu Tse Hextan Y. S. Ngan Alice S. T. Wong
author_facet	Maggie K. S. Tang Patrick Y. K. Yue Philip P. Ip Rui-Lan Huang Hung-Cheng Lai Annie N. Y. Cheung Ka Yu Tse Hextan Y. S. Ngan Alice S. T. Wong
author_sort	Maggie K. S. Tang
title	Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
title_short	Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
title_full	Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
title_fullStr	Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
title_full_unstemmed	Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface
title_sort	soluble e-cadherin promotes tumor angiogenesis and localizes to exosome surface
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/599dda1639f747589df0acf5f4d2b966
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Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface

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