Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis

Abstract Blood pressure variability (BPV) is associated with higher cardiovascular morbidity risks; however, its association with cognitive decline remains unclear. We investigated whether higher BPV is associated with faster declines in cognitive function in ischemic stroke (IS) patients. Cognitive...

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Autores principales:	Yerim Kim, Jae-Sung Lim, Mi Sun Oh, Kyung-Ho Yu, Ji Sung Lee, Jong-Ho Park, Yong-Jae Kim, Joung-Ho Rha, Yang-Ha Hwang, Sung Hyuk Heo, Seong Hwan Ahn, Ju-Hun Lee, Sun U. Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59bf9c0096e44bc5b62563fa0fd3fc68
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spelling	oai:doaj.org-article:59bf9c0096e44bc5b62563fa0fd3fc682021-12-02T15:54:09ZBlood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis10.1038/s41598-021-83945-z2045-2322https://doaj.org/article/59bf9c0096e44bc5b62563fa0fd3fc682021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83945-zhttps://doaj.org/toc/2045-2322Abstract Blood pressure variability (BPV) is associated with higher cardiovascular morbidity risks; however, its association with cognitive decline remains unclear. We investigated whether higher BPV is associated with faster declines in cognitive function in ischemic stroke (IS) patients. Cognitive function was evaluated between April 2010 and August 2015 using the Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment in 1,240 Korean PICASSO participants. Patients for whom baseline and follow-up cognitive test results and at least five valid BP readings were available were included. A restricted maximum likelihood–based Mixed Model for Repeated Measures was used to compare changes in cognitive function over time. Among a total of 746 participants (64.6 ± 10.8 years; 35.9% female). Baseline mean-MMSE score was 24.9 ± 4.7. The median number of BP readings was 11. During a mean follow-up of 2.6 years, mean baseline and last follow-up MMSE scores were 25.4 ± 4.8 vs. 27.8 ± 4.4 (the lowest BPV group) and 23.9 ± 5.2 vs. 23.2 ± 5.9 (the highest BPV group). After adjusting for multiple variables, higher BPV was independently associated with faster cognitive decline over time. However, no significant intergroup difference in cognitive changes associated with mean systolic BP was observed. Further research is needed to elucidate how BPV might affect cognitive function.Yerim KimJae-Sung LimMi Sun OhKyung-Ho YuJi Sung LeeJong-Ho ParkYong-Jae KimJoung-Ho RhaYang-Ha HwangSung Hyuk HeoSeong Hwan AhnJu-Hun LeeSun U. KwonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yerim Kim Jae-Sung Lim Mi Sun Oh Kyung-Ho Yu Ji Sung Lee Jong-Ho Park Yong-Jae Kim Joung-Ho Rha Yang-Ha Hwang Sung Hyuk Heo Seong Hwan Ahn Ju-Hun Lee Sun U. Kwon Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
description	Abstract Blood pressure variability (BPV) is associated with higher cardiovascular morbidity risks; however, its association with cognitive decline remains unclear. We investigated whether higher BPV is associated with faster declines in cognitive function in ischemic stroke (IS) patients. Cognitive function was evaluated between April 2010 and August 2015 using the Mini-mental State Examination (MMSE) and Montreal Cognitive Assessment in 1,240 Korean PICASSO participants. Patients for whom baseline and follow-up cognitive test results and at least five valid BP readings were available were included. A restricted maximum likelihood–based Mixed Model for Repeated Measures was used to compare changes in cognitive function over time. Among a total of 746 participants (64.6 ± 10.8 years; 35.9% female). Baseline mean-MMSE score was 24.9 ± 4.7. The median number of BP readings was 11. During a mean follow-up of 2.6 years, mean baseline and last follow-up MMSE scores were 25.4 ± 4.8 vs. 27.8 ± 4.4 (the lowest BPV group) and 23.9 ± 5.2 vs. 23.2 ± 5.9 (the highest BPV group). After adjusting for multiple variables, higher BPV was independently associated with faster cognitive decline over time. However, no significant intergroup difference in cognitive changes associated with mean systolic BP was observed. Further research is needed to elucidate how BPV might affect cognitive function.
format	article
author	Yerim Kim Jae-Sung Lim Mi Sun Oh Kyung-Ho Yu Ji Sung Lee Jong-Ho Park Yong-Jae Kim Joung-Ho Rha Yang-Ha Hwang Sung Hyuk Heo Seong Hwan Ahn Ju-Hun Lee Sun U. Kwon
author_facet	Yerim Kim Jae-Sung Lim Mi Sun Oh Kyung-Ho Yu Ji Sung Lee Jong-Ho Park Yong-Jae Kim Joung-Ho Rha Yang-Ha Hwang Sung Hyuk Heo Seong Hwan Ahn Ju-Hun Lee Sun U. Kwon
author_sort	Yerim Kim
title	Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
title_short	Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
title_full	Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
title_fullStr	Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
title_full_unstemmed	Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis
title_sort	blood pressure variability is related to faster cognitive decline in ischemic stroke patients: picasso subanalysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59bf9c0096e44bc5b62563fa0fd3fc68
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Blood pressure variability is related to faster cognitive decline in ischemic stroke patients: PICASSO subanalysis

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