Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

PIWI protein contains arginine rich motifs that are post-translationally modified to symmetrically methylated arginine (sDMA) residues. Here the authors show that piRNA loading into Aub triggers sDMA modification which is recognized by Krimper to promote formation of Krimper-Aub-Ago3 complex for piR...

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Autores principales:	Xiawei Huang, Hongmiao Hu, Alexandre Webster, Fan Zou, Jiamu Du, Dinshaw J. Patel, Ravi Sachidanandam, Katalin Fejes Toth, Alexei A. Aravin, Sisi Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59c7195a03f14f1aacffded3ab5750b0
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spelling	oai:doaj.org-article:59c7195a03f14f1aacffded3ab5750b02021-12-02T14:34:05ZBinding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex10.1038/s41467-021-24351-x2041-1723https://doaj.org/article/59c7195a03f14f1aacffded3ab5750b02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24351-xhttps://doaj.org/toc/2041-1723PIWI protein contains arginine rich motifs that are post-translationally modified to symmetrically methylated arginine (sDMA) residues. Here the authors show that piRNA loading into Aub triggers sDMA modification which is recognized by Krimper to promote formation of Krimper-Aub-Ago3 complex for piRNA amplification in Drosophila.Xiawei HuangHongmiao HuAlexandre WebsterFan ZouJiamu DuDinshaw J. PatelRavi SachidanandamKatalin Fejes TothAlexei A. AravinSisi LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiawei Huang Hongmiao Hu Alexandre Webster Fan Zou Jiamu Du Dinshaw J. Patel Ravi Sachidanandam Katalin Fejes Toth Alexei A. Aravin Sisi Li Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
description	PIWI protein contains arginine rich motifs that are post-translationally modified to symmetrically methylated arginine (sDMA) residues. Here the authors show that piRNA loading into Aub triggers sDMA modification which is recognized by Krimper to promote formation of Krimper-Aub-Ago3 complex for piRNA amplification in Drosophila.
format	article
author	Xiawei Huang Hongmiao Hu Alexandre Webster Fan Zou Jiamu Du Dinshaw J. Patel Ravi Sachidanandam Katalin Fejes Toth Alexei A. Aravin Sisi Li
author_facet	Xiawei Huang Hongmiao Hu Alexandre Webster Fan Zou Jiamu Du Dinshaw J. Patel Ravi Sachidanandam Katalin Fejes Toth Alexei A. Aravin Sisi Li
author_sort	Xiawei Huang
title	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
title_short	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
title_full	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
title_fullStr	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
title_full_unstemmed	Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex
title_sort	binding of guide pirna triggers methylation of the unstructured n-terminal region of aub leading to assembly of the pirna amplification complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59c7195a03f14f1aacffded3ab5750b0
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Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex

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