Microbiota‐derived extracellular vesicles in interkingdom communication in the gut

Abstract The intestine is fundamental in controlling human health. Intestinal epithelial and immune cells are continuously exposed to millions of microbes that greatly impact on intestinal epithelial barrier and immune function. This microbial community, known as gut microbiota, is now recognized as...

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Autores principales:	Natalia Díaz‐Garrido, Josefa Badia, Laura Baldomà
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	bacterial membrane vesicles gut microbiota gut permeability immune regulation intestinal homeostasis probiotics Cytology QH573-671
Acceso en línea:	https://doaj.org/article/59abc070141d4dd683715f28a2574328
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spelling	oai:doaj.org-article:59abc070141d4dd683715f28a25743282021-11-24T14:04:30ZMicrobiota‐derived extracellular vesicles in interkingdom communication in the gut2001-307810.1002/jev2.12161https://doaj.org/article/59abc070141d4dd683715f28a25743282021-11-01T00:00:00Zhttps://doi.org/10.1002/jev2.12161https://doaj.org/toc/2001-3078Abstract The intestine is fundamental in controlling human health. Intestinal epithelial and immune cells are continuously exposed to millions of microbes that greatly impact on intestinal epithelial barrier and immune function. This microbial community, known as gut microbiota, is now recognized as an important partner of the human being that actively contribute to essential functions of the intestine but also of distal organs. In the gut ecosystem, bidirectional microbiota‐host communication does not involve direct cell contacts. Both microbiota and host‐derived extracellular vesicles (EVs) are key players of such interkingdom crosstalk. There is now accumulating body of evidence that bacterial secreted vesicles mediate microbiota functions by transporting and delivering into host cells effector molecules that modulate host signalling pathways and cell processes. Consequently, vesicles released by the gut microbiota may have great influence on health and disease. Here we review current knowledge on microbiota EVs and specifically highlight their role in controlling host metabolism, intestinal barrier integrity and immune training.Natalia Díaz‐GarridoJosefa BadiaLaura BaldomàTaylor & Francis Grouparticlebacterial membrane vesiclesgut microbiotagut permeabilityimmune regulationintestinal homeostasisprobioticsCytologyQH573-671ENJournal of Extracellular Vesicles, Vol 10, Iss 13, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bacterial membrane vesicles gut microbiota gut permeability immune regulation intestinal homeostasis probiotics Cytology QH573-671
spellingShingle	bacterial membrane vesicles gut microbiota gut permeability immune regulation intestinal homeostasis probiotics Cytology QH573-671 Natalia Díaz‐Garrido Josefa Badia Laura Baldomà Microbiota‐derived extracellular vesicles in interkingdom communication in the gut
description	Abstract The intestine is fundamental in controlling human health. Intestinal epithelial and immune cells are continuously exposed to millions of microbes that greatly impact on intestinal epithelial barrier and immune function. This microbial community, known as gut microbiota, is now recognized as an important partner of the human being that actively contribute to essential functions of the intestine but also of distal organs. In the gut ecosystem, bidirectional microbiota‐host communication does not involve direct cell contacts. Both microbiota and host‐derived extracellular vesicles (EVs) are key players of such interkingdom crosstalk. There is now accumulating body of evidence that bacterial secreted vesicles mediate microbiota functions by transporting and delivering into host cells effector molecules that modulate host signalling pathways and cell processes. Consequently, vesicles released by the gut microbiota may have great influence on health and disease. Here we review current knowledge on microbiota EVs and specifically highlight their role in controlling host metabolism, intestinal barrier integrity and immune training.
format	article
author	Natalia Díaz‐Garrido Josefa Badia Laura Baldomà
author_facet	Natalia Díaz‐Garrido Josefa Badia Laura Baldomà
author_sort	Natalia Díaz‐Garrido
title	Microbiota‐derived extracellular vesicles in interkingdom communication in the gut
title_short	Microbiota‐derived extracellular vesicles in interkingdom communication in the gut
title_full	Microbiota‐derived extracellular vesicles in interkingdom communication in the gut
title_fullStr	Microbiota‐derived extracellular vesicles in interkingdom communication in the gut
title_full_unstemmed	Microbiota‐derived extracellular vesicles in interkingdom communication in the gut
title_sort	microbiota‐derived extracellular vesicles in interkingdom communication in the gut
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/59abc070141d4dd683715f28a2574328
work_keys_str_mv	AT nataliadiazgarrido microbiotaderivedextracellularvesiclesininterkingdomcommunicationinthegut AT josefabadia microbiotaderivedextracellularvesiclesininterkingdomcommunicationinthegut AT laurabaldoma microbiotaderivedextracellularvesiclesininterkingdomcommunicationinthegut
_version_	1718415047204536320

Microbiota‐derived extracellular vesicles in interkingdom communication in the gut

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