Self-assembly and regulation of protein cages from pre-organised coiled-coil modules

Coiled-coil protein origami is a strategy for the de novo design of polypeptide nanostructures based on coiled-coil dimer forming peptides, where a single chain protein folds into a polyhedral cage. Here, the authors design a single-chain triangular bipyramid and also demonstrate that the bipyramid...

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Autores principales:	Fabio Lapenta, Jana Aupič, Marco Vezzoli, Žiga Strmšek, Stefano Da Vela, Dmitri I. Svergun, José María Carazo, Roberto Melero, Roman Jerala
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59b662ee2eb34c1b9ef2ffa7c77f0b87
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spelling	oai:doaj.org-article:59b662ee2eb34c1b9ef2ffa7c77f0b872021-12-02T12:09:31ZSelf-assembly and regulation of protein cages from pre-organised coiled-coil modules10.1038/s41467-021-21184-62041-1723https://doaj.org/article/59b662ee2eb34c1b9ef2ffa7c77f0b872021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21184-6https://doaj.org/toc/2041-1723Coiled-coil protein origami is a strategy for the de novo design of polypeptide nanostructures based on coiled-coil dimer forming peptides, where a single chain protein folds into a polyhedral cage. Here, the authors design a single-chain triangular bipyramid and also demonstrate that the bipyramid can be self-assembled as a heterodimeric complex, comprising pre-defined subunits.Fabio LapentaJana AupičMarco VezzoliŽiga StrmšekStefano Da VelaDmitri I. SvergunJosé María CarazoRoberto MeleroRoman JeralaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fabio Lapenta Jana Aupič Marco Vezzoli Žiga Strmšek Stefano Da Vela Dmitri I. Svergun José María Carazo Roberto Melero Roman Jerala Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
description	Coiled-coil protein origami is a strategy for the de novo design of polypeptide nanostructures based on coiled-coil dimer forming peptides, where a single chain protein folds into a polyhedral cage. Here, the authors design a single-chain triangular bipyramid and also demonstrate that the bipyramid can be self-assembled as a heterodimeric complex, comprising pre-defined subunits.
format	article
author	Fabio Lapenta Jana Aupič Marco Vezzoli Žiga Strmšek Stefano Da Vela Dmitri I. Svergun José María Carazo Roberto Melero Roman Jerala
author_facet	Fabio Lapenta Jana Aupič Marco Vezzoli Žiga Strmšek Stefano Da Vela Dmitri I. Svergun José María Carazo Roberto Melero Roman Jerala
author_sort	Fabio Lapenta
title	Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
title_short	Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
title_full	Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
title_fullStr	Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
title_full_unstemmed	Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
title_sort	self-assembly and regulation of protein cages from pre-organised coiled-coil modules
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59b662ee2eb34c1b9ef2ffa7c77f0b87
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Self-assembly and regulation of protein cages from pre-organised coiled-coil modules

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