YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

YAP is known to play a role both in organ size via the Hippo signalling pathway and in inflammation, though the precise mechanism are unclear. Here, the authors report that YAP promotes activation of the NLRP3 inflammosome through binding interactions.

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Autores principales: Dan Wang, Yening Zhang, Xueming Xu, Jianfeng Wu, Yue Peng, Jing Li, Ruiheng Luo, Lingmin Huang, Liping Liu, Songlin Yu, Ningjie Zhang, Ben Lu, Kai Zhao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/59a699453073469b985d1d094e855ff5
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