APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population

Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the His...

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Autores principales:	Stephanie Lozano, Victoria Padilla, Manuel Lee Avila, Mario Gil, Gladys Maestre, Kesheng Wang, Chun Xu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	APOE hypercholesteremia cardiovascular diseases dementia Genetics QH426-470
Acceso en línea:	https://doaj.org/article/59aca231e2f84d1abd050d5ec9f9ebcc
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spelling	oai:doaj.org-article:59aca231e2f84d1abd050d5ec9f9ebcc2021-11-25T17:41:43Z<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population10.3390/genes121117682073-4425https://doaj.org/article/59aca231e2f84d1abd050d5ec9f9ebcc2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1768https://doaj.org/toc/2073-4425Genetic variants in the apolipoprotein E (<i>APOE</i>) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the <i>APOE</i> gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene’s associations with cholesterol level and its related phenotypes. The <i>APOE</i> gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N = 62). Questionnaires on demographics, medical history, and blood/saliva samples were collected and <i>APOE</i> genotypes were performed. We observed allele frequencies of the <i>APOE</i> ε3 (96.7%), ε4 (22.6%) and ε2 (6.8%) alleles, respectively. Multivariable logistic regression revealed a significant association between the <i>APOE</i> ε4 allele and hypercholesteremia (<i>p</i> = 1.8 × 10<sup>−4</sup>) in our studied Hispanic population. We prove for the first time, that the APOE ε4 allele increases the risk for hypercholesterol in Hispanics. Further research is needed to confirm and supports our current findings.Stephanie LozanoVictoria PadillaManuel Lee AvilaMario GilGladys MaestreKesheng WangChun XuMDPI AGarticleAPOEhypercholesteremiacardiovascular diseasesdementiaGeneticsQH426-470ENGenes, Vol 12, Iss 1768, p 1768 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	APOE hypercholesteremia cardiovascular diseases dementia Genetics QH426-470
spellingShingle	APOE hypercholesteremia cardiovascular diseases dementia Genetics QH426-470 Stephanie Lozano Victoria Padilla Manuel Lee Avila Mario Gil Gladys Maestre Kesheng Wang Chun Xu <i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
description	Genetic variants in the apolipoprotein E (<i>APOE</i>) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the <i>APOE</i> gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene’s associations with cholesterol level and its related phenotypes. The <i>APOE</i> gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N = 62). Questionnaires on demographics, medical history, and blood/saliva samples were collected and <i>APOE</i> genotypes were performed. We observed allele frequencies of the <i>APOE</i> ε3 (96.7%), ε4 (22.6%) and ε2 (6.8%) alleles, respectively. Multivariable logistic regression revealed a significant association between the <i>APOE</i> ε4 allele and hypercholesteremia (<i>p</i> = 1.8 × 10<sup>−4</sup>) in our studied Hispanic population. We prove for the first time, that the APOE ε4 allele increases the risk for hypercholesterol in Hispanics. Further research is needed to confirm and supports our current findings.
format	article
author	Stephanie Lozano Victoria Padilla Manuel Lee Avila Mario Gil Gladys Maestre Kesheng Wang Chun Xu
author_facet	Stephanie Lozano Victoria Padilla Manuel Lee Avila Mario Gil Gladys Maestre Kesheng Wang Chun Xu
author_sort	Stephanie Lozano
title	<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
title_short	<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
title_full	<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
title_fullStr	<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
title_full_unstemmed	<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population
title_sort	<i>apoe</i> gene associated with cholesterol-related traits in the hispanic population
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/59aca231e2f84d1abd050d5ec9f9ebcc
work_keys_str_mv	AT stephanielozano iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation AT victoriapadilla iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation AT manuelleeavila iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation AT mariogil iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation AT gladysmaestre iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation AT keshengwang iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation AT chunxu iapoeigeneassociatedwithcholesterolrelatedtraitsinthehispanicpopulation
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<i>APOE</i> Gene Associated with Cholesterol-Related Traits in the Hispanic Population

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