Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets tumour associated macrophages.

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Autores principales:	Mingzhu Yin, Ying Guo, Rui Hu, Wesley L. Cai, Yao Li, Shiyao Pei, Hongyin Sun, Cong Peng, Jiali Li, Rui Ye, Qiaohong Yang, Nenghui Wang, Yongguang Tao, Xiang Chen, Qin Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59a306de0a994d95ae774f48771aeb95
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spelling	oai:doaj.org-article:59a306de0a994d95ae774f48771aeb952021-12-02T14:40:53ZPotent BRD4 inhibitor suppresses cancer cell-macrophage interaction10.1038/s41467-020-15290-02041-1723https://doaj.org/article/59a306de0a994d95ae774f48771aeb952020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15290-0https://doaj.org/toc/2041-1723Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets tumour associated macrophages.Mingzhu YinYing GuoRui HuWesley L. CaiYao LiShiyao PeiHongyin SunCong PengJiali LiRui YeQiaohong YangNenghui WangYongguang TaoXiang ChenQin YanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mingzhu Yin Ying Guo Rui Hu Wesley L. Cai Yao Li Shiyao Pei Hongyin Sun Cong Peng Jiali Li Rui Ye Qiaohong Yang Nenghui Wang Yongguang Tao Xiang Chen Qin Yan Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
description	Inhibitors of the BET family proteins are limited by their potency and oral bio-availability. Here, the authors report a new BET inhibitor, NHWD-870, with improved potency compared to previous BET inhibitors, and show that it suppresses BRD4 and targets tumour associated macrophages.
format	article
author	Mingzhu Yin Ying Guo Rui Hu Wesley L. Cai Yao Li Shiyao Pei Hongyin Sun Cong Peng Jiali Li Rui Ye Qiaohong Yang Nenghui Wang Yongguang Tao Xiang Chen Qin Yan
author_facet	Mingzhu Yin Ying Guo Rui Hu Wesley L. Cai Yao Li Shiyao Pei Hongyin Sun Cong Peng Jiali Li Rui Ye Qiaohong Yang Nenghui Wang Yongguang Tao Xiang Chen Qin Yan
author_sort	Mingzhu Yin
title	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_short	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_full	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_fullStr	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_full_unstemmed	Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction
title_sort	potent brd4 inhibitor suppresses cancer cell-macrophage interaction
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/59a306de0a994d95ae774f48771aeb95
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Potent BRD4 inhibitor suppresses cancer cell-macrophage interaction

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