T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration

In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.

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Autores principales:	Damien Garbett, Anjali Bisaria, Changsong Yang, Dannielle G. McCarthy, Arnold Hayer, W. E. Moerner, Tatyana M. Svitkina, Tobias Meyer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59bc2c586f4e4738a09ac0f4b0640fca
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spelling	oai:doaj.org-article:59bc2c586f4e4738a09ac0f4b0640fca2021-12-02T18:14:31ZT-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration10.1038/s41467-020-18586-32041-1723https://doaj.org/article/59bc2c586f4e4738a09ac0f4b0640fca2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18586-3https://doaj.org/toc/2041-1723In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.Damien GarbettAnjali BisariaChangsong YangDannielle G. McCarthyArnold HayerW. E. MoernerTatyana M. SvitkinaTobias MeyerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Damien Garbett Anjali Bisaria Changsong Yang Dannielle G. McCarthy Arnold Hayer W. E. Moerner Tatyana M. Svitkina Tobias Meyer T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
description	In vivo, cells migrate across a diverse landscape of extracellular matrix containing gaps which present a challenge for cells to protrude across. Here, the authors show that T-Plastin strengthens protrusive actin networks to promote protrusion, extracellular matrix gap-bridging, and cell migration.
format	article
author	Damien Garbett Anjali Bisaria Changsong Yang Dannielle G. McCarthy Arnold Hayer W. E. Moerner Tatyana M. Svitkina Tobias Meyer
author_facet	Damien Garbett Anjali Bisaria Changsong Yang Dannielle G. McCarthy Arnold Hayer W. E. Moerner Tatyana M. Svitkina Tobias Meyer
author_sort	Damien Garbett
title	T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
title_short	T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
title_full	T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
title_fullStr	T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
title_full_unstemmed	T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
title_sort	t-plastin reinforces membrane protrusions to bridge matrix gaps during cell migration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/59bc2c586f4e4738a09ac0f4b0640fca
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T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration

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