Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy

Ahmad AlAraj,1,2 Ahmad AlAmeer,1,3 Samar Al-Swailem1 1Anterior Segment Division, Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi Arabia; 3Ophthalmology Division, Sur...

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Autores principales:	AlAraj A, AlAmeer A, Al-Swailem S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	macular corneal dystrophy keratoplasty lamellar keratoplasty penetrating keratoplasty Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/59be9288eaeb4785b5a67880c3ee396e
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spelling	oai:doaj.org-article:59be9288eaeb4785b5a67880c3ee396e2021-12-02T16:17:58ZMedium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy1177-5483https://doaj.org/article/59be9288eaeb4785b5a67880c3ee396e2021-07-01T00:00:00Zhttps://www.dovepress.com/medium-term-clinical-outcomes-of-deep-anterior-lamellar-keratoplasty-v-peer-reviewed-fulltext-article-OPTHhttps://doaj.org/toc/1177-5483Ahmad AlAraj,1,2 Ahmad AlAmeer,1,3 Samar Al-Swailem1 1Anterior Segment Division, Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi Arabia; 3Ophthalmology Division, Surgery Department, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi ArabiaCorrespondence: Samar Al-SwailemAnterior Segment Division, Department of Ophthalmology, King Khaled Eye Specialist Hospital, P.O. Box 7191, Riyadh, 11462, Kingdom of Saudi ArabiaTel +966-11-482-1234 ext.1152Email angelofsa@yahoo.comPurpose: To compare the postoperative outcomes of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) for macular corneal dystrophy (MCD).Design: Single-center, retrospective, interventional case series.Methods: A chart review was performed of 100 patients (157 eyes) who underwent primary DALK (DALK group) and PKP (PKP group) for histopathologically confirmed MCD for whom at least 12 months of follow-up were available. Between-group comparisons were performed of visual acuity (VA), graft survival, and postoperative complications.Results: There were 22 eyes in the DALK group and 135 in the PKP group. Postoperative best-corrected visual acuity (BCVA) of 20/40 or better was achieved in 90.9% of the DALK group and 76.3% of the PKP group (P=0.12). At last visit, graft survival was 95.5% (21 eyes) and 91.1% (123 eyes) in DALK and PKP groups, respectively (P=0.69, Log rank test). Corneal graft rejection episodes occurred in 1 (4.5%) DALK graft and 19 (14.1%) PKP grafts. Five of the 19 graft rejections in the PKP group were irreversible. Microbial keratitis and cataract occurred in 6 (4.5%) and 15 (11.1%) PKP eyes. One (4.5%) eye in the DALK group had cataract and none of the DALK cases developed microbial keratitis. Clinically significant recurrence was observed in 4 (2.9%) PKP eyes and 1 (4.5%) DALK eye (P=0.69), respectively.Conclusion: DALK is a viable option for MCD without Descemet membrane involvement. DALK had comparable medium-term visual and survival outcomes to PKP. DALK has the advantage of lower open sky intraoperative complications and lower graft rejection episodes.Keywords: macular corneal dystrophy, keratoplasty, lamellar keratoplasty, penetrating keratoplastyAlAraj AAlAmeer AAl-Swailem SDove Medical Pressarticlemacular corneal dystrophykeratoplastylamellar keratoplastypenetrating keratoplastyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 3139-3145 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macular corneal dystrophy keratoplasty lamellar keratoplasty penetrating keratoplasty Ophthalmology RE1-994
spellingShingle	macular corneal dystrophy keratoplasty lamellar keratoplasty penetrating keratoplasty Ophthalmology RE1-994 AlAraj A AlAmeer A Al-Swailem S Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy
description	Ahmad AlAraj,1,2 Ahmad AlAmeer,1,3 Samar Al-Swailem1 1Anterior Segment Division, Department of Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia; 2Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi Arabia; 3Ophthalmology Division, Surgery Department, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi ArabiaCorrespondence: Samar Al-SwailemAnterior Segment Division, Department of Ophthalmology, King Khaled Eye Specialist Hospital, P.O. Box 7191, Riyadh, 11462, Kingdom of Saudi ArabiaTel +966-11-482-1234 ext.1152Email angelofsa@yahoo.comPurpose: To compare the postoperative outcomes of deep anterior lamellar keratoplasty (DALK) and penetrating keratoplasty (PKP) for macular corneal dystrophy (MCD).Design: Single-center, retrospective, interventional case series.Methods: A chart review was performed of 100 patients (157 eyes) who underwent primary DALK (DALK group) and PKP (PKP group) for histopathologically confirmed MCD for whom at least 12 months of follow-up were available. Between-group comparisons were performed of visual acuity (VA), graft survival, and postoperative complications.Results: There were 22 eyes in the DALK group and 135 in the PKP group. Postoperative best-corrected visual acuity (BCVA) of 20/40 or better was achieved in 90.9% of the DALK group and 76.3% of the PKP group (P=0.12). At last visit, graft survival was 95.5% (21 eyes) and 91.1% (123 eyes) in DALK and PKP groups, respectively (P=0.69, Log rank test). Corneal graft rejection episodes occurred in 1 (4.5%) DALK graft and 19 (14.1%) PKP grafts. Five of the 19 graft rejections in the PKP group were irreversible. Microbial keratitis and cataract occurred in 6 (4.5%) and 15 (11.1%) PKP eyes. One (4.5%) eye in the DALK group had cataract and none of the DALK cases developed microbial keratitis. Clinically significant recurrence was observed in 4 (2.9%) PKP eyes and 1 (4.5%) DALK eye (P=0.69), respectively.Conclusion: DALK is a viable option for MCD without Descemet membrane involvement. DALK had comparable medium-term visual and survival outcomes to PKP. DALK has the advantage of lower open sky intraoperative complications and lower graft rejection episodes.Keywords: macular corneal dystrophy, keratoplasty, lamellar keratoplasty, penetrating keratoplasty
format	article
author	AlAraj A AlAmeer A Al-Swailem S
author_facet	AlAraj A AlAmeer A Al-Swailem S
author_sort	AlAraj A
title	Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy
title_short	Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy
title_full	Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy
title_fullStr	Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy
title_full_unstemmed	Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy
title_sort	medium-term clinical outcomes of deep anterior lamellar keratoplasty versus penetrating keratoplasty for macular corneal dystrophy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/59be9288eaeb4785b5a67880c3ee396e
work_keys_str_mv	AT alaraja mediumtermclinicaloutcomesofdeepanteriorlamellarkeratoplastyversuspenetratingkeratoplastyformacularcornealdystrophy AT alameera mediumtermclinicaloutcomesofdeepanteriorlamellarkeratoplastyversuspenetratingkeratoplastyformacularcornealdystrophy AT alswailems mediumtermclinicaloutcomesofdeepanteriorlamellarkeratoplastyversuspenetratingkeratoplastyformacularcornealdystrophy
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Medium-Term Clinical Outcomes of Deep Anterior Lamellar Keratoplasty versus Penetrating Keratoplasty for Macular Corneal Dystrophy

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