Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery

Kerry D Solomon,1 Helga P Sandoval,1 Richard Potvin2 1Carolina Eyecare Physicians, Mt Pleasant, SC, USA; 2Science in Vision, Bend, OR, USACorrespondence: Kerry D SolomonCarolina Eyecare Physicians, LLC, 1101 Clarity Road, Suite 100, Mt Pleasant, SC 29464, USAEmail kerry.solomon@carolinaeyecare.comPu...

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Autores principales:	Solomon KD, Sandoval HP, Potvin R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	bromfenac sodium gatifloxacin prednisolone acetate combination drop Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/59a70045536a401f84878aa986373029
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spelling	oai:doaj.org-article:59a70045536a401f84878aa9863730292021-12-02T11:09:04ZComparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery1177-5483https://doaj.org/article/59a70045536a401f84878aa9863730292020-07-01T00:00:00Zhttps://www.dovepress.com/comparing-combination-drop-therapy-to-a-standard-drop-regimen-after-ro-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kerry D Solomon,1 Helga P Sandoval,1 Richard Potvin2 1Carolina Eyecare Physicians, Mt Pleasant, SC, USA; 2Science in Vision, Bend, OR, USACorrespondence: Kerry D SolomonCarolina Eyecare Physicians, LLC, 1101 Clarity Road, Suite 100, Mt Pleasant, SC 29464, USAEmail kerry.solomon@carolinaeyecare.comPurpose: To evaluate the efficacy of a combined steroid/antibiotic/non-steroidal anti-inflammatory drop relative to a regimen of multiple drops after cataract surgery.Setting: Single clinical practice in the USA.Design: Prospective randomized contralateral eye study.Methods: Subjects presenting for bilateral cataract surgery were enrolled with contralateral eyes randomly assigned to one of the two groups. Test eyes received a combination therapy (prednisolone acetate 1%, gatifloxacin 0.5%, and bromfenac sodium 0.075%) while control eyes received the same medications in separate drops (bromfenac sodium was 0.07%). Subjects were examined 1, 15 and 30 days after surgery. Visual acuities were measured, along with the refraction, intraocular pressure, patient pain and satisfaction, macular thickness and corneal pachymetry. The primary measure of interest was the change in macular thickness from baseline to the 15- and 30-day visits. The frequency and severity of reported ocular adverse events were tabulated for each group and compared.Results: Thirty-three subjects completed the study. Changes in central macular thickness were similar between groups, with only one control eye exhibiting significant macular edema. No differences in visual acuity, corneal edema, cells or flare were observed between groups. There were eight mild adverse events reported for all eyes of all subjects; the difference in the number of eyes experiencing adverse events was not statistically significantly different between groups (p ≥ 0.05 for all comparisons). While subjective symptoms were similar, all subjects indicated that they preferred the combination drop.Conclusion: A combination drop showed similar efficacy to multiple drops and was overwhelmingly preferred by subjects.Keywords: bromfenac sodium, gatifloxacin, prednisolone acetate, combination dropSolomon KDSandoval HPPotvin RDove Medical Pressarticlebromfenac sodiumgatifloxacinprednisolone acetatecombination dropOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1959-1965 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	bromfenac sodium gatifloxacin prednisolone acetate combination drop Ophthalmology RE1-994
spellingShingle	bromfenac sodium gatifloxacin prednisolone acetate combination drop Ophthalmology RE1-994 Solomon KD Sandoval HP Potvin R Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery
description	Kerry D Solomon,1 Helga P Sandoval,1 Richard Potvin2 1Carolina Eyecare Physicians, Mt Pleasant, SC, USA; 2Science in Vision, Bend, OR, USACorrespondence: Kerry D SolomonCarolina Eyecare Physicians, LLC, 1101 Clarity Road, Suite 100, Mt Pleasant, SC 29464, USAEmail kerry.solomon@carolinaeyecare.comPurpose: To evaluate the efficacy of a combined steroid/antibiotic/non-steroidal anti-inflammatory drop relative to a regimen of multiple drops after cataract surgery.Setting: Single clinical practice in the USA.Design: Prospective randomized contralateral eye study.Methods: Subjects presenting for bilateral cataract surgery were enrolled with contralateral eyes randomly assigned to one of the two groups. Test eyes received a combination therapy (prednisolone acetate 1%, gatifloxacin 0.5%, and bromfenac sodium 0.075%) while control eyes received the same medications in separate drops (bromfenac sodium was 0.07%). Subjects were examined 1, 15 and 30 days after surgery. Visual acuities were measured, along with the refraction, intraocular pressure, patient pain and satisfaction, macular thickness and corneal pachymetry. The primary measure of interest was the change in macular thickness from baseline to the 15- and 30-day visits. The frequency and severity of reported ocular adverse events were tabulated for each group and compared.Results: Thirty-three subjects completed the study. Changes in central macular thickness were similar between groups, with only one control eye exhibiting significant macular edema. No differences in visual acuity, corneal edema, cells or flare were observed between groups. There were eight mild adverse events reported for all eyes of all subjects; the difference in the number of eyes experiencing adverse events was not statistically significantly different between groups (p ≥ 0.05 for all comparisons). While subjective symptoms were similar, all subjects indicated that they preferred the combination drop.Conclusion: A combination drop showed similar efficacy to multiple drops and was overwhelmingly preferred by subjects.Keywords: bromfenac sodium, gatifloxacin, prednisolone acetate, combination drop
format	article
author	Solomon KD Sandoval HP Potvin R
author_facet	Solomon KD Sandoval HP Potvin R
author_sort	Solomon KD
title	Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery
title_short	Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery
title_full	Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery
title_fullStr	Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery
title_full_unstemmed	Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery
title_sort	comparing combination drop therapy to a standard drop regimen after routine cataract surgery
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/59a70045536a401f84878aa986373029
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Comparing Combination Drop Therapy to a Standard Drop Regimen After Routine Cataract Surgery

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