High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma

Over the years, molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status have been observed to effectively guide decision-making for the optimal treatment of patients with breast carcinoma (BRCA). However, despite thi...

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Autores principales:	Gaoda Ju, Cheng Xu, Kai Zeng, Tianhao Zhou, Lijuan Zang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	tmed9 breast carcinoma biomarker prognosis bioinformatics Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/59a7f861782b402a84825e51679dbc95
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spelling	oai:doaj.org-article:59a7f861782b402a84825e51679dbc952021-11-04T15:51:54ZHigh expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma2165-59792165-598710.1080/21655979.2021.1990673https://doaj.org/article/59a7f861782b402a84825e51679dbc952021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1990673https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Over the years, molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status have been observed to effectively guide decision-making for the optimal treatment of patients with breast carcinoma (BRCA). However, despite this progress, there are still more than 41,000 BRCA-related fatalities each year in the United States. Moreover, effective drug targets for triple-negative breast carcinoma (TNBC) are still lacking. Given its high mortality rate, it is necessary to investigate more biomarkers with prognostic and pathological relevance in BRCA. In our study, we examined the expression patterns and prognostic implications of transmembrane P24 trafficking protein 9 (TMED9) in BRCA using multiple public cohorts and BRCA specimens collected from Shanghai General Hospital. In addition to this, in vitro experiments were also performed to evaluate the effects of TMED9 expression in BRCA cell proliferation and migration. Our results have demonstrated that a high expression of TMED9 promoted BRCA cell proliferation and migration and predicted poor prognosis in patients with BRCA. In conclusion, TMED9 is a potential prognostic indicator and a possible drug target of BRCA.Gaoda JuCheng XuKai ZengTianhao ZhouLijuan ZangTaylor & Francis Grouparticletmed9breast carcinomabiomarkerprognosisbioinformaticsBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 8965-8979 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tmed9 breast carcinoma biomarker prognosis bioinformatics Biotechnology TP248.13-248.65
spellingShingle	tmed9 breast carcinoma biomarker prognosis bioinformatics Biotechnology TP248.13-248.65 Gaoda Ju Cheng Xu Kai Zeng Tianhao Zhou Lijuan Zang High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
description	Over the years, molecular subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER-2) status have been observed to effectively guide decision-making for the optimal treatment of patients with breast carcinoma (BRCA). However, despite this progress, there are still more than 41,000 BRCA-related fatalities each year in the United States. Moreover, effective drug targets for triple-negative breast carcinoma (TNBC) are still lacking. Given its high mortality rate, it is necessary to investigate more biomarkers with prognostic and pathological relevance in BRCA. In our study, we examined the expression patterns and prognostic implications of transmembrane P24 trafficking protein 9 (TMED9) in BRCA using multiple public cohorts and BRCA specimens collected from Shanghai General Hospital. In addition to this, in vitro experiments were also performed to evaluate the effects of TMED9 expression in BRCA cell proliferation and migration. Our results have demonstrated that a high expression of TMED9 promoted BRCA cell proliferation and migration and predicted poor prognosis in patients with BRCA. In conclusion, TMED9 is a potential prognostic indicator and a possible drug target of BRCA.
format	article
author	Gaoda Ju Cheng Xu Kai Zeng Tianhao Zhou Lijuan Zang
author_facet	Gaoda Ju Cheng Xu Kai Zeng Tianhao Zhou Lijuan Zang
author_sort	Gaoda Ju
title	High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
title_short	High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
title_full	High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
title_fullStr	High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
title_full_unstemmed	High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
title_sort	high expression of transmembrane p24 trafficking protein 9 predicts poor prognosis in breast carcinoma
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/59a7f861782b402a84825e51679dbc95
work_keys_str_mv	AT gaodaju highexpressionoftransmembranep24traffickingprotein9predictspoorprognosisinbreastcarcinoma AT chengxu highexpressionoftransmembranep24traffickingprotein9predictspoorprognosisinbreastcarcinoma AT kaizeng highexpressionoftransmembranep24traffickingprotein9predictspoorprognosisinbreastcarcinoma AT tianhaozhou highexpressionoftransmembranep24traffickingprotein9predictspoorprognosisinbreastcarcinoma AT lijuanzang highexpressionoftransmembranep24traffickingprotein9predictspoorprognosisinbreastcarcinoma
_version_	1718444715808915456

High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma

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