Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study

Abstract Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD). However, alterations of remitted BD (RBD) in functional connectivity between the cerebral hemispheres are still not well understood. This study was designed...

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Autores principales:	Lianping Zhao, Ying Wang, Yanbin Jia, Shuming Zhong, Yao Sun, Zhangzhang Qi, Zhongping Zhang, Li Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59a4538a4b8b41b7ab835c9554bea915
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spelling	oai:doaj.org-article:59a4538a4b8b41b7ab835c9554bea9152021-12-02T12:30:45ZAltered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study10.1038/s41598-017-04937-62045-2322https://doaj.org/article/59a4538a4b8b41b7ab835c9554bea9152017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04937-6https://doaj.org/toc/2045-2322Abstract Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD). However, alterations of remitted BD (RBD) in functional connectivity between the cerebral hemispheres are still not well understood. This study was designed to analyze the pattern of the interhemispheric functional connectivity of the whole brain in patients with remitted BD during resting state. Twenty patients with RBD and 38 healthy controls (HC) underwent the resting-state functional magnetic resonance imaging. The functional connectivity between any pair of symmetrical interhemispheric voxels (i.e., functional homotopy) was measured by voxel-mirrored homotopic connectivity (VMHC). The patients with RBD showed lower VMHC than HC in the middle frontal gyrus and precentral gyrus. No regions of increased VMHC were detected in the RBD patients. There were no significant correlations between the VMHC values in these regions and the clinical variables. These findings suggest substantial impairment of interhemispheric coordination in RBD and they may represent trait, rather than state, neurobiological feature of brain function in BD.Lianping ZhaoYing WangYanbin JiaShuming ZhongYao SunZhangzhang QiZhongping ZhangLi HuangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lianping Zhao Ying Wang Yanbin Jia Shuming Zhong Yao Sun Zhangzhang Qi Zhongping Zhang Li Huang Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study
description	Abstract Abnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD). However, alterations of remitted BD (RBD) in functional connectivity between the cerebral hemispheres are still not well understood. This study was designed to analyze the pattern of the interhemispheric functional connectivity of the whole brain in patients with remitted BD during resting state. Twenty patients with RBD and 38 healthy controls (HC) underwent the resting-state functional magnetic resonance imaging. The functional connectivity between any pair of symmetrical interhemispheric voxels (i.e., functional homotopy) was measured by voxel-mirrored homotopic connectivity (VMHC). The patients with RBD showed lower VMHC than HC in the middle frontal gyrus and precentral gyrus. No regions of increased VMHC were detected in the RBD patients. There were no significant correlations between the VMHC values in these regions and the clinical variables. These findings suggest substantial impairment of interhemispheric coordination in RBD and they may represent trait, rather than state, neurobiological feature of brain function in BD.
format	article
author	Lianping Zhao Ying Wang Yanbin Jia Shuming Zhong Yao Sun Zhangzhang Qi Zhongping Zhang Li Huang
author_facet	Lianping Zhao Ying Wang Yanbin Jia Shuming Zhong Yao Sun Zhangzhang Qi Zhongping Zhang Li Huang
author_sort	Lianping Zhao
title	Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study
title_short	Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study
title_full	Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study
title_fullStr	Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study
title_full_unstemmed	Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study
title_sort	altered interhemispheric functional connectivity in remitted bipolar disorder: a resting state fmri study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/59a4538a4b8b41b7ab835c9554bea915
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Altered interhemispheric functional connectivity in remitted bipolar disorder: A Resting State fMRI Study

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