Can we negotiate with a tumor?

Recent progress in deciphering the molecular portraits of tumors promises an era of more personalized drug choices. However, current protocols still follow standard fixed-time schedules, which is not entirely coherent with the common observation that most tumors do not grow continuously. This unpred...

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Autores principales:	Claire M Wolfrom, Michel Laurent, Jean Deschatrette
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59a69900c3f14479a3a08708ba1ae01f
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spelling	oai:doaj.org-article:59a69900c3f14479a3a08708ba1ae01f2021-11-25T06:06:18ZCan we negotiate with a tumor?1932-620310.1371/journal.pone.0103834https://doaj.org/article/59a69900c3f14479a3a08708ba1ae01f2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25084359/?tool=EBIhttps://doaj.org/toc/1932-6203Recent progress in deciphering the molecular portraits of tumors promises an era of more personalized drug choices. However, current protocols still follow standard fixed-time schedules, which is not entirely coherent with the common observation that most tumors do not grow continuously. This unpredictability of the increases in tumor mass is not necessarily an obstacle to therapeutic efficiency, particularly if tumor dynamics could be exploited. We propose a model of tumor mass evolution as the integrated result of the dynamics of two linked complex systems, tumor cell population and tumor microenvironment, and show the practical relevance of this nonlinear approach.Claire M WolfromMichel LaurentJean DeschatrettePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103834 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Claire M Wolfrom Michel Laurent Jean Deschatrette Can we negotiate with a tumor?
description	Recent progress in deciphering the molecular portraits of tumors promises an era of more personalized drug choices. However, current protocols still follow standard fixed-time schedules, which is not entirely coherent with the common observation that most tumors do not grow continuously. This unpredictability of the increases in tumor mass is not necessarily an obstacle to therapeutic efficiency, particularly if tumor dynamics could be exploited. We propose a model of tumor mass evolution as the integrated result of the dynamics of two linked complex systems, tumor cell population and tumor microenvironment, and show the practical relevance of this nonlinear approach.
format	article
author	Claire M Wolfrom Michel Laurent Jean Deschatrette
author_facet	Claire M Wolfrom Michel Laurent Jean Deschatrette
author_sort	Claire M Wolfrom
title	Can we negotiate with a tumor?
title_short	Can we negotiate with a tumor?
title_full	Can we negotiate with a tumor?
title_fullStr	Can we negotiate with a tumor?
title_full_unstemmed	Can we negotiate with a tumor?
title_sort	can we negotiate with a tumor?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/59a69900c3f14479a3a08708ba1ae01f
work_keys_str_mv	AT clairemwolfrom canwenegotiatewithatumor AT michellaurent canwenegotiatewithatumor AT jeandeschatrette canwenegotiatewithatumor
_version_	1718414163698515968

Can we negotiate with a tumor?

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