INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endosome formation and trafficking that leads to the acti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Samuel J. Rodgers, Lisa M. Ooms, Viola M. J. Oorschot, Ralf B. Schittenhelm, Elizabeth V. Nguyen, Sabryn A. Hamila, Natalie Rynkiewicz, Rajendra Gurung, Matthew J. Eramo, Absorn Sriratana, Clare G. Fedele, Franco Caramia, Sherene Loi, Genevieve Kerr, Helen E. Abud, Georg Ramm, Antonella Papa, Andrew M. Ellisdon, Roger J. Daly, Catriona A. McLean, Christina A. Mitchell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:59a5e5fde3fd4918b764c6ce08708383
record_format	dspace
spelling	oai:doaj.org-article:59a5e5fde3fd4918b764c6ce087083832021-12-02T15:49:52ZINPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer10.1038/s41467-021-23241-62041-1723https://doaj.org/article/59a5e5fde3fd4918b764c6ce087083832021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23241-6https://doaj.org/toc/2041-1723The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endosome formation and trafficking that leads to the activation of Wnt/β-catenin signalling.Samuel J. RodgersLisa M. OomsViola M. J. OorschotRalf B. SchittenhelmElizabeth V. NguyenSabryn A. HamilaNatalie RynkiewiczRajendra GurungMatthew J. EramoAbsorn SriratanaClare G. FedeleFranco CaramiaSherene LoiGenevieve KerrHelen E. AbudGeorg RammAntonella PapaAndrew M. EllisdonRoger J. DalyCatriona A. McLeanChristina A. MitchellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Samuel J. Rodgers Lisa M. Ooms Viola M. J. Oorschot Ralf B. Schittenhelm Elizabeth V. Nguyen Sabryn A. Hamila Natalie Rynkiewicz Rajendra Gurung Matthew J. Eramo Absorn Sriratana Clare G. Fedele Franco Caramia Sherene Loi Genevieve Kerr Helen E. Abud Georg Ramm Antonella Papa Andrew M. Ellisdon Roger J. Daly Catriona A. McLean Christina A. Mitchell INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
description	The PI(3,4)P2 4-phosphatase, INPP4B, functions as a tumour suppressor in triple negative breast cancer. Here, the authors show that INPP4B enhances proliferation and growth of PIK3CA-mutant ER+ breast cancers by promoting PI3Kα-dependent late endosome formation and trafficking that leads to the activation of Wnt/β-catenin signalling.
format	article
author	Samuel J. Rodgers Lisa M. Ooms Viola M. J. Oorschot Ralf B. Schittenhelm Elizabeth V. Nguyen Sabryn A. Hamila Natalie Rynkiewicz Rajendra Gurung Matthew J. Eramo Absorn Sriratana Clare G. Fedele Franco Caramia Sherene Loi Genevieve Kerr Helen E. Abud Georg Ramm Antonella Papa Andrew M. Ellisdon Roger J. Daly Catriona A. McLean Christina A. Mitchell
author_facet	Samuel J. Rodgers Lisa M. Ooms Viola M. J. Oorschot Ralf B. Schittenhelm Elizabeth V. Nguyen Sabryn A. Hamila Natalie Rynkiewicz Rajendra Gurung Matthew J. Eramo Absorn Sriratana Clare G. Fedele Franco Caramia Sherene Loi Genevieve Kerr Helen E. Abud Georg Ramm Antonella Papa Andrew M. Ellisdon Roger J. Daly Catriona A. McLean Christina A. Mitchell
author_sort	Samuel J. Rodgers
title	INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
title_short	INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
title_full	INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
title_fullStr	INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
title_full_unstemmed	INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
title_sort	inpp4b promotes pi3kα-dependent late endosome formation and wnt/β-catenin signaling in breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59a5e5fde3fd4918b764c6ce08708383
work_keys_str_mv	AT samueljrodgers inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT lisamooms inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT violamjoorschot inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT ralfbschittenhelm inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT elizabethvnguyen inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT sabrynahamila inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT natalierynkiewicz inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT rajendragurung inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT matthewjeramo inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT absornsriratana inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT claregfedele inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT francocaramia inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT shereneloi inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT genevievekerr inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT heleneabud inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT georgramm inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT antonellapapa inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT andrewmellisdon inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT rogerjdaly inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT catrionaamclean inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer AT christinaamitchell inpp4bpromotespi3kadependentlateendosomeformationandwntbcateninsignalinginbreastcancer
_version_	1718385690292518912

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

Ejemplares similares