MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer

Megakaryocytic leukemia 1 (MKL1) acts as a transcription factor in the regulation of the immune system and is associated with cancer biology. However, its function in the infiltrating immune cells in breast cancer has not been explored. Our study aimed to analyze the expression of MKL1 in The Cance...

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Autores principales:	Yijia Hua, Mengzhu Yang
Formato:	article
Lenguaje:	EN
Publicado:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021
Materias:	MKL1 breast cancer immune cell infiltration chemosensitivity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/59a35e43729f4a5da8df665a8ea598c7
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spelling	oai:doaj.org-article:59a35e43729f4a5da8df665a8ea598c72021-11-11T17:17:07ZMKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer10.17305/bjbms.2021.63061512-86011840-4812https://doaj.org/article/59a35e43729f4a5da8df665a8ea598c72021-11-01T00:00:00Zhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/6306https://doaj.org/toc/1512-8601https://doaj.org/toc/1840-4812 Megakaryocytic leukemia 1 (MKL1) acts as a transcription factor in the regulation of the immune system and is associated with cancer biology. However, its function in the infiltrating immune cells in breast cancer has not been explored. Our study aimed to analyze the expression of MKL1 in The Cancer Genome Atlas (TCGA) breast cancer dataset. The aim of this study was to evaluate the correlations between MKL1 expression, infiltrating immune cells, and immune control genes. Enriched signaling pathways and drug sensitivity analyses were also performed. Our results indicate that high MKL1 expression could predict better survival in breast cancer patients. MKL1 expression was associated with the expression and function of different immune cells, including T cells, B cells, natural killer (NK) cells, macrophages, neutrophils and dendritic cells (DCs). The chromatin modifying enzymes, cellular senescence, epigenetic regulation of gene expression, estrogen-dependent gene expression, and chromosome maintenance were differentially enriched in MKL1 low expression phenotype. Patients in the high MKL1 expression group showed sensitivity to paclitaxel, while those in the low expression group showed potential sensitivity for cisplatin and docetaxel. In conclusion, MKL1 might act as a potential biomarker of prognostic value for immune infiltration and drug sensitivity in breast cancer. Yijia HuaMengzhu YangAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaarticleMKL1breast cancerimmune cell infiltrationchemosensitivityMedicine (General)R5-920ENBosnian Journal of Basic Medical Sciences (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MKL1 breast cancer immune cell infiltration chemosensitivity Medicine (General) R5-920
spellingShingle	MKL1 breast cancer immune cell infiltration chemosensitivity Medicine (General) R5-920 Yijia Hua Mengzhu Yang MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
description	Megakaryocytic leukemia 1 (MKL1) acts as a transcription factor in the regulation of the immune system and is associated with cancer biology. However, its function in the infiltrating immune cells in breast cancer has not been explored. Our study aimed to analyze the expression of MKL1 in The Cancer Genome Atlas (TCGA) breast cancer dataset. The aim of this study was to evaluate the correlations between MKL1 expression, infiltrating immune cells, and immune control genes. Enriched signaling pathways and drug sensitivity analyses were also performed. Our results indicate that high MKL1 expression could predict better survival in breast cancer patients. MKL1 expression was associated with the expression and function of different immune cells, including T cells, B cells, natural killer (NK) cells, macrophages, neutrophils and dendritic cells (DCs). The chromatin modifying enzymes, cellular senescence, epigenetic regulation of gene expression, estrogen-dependent gene expression, and chromosome maintenance were differentially enriched in MKL1 low expression phenotype. Patients in the high MKL1 expression group showed sensitivity to paclitaxel, while those in the low expression group showed potential sensitivity for cisplatin and docetaxel. In conclusion, MKL1 might act as a potential biomarker of prognostic value for immune infiltration and drug sensitivity in breast cancer.
format	article
author	Yijia Hua Mengzhu Yang
author_facet	Yijia Hua Mengzhu Yang
author_sort	Yijia Hua
title	MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
title_short	MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
title_full	MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
title_fullStr	MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
title_full_unstemmed	MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
title_sort	mkl1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer
publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
publishDate	2021
url	https://doaj.org/article/59a35e43729f4a5da8df665a8ea598c7
work_keys_str_mv	AT yijiahua mkl1isakeybiomarkercorrelatedwithimmuneinfiltratesandchemosensitivityinbreastcancer AT mengzhuyang mkl1isakeybiomarkercorrelatedwithimmuneinfiltratesandchemosensitivityinbreastcancer
_version_	1718432118383575040

MKL1 is a key biomarker correlated with immune infiltrates and chemosensitivity in breast cancer

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