Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function

Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2% of the general population, which can be accompanied by psoriatic arthritis (PsA). The condition has been associated with an increased cardiovascular burden. Hypercoagulability is a potential underl...

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Autores principales:	Maria J. E. Visser, Chantelle Venter, Timothy J. Roberts, Gareth Tarr, Etheresia Pretorius
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59bd04e9ace6497fbe114a63cc1e06d1
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spelling	oai:doaj.org-article:59bd04e9ace6497fbe114a63cc1e06d12021-12-02T18:02:49ZPsoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function10.1038/s41598-021-90684-82045-2322https://doaj.org/article/59bd04e9ace6497fbe114a63cc1e06d12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90684-8https://doaj.org/toc/2045-2322Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2% of the general population, which can be accompanied by psoriatic arthritis (PsA). The condition has been associated with an increased cardiovascular burden. Hypercoagulability is a potential underlying mechanism that may contribute to the increased risk of major cardiovascular events in psoriatic individuals. Whole blood samples were collected from 20 PsA patients and 20 healthy individuals. The concentrations of inflammatory molecules (C-reactive protein, serum amyloid A, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and soluble P-selectin) were determined by enzyme-linked immunosorbent assays. In addition, clotting efficiency was evaluated by thromboelastography. The fibrin network architecture was also assessed by scanning electron microscopy. Elevated levels of circulating inflammatory molecules were significantly associated with the presence of psoriatic disease. Furthermore, an increased tendency towards thrombus formation was significantly predictive of disease presence. Scanning electron microscopy revealed that fibrin clots were denser in psoriatic individuals, compared to healthy controls, with an increased fibrin fibre diameter associated with psoriatic disease. Our results add to the accumulating evidence of the systemic nature of psoriasis and the subsequent risk of cardiovascular comorbidities, potentially due to an acquired hypercoagulability. We suggest that haemostatic function should be monitored carefully in psoriatic patients that present with severe disease, due to the pre-eminent risk of developing thrombotic complications.Maria J. E. VisserChantelle VenterTimothy J. RobertsGareth TarrEtheresia PretoriusNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria J. E. Visser Chantelle Venter Timothy J. Roberts Gareth Tarr Etheresia Pretorius Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
description	Abstract Psoriasis is a chronic, immune-mediated inflammatory skin disease, affecting approximately 2% of the general population, which can be accompanied by psoriatic arthritis (PsA). The condition has been associated with an increased cardiovascular burden. Hypercoagulability is a potential underlying mechanism that may contribute to the increased risk of major cardiovascular events in psoriatic individuals. Whole blood samples were collected from 20 PsA patients and 20 healthy individuals. The concentrations of inflammatory molecules (C-reactive protein, serum amyloid A, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and soluble P-selectin) were determined by enzyme-linked immunosorbent assays. In addition, clotting efficiency was evaluated by thromboelastography. The fibrin network architecture was also assessed by scanning electron microscopy. Elevated levels of circulating inflammatory molecules were significantly associated with the presence of psoriatic disease. Furthermore, an increased tendency towards thrombus formation was significantly predictive of disease presence. Scanning electron microscopy revealed that fibrin clots were denser in psoriatic individuals, compared to healthy controls, with an increased fibrin fibre diameter associated with psoriatic disease. Our results add to the accumulating evidence of the systemic nature of psoriasis and the subsequent risk of cardiovascular comorbidities, potentially due to an acquired hypercoagulability. We suggest that haemostatic function should be monitored carefully in psoriatic patients that present with severe disease, due to the pre-eminent risk of developing thrombotic complications.
format	article
author	Maria J. E. Visser Chantelle Venter Timothy J. Roberts Gareth Tarr Etheresia Pretorius
author_facet	Maria J. E. Visser Chantelle Venter Timothy J. Roberts Gareth Tarr Etheresia Pretorius
author_sort	Maria J. E. Visser
title	Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
title_short	Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
title_full	Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
title_fullStr	Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
title_full_unstemmed	Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
title_sort	psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59bd04e9ace6497fbe114a63cc1e06d1
work_keys_str_mv	AT mariajevisser psoriaticdiseaseisassociatedwithsystemicinflammationendothelialactivationandalteredhaemostaticfunction AT chantelleventer psoriaticdiseaseisassociatedwithsystemicinflammationendothelialactivationandalteredhaemostaticfunction AT timothyjroberts psoriaticdiseaseisassociatedwithsystemicinflammationendothelialactivationandalteredhaemostaticfunction AT garethtarr psoriaticdiseaseisassociatedwithsystemicinflammationendothelialactivationandalteredhaemostaticfunction AT etheresiapretorius psoriaticdiseaseisassociatedwithsystemicinflammationendothelialactivationandalteredhaemostaticfunction
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Psoriatic disease is associated with systemic inflammation, endothelial activation, and altered haemostatic function

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