CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain

Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond res...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroshi Horiuchi, Masakazu Agetsuma, Junko Ishida, Yusuke Nakamura, Dennis Lawrence Cheung, Shin Nanasaki, Yasuyuki Kimura, Tatsuya Iwata, Kazuhiro Takahashi, Kazuaki Sawada, Junichi Nabekura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59a36f71f0184c4192ca29170b222301
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:59a36f71f0184c4192ca29170b222301
record_format	dspace
spelling	oai:doaj.org-article:59a36f71f0184c4192ca29170b2223012021-12-02T14:43:01ZCMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain10.1038/s41467-020-14571-y2041-1723https://doaj.org/article/59a36f71f0184c4192ca29170b2223012020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14571-yhttps://doaj.org/toc/2041-1723Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales.Hiroshi HoriuchiMasakazu AgetsumaJunko IshidaYusuke NakamuraDennis Lawrence CheungShin NanasakiYasuyuki KimuraTatsuya IwataKazuhiro TakahashiKazuaki SawadaJunichi NabekuraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroshi Horiuchi Masakazu Agetsuma Junko Ishida Yusuke Nakamura Dennis Lawrence Cheung Shin Nanasaki Yasuyuki Kimura Tatsuya Iwata Kazuhiro Takahashi Kazuaki Sawada Junichi Nabekura CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
description	Protons have been discovered to play a role in neuronal signaling, but current methods to measure pH in the brain of animal models are limited. Here the authors develop a miniaturized proton image sensor that fits into a living mouse brain and can measure pH changes at micrometer and millisecond resolution scales.
format	article
author	Hiroshi Horiuchi Masakazu Agetsuma Junko Ishida Yusuke Nakamura Dennis Lawrence Cheung Shin Nanasaki Yasuyuki Kimura Tatsuya Iwata Kazuhiro Takahashi Kazuaki Sawada Junichi Nabekura
author_facet	Hiroshi Horiuchi Masakazu Agetsuma Junko Ishida Yusuke Nakamura Dennis Lawrence Cheung Shin Nanasaki Yasuyuki Kimura Tatsuya Iwata Kazuhiro Takahashi Kazuaki Sawada Junichi Nabekura
author_sort	Hiroshi Horiuchi
title	CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
title_short	CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
title_full	CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
title_fullStr	CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
title_full_unstemmed	CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
title_sort	cmos-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/59a36f71f0184c4192ca29170b222301
work_keys_str_mv	AT hiroshihoriuchi cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT masakazuagetsuma cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT junkoishida cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT yusukenakamura cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT dennislawrencecheung cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT shinnanasaki cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT yasuyukikimura cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT tatsuyaiwata cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT kazuhirotakahashi cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT kazuakisawada cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain AT junichinabekura cmosbasedbioimagesensorspatiallyresolvesneuralactivitydependentprotondynamicsinthelivingbrain
_version_	1718389569314881536

CMOS-based bio-image sensor spatially resolves neural activity-dependent proton dynamics in the living brain

Ejemplares similares