Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?

Introduction: Septal mass reduction is beneficial for hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular outflow (LVOT) gradient and symptoms, with surgical myectomy or alcohol septal ablation (ASA) currently recommended in selected patients. Radiofrequency (RF) abl...

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Autores principales: Qiang Liu, Hangyuan Qiu, Ruhong Jiang, Xiaomei Tang, Wenpu Guo, Kuangshi Zhou, Qiufan Chen, Yaxun Sun, Lu Yu, Shiquan Chen, Pei Zhang, Xia Sheng, Jun Zhu, Jianwei Lin, Hui Cheng, Yunhe Wang, Bei Wang, Chan Yu, Yankai Mao, Juhong Zhang, Zuwen Zhang, Paul C. Zei, Guosheng Fu, Chenyang Jiang
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Publicado: Frontiers Media S.A. 2021
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spelling oai:doaj.org-article:59afec25611f44e2a9f56e0e124a4b012021-11-16T05:21:03ZSelective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?2297-055X10.3389/fcvm.2021.743044https://doaj.org/article/59afec25611f44e2a9f56e0e124a4b012021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.743044/fullhttps://doaj.org/toc/2297-055XIntroduction: Septal mass reduction is beneficial for hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular outflow (LVOT) gradient and symptoms, with surgical myectomy or alcohol septal ablation (ASA) currently recommended in selected patients. Radiofrequency (RF) ablation of hypertrophied septum has been published as a novel method to alleviate LVOT obstruction in small populations. This study aims to investigate factors influencing clinical outcomes of radiofrequency septum ablation.Methods and Results: In this study, 20 patients with HOCM who underwent endocardial ablation were included. Echocardiography and cardiac MRI (CMR) data was collected and analyzed pre- and (or) post- procedure. Nineteen patients underwent ablation successfully, while ablation was aborted in one patient with prior RBBB due to transient complete atrioventricular block (AVB). After 6 months of follow-up, NYHA heart functional class improved from III (2 - 3) to II (1 - 2) (p < 0.001), and resting LVOT gradient was significantly reduced (87.6 ± 29.5 mmHg vs. 48.1 ± 29.7, p < 0.001). LVOT gradient reduction was significantly higher in patients with limited basal septal hypertrophy (60.9 ± 8.3 vs. 27.9 ± 7.1, p = 0.01), shorter anterior mitral leaflet (56.1 ± 6.4 vs. 20.4 ± 5.0, p < 0.01), and normally positioned papillary muscle (36.9 ± 7.1 vs. 75.0 ± 6.3, p < 0.05).Conclusions: Endocardial septal ablation appears to be a safe and effective procedure for alleviating LVOT gradient in patients with HOCM, especially in those with limited basal septal hypertrophy, shorter anterior mitral leaflet, and normal positioned papillary muscle.Qiang LiuHangyuan QiuRuhong JiangXiaomei TangWenpu GuoKuangshi ZhouQiufan ChenYaxun SunLu YuShiquan ChenPei ZhangXia ShengJun ZhuJianwei LinHui ChengYunhe WangBei WangChan YuYankai MaoJuhong ZhangZuwen ZhangPaul C. ZeiGuosheng FuChenyang JiangFrontiers Media S.A.articlehypertrophic obstructive cardiomyopathyradiofrequency septal ablationanterior mitral leafletpapillary muscle displacementmid-septal hypertrophyDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution DOAJ
collection DOAJ
language EN
topic hypertrophic obstructive cardiomyopathy
radiofrequency septal ablation
anterior mitral leaflet
papillary muscle displacement
mid-septal hypertrophy
Diseases of the circulatory (Cardiovascular) system
RC666-701
spellingShingle hypertrophic obstructive cardiomyopathy
radiofrequency septal ablation
anterior mitral leaflet
papillary muscle displacement
mid-septal hypertrophy
Diseases of the circulatory (Cardiovascular) system
RC666-701
Qiang Liu
Hangyuan Qiu
Ruhong Jiang
Xiaomei Tang
Wenpu Guo
Kuangshi Zhou
Qiufan Chen
Yaxun Sun
Lu Yu
Shiquan Chen
Pei Zhang
Xia Sheng
Jun Zhu
Jianwei Lin
Hui Cheng
Yunhe Wang
Bei Wang
Chan Yu
Yankai Mao
Juhong Zhang
Zuwen Zhang
Paul C. Zei
Guosheng Fu
Chenyang Jiang
Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?
description Introduction: Septal mass reduction is beneficial for hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular outflow (LVOT) gradient and symptoms, with surgical myectomy or alcohol septal ablation (ASA) currently recommended in selected patients. Radiofrequency (RF) ablation of hypertrophied septum has been published as a novel method to alleviate LVOT obstruction in small populations. This study aims to investigate factors influencing clinical outcomes of radiofrequency septum ablation.Methods and Results: In this study, 20 patients with HOCM who underwent endocardial ablation were included. Echocardiography and cardiac MRI (CMR) data was collected and analyzed pre- and (or) post- procedure. Nineteen patients underwent ablation successfully, while ablation was aborted in one patient with prior RBBB due to transient complete atrioventricular block (AVB). After 6 months of follow-up, NYHA heart functional class improved from III (2 - 3) to II (1 - 2) (p < 0.001), and resting LVOT gradient was significantly reduced (87.6 ± 29.5 mmHg vs. 48.1 ± 29.7, p < 0.001). LVOT gradient reduction was significantly higher in patients with limited basal septal hypertrophy (60.9 ± 8.3 vs. 27.9 ± 7.1, p = 0.01), shorter anterior mitral leaflet (56.1 ± 6.4 vs. 20.4 ± 5.0, p < 0.01), and normally positioned papillary muscle (36.9 ± 7.1 vs. 75.0 ± 6.3, p < 0.05).Conclusions: Endocardial septal ablation appears to be a safe and effective procedure for alleviating LVOT gradient in patients with HOCM, especially in those with limited basal septal hypertrophy, shorter anterior mitral leaflet, and normal positioned papillary muscle.
format article
author Qiang Liu
Hangyuan Qiu
Ruhong Jiang
Xiaomei Tang
Wenpu Guo
Kuangshi Zhou
Qiufan Chen
Yaxun Sun
Lu Yu
Shiquan Chen
Pei Zhang
Xia Sheng
Jun Zhu
Jianwei Lin
Hui Cheng
Yunhe Wang
Bei Wang
Chan Yu
Yankai Mao
Juhong Zhang
Zuwen Zhang
Paul C. Zei
Guosheng Fu
Chenyang Jiang
author_facet Qiang Liu
Hangyuan Qiu
Ruhong Jiang
Xiaomei Tang
Wenpu Guo
Kuangshi Zhou
Qiufan Chen
Yaxun Sun
Lu Yu
Shiquan Chen
Pei Zhang
Xia Sheng
Jun Zhu
Jianwei Lin
Hui Cheng
Yunhe Wang
Bei Wang
Chan Yu
Yankai Mao
Juhong Zhang
Zuwen Zhang
Paul C. Zei
Guosheng Fu
Chenyang Jiang
author_sort Qiang Liu
title Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?
title_short Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?
title_full Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?
title_fullStr Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?
title_full_unstemmed Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?
title_sort selective interventricular septal radiofrequency ablation in patients with hypertrophic obstructive cardiomyopathy: who can benefit?
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/59afec25611f44e2a9f56e0e124a4b01
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