Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites

Abstract In primates, large layer V pyramidal neurons located in the frontal motor-related areas send a variety of motor commands to the spinal cord, giving rise to the corticospinal tract, for execution of skilled motor behavior. However, little is known about the morphological diversity of such py...

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Autores principales:	Yu Takata, Hiroshi Nakagawa, Taihei Ninomiya, Hajime Yamanaka, Masahiko Takada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59a4eea6cf8c457b8a070507992a90aa
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spelling	oai:doaj.org-article:59a4eea6cf8c457b8a070507992a90aa2021-12-02T12:11:52ZMorphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites10.1038/s41598-021-83680-52045-2322https://doaj.org/article/59a4eea6cf8c457b8a070507992a90aa2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83680-5https://doaj.org/toc/2045-2322Abstract In primates, large layer V pyramidal neurons located in the frontal motor-related areas send a variety of motor commands to the spinal cord, giving rise to the corticospinal tract, for execution of skilled motor behavior. However, little is known about the morphological diversity of such pyramidal neurons among the areas. Here we show that the structure of basal dendrites of the large layer V pyramidal neurons in the dorsal premotor cortex (PMd) is different from those in the other areas, including the primary motor cortex, the supplementary motor area, and the ventral premotor cortex. In the PMd, not only the complexity (arborization) of basal dendrites, i.e., total dendritic length and branching number, was poorly developed, but also the density of dendritic spines was so low, as compared to the other motor-related areas. Regarding the distribution of the three dendritic spine types identified, we found that thin-type (more immature) spines were prominent in the PMd in comparison with stubby- and mushroom-type (more mature) spines, while both thin- and stubby-type spines were in the other areas. The differential morphological features of basal dendrites might reflect distinct patterns of motor information processing within the large layer V pyramidal neurons in individual motor-related areas.Yu TakataHiroshi NakagawaTaihei NinomiyaHajime YamanakaMasahiko TakadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Takata Hiroshi Nakagawa Taihei Ninomiya Hajime Yamanaka Masahiko Takada Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
description	Abstract In primates, large layer V pyramidal neurons located in the frontal motor-related areas send a variety of motor commands to the spinal cord, giving rise to the corticospinal tract, for execution of skilled motor behavior. However, little is known about the morphological diversity of such pyramidal neurons among the areas. Here we show that the structure of basal dendrites of the large layer V pyramidal neurons in the dorsal premotor cortex (PMd) is different from those in the other areas, including the primary motor cortex, the supplementary motor area, and the ventral premotor cortex. In the PMd, not only the complexity (arborization) of basal dendrites, i.e., total dendritic length and branching number, was poorly developed, but also the density of dendritic spines was so low, as compared to the other motor-related areas. Regarding the distribution of the three dendritic spine types identified, we found that thin-type (more immature) spines were prominent in the PMd in comparison with stubby- and mushroom-type (more mature) spines, while both thin- and stubby-type spines were in the other areas. The differential morphological features of basal dendrites might reflect distinct patterns of motor information processing within the large layer V pyramidal neurons in individual motor-related areas.
format	article
author	Yu Takata Hiroshi Nakagawa Taihei Ninomiya Hajime Yamanaka Masahiko Takada
author_facet	Yu Takata Hiroshi Nakagawa Taihei Ninomiya Hajime Yamanaka Masahiko Takada
author_sort	Yu Takata
title	Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
title_short	Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
title_full	Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
title_fullStr	Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
title_full_unstemmed	Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
title_sort	morphological features of large layer v pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59a4eea6cf8c457b8a070507992a90aa
work_keys_str_mv	AT yutakata morphologicalfeaturesoflargelayervpyramidalneuronsincorticalmotorrelatedareasofmacaquemonkeysanalysisofbasaldendrites AT hiroshinakagawa morphologicalfeaturesoflargelayervpyramidalneuronsincorticalmotorrelatedareasofmacaquemonkeysanalysisofbasaldendrites AT taiheininomiya morphologicalfeaturesoflargelayervpyramidalneuronsincorticalmotorrelatedareasofmacaquemonkeysanalysisofbasaldendrites AT hajimeyamanaka morphologicalfeaturesoflargelayervpyramidalneuronsincorticalmotorrelatedareasofmacaquemonkeysanalysisofbasaldendrites AT masahikotakada morphologicalfeaturesoflargelayervpyramidalneuronsincorticalmotorrelatedareasofmacaquemonkeysanalysisofbasaldendrites
_version_	1718394575767207936

Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites

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