YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

YAP is known to play a role both in organ size via the Hippo signalling pathway and in inflammation, though the precise mechanism are unclear. Here, the authors report that YAP promotes activation of the NLRP3 inflammosome through binding interactions.

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Autores principales: Dan Wang, Yening Zhang, Xueming Xu, Jianfeng Wu, Yue Peng, Jing Li, Ruiheng Luo, Lingmin Huang, Liping Liu, Songlin Yu, Ningjie Zhang, Ben Lu, Kai Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/59a699453073469b985d1d094e855ff5
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spelling oai:doaj.org-article:59a699453073469b985d1d094e855ff52021-12-02T15:36:11ZYAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP310.1038/s41467-021-22987-32041-1723https://doaj.org/article/59a699453073469b985d1d094e855ff52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22987-3https://doaj.org/toc/2041-1723YAP is known to play a role both in organ size via the Hippo signalling pathway and in inflammation, though the precise mechanism are unclear. Here, the authors report that YAP promotes activation of the NLRP3 inflammosome through binding interactions.Dan WangYening ZhangXueming XuJianfeng WuYue PengJing LiRuiheng LuoLingmin HuangLiping LiuSonglin YuNingjie ZhangBen LuKai ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dan Wang
Yening Zhang
Xueming Xu
Jianfeng Wu
Yue Peng
Jing Li
Ruiheng Luo
Lingmin Huang
Liping Liu
Songlin Yu
Ningjie Zhang
Ben Lu
Kai Zhao
YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
description YAP is known to play a role both in organ size via the Hippo signalling pathway and in inflammation, though the precise mechanism are unclear. Here, the authors report that YAP promotes activation of the NLRP3 inflammosome through binding interactions.
format article
author Dan Wang
Yening Zhang
Xueming Xu
Jianfeng Wu
Yue Peng
Jing Li
Ruiheng Luo
Lingmin Huang
Liping Liu
Songlin Yu
Ningjie Zhang
Ben Lu
Kai Zhao
author_facet Dan Wang
Yening Zhang
Xueming Xu
Jianfeng Wu
Yue Peng
Jing Li
Ruiheng Luo
Lingmin Huang
Liping Liu
Songlin Yu
Ningjie Zhang
Ben Lu
Kai Zhao
author_sort Dan Wang
title YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
title_short YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
title_full YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
title_fullStr YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
title_full_unstemmed YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
title_sort yap promotes the activation of nlrp3 inflammasome via blocking k27-linked polyubiquitination of nlrp3
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/59a699453073469b985d1d094e855ff5
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