Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole
Subramanian Madhusoodanan1, Payal Shah21St John’s Episcopal Hospital Far Rockaway, NY 11691, SUNY, Brooklyn NY, USA. 2SUNY Health Science Center, Brooklyn, NYAbstract: Psychosis of Alzheimer’s disease (AD) is characterized by delusions or hallucinations and may be associated with...
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Dove Medical Press
2008
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oai:doaj.org-article:59c72234c0a0492db3db2960ee8d3a502021-12-02T02:34:53ZManagement of psychosis in patients with Alzheimer’s disease: focus on aripiprazole1178-1998https://doaj.org/article/59c72234c0a0492db3db2960ee8d3a502008-09-01T00:00:00Zhttps://www.dovepress.com/management-of-psychosis-in-patients-with-alzheimerrsquos-disease-focus-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Subramanian Madhusoodanan1, Payal Shah21St John’s Episcopal Hospital Far Rockaway, NY 11691, SUNY, Brooklyn NY, USA. 2SUNY Health Science Center, Brooklyn, NYAbstract: Psychosis of Alzheimer’s disease (AD) is characterized by delusions or hallucinations and may be associated with agitation, negative symptoms or depression. There are no psychotropic medications that are approved by the US FDA for the treatment of psychosis of AD. However, atypical antipsychotics have been widely used and recommended by geriatric experts in the management of psychosis of AD in view of the modest efficacy and relative safety until FDA warnings were issued in 2005 and meta-analytic studies showed no significant difference to placebo. The FDA warnings on the cardiac, metabolic, cerebrovascular, and mortality risks have caused serious concerns for the use of atypical antipsychotic agents in elderly patients with dementia. Only a few studies have evaluated prospectively the effects of aripiprazole in psychosis associated with AD. These studies show improvement in the symptoms of psychosis associated with AD with aripiprazole. The safety and tolerability profile of aripiprazole suggests a low potential for negative impact on dementia and overall patient health. Further studies comparing the efficacy and tolerability of aripiprazole vs other atypical antipsychotics in dementia are needed.Keywords: treatment, Alzheimer’s dementia, psychosis, aripiprazoleSubramanian MadhusoodananPayal ShahDove Medical PressarticleTreatmentAlzheimer’s DementiaPsychosisAripiprazoleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 491-501 (2008) |
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Treatment Alzheimer’s Dementia Psychosis Aripiprazole Geriatrics RC952-954.6 |
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Treatment Alzheimer’s Dementia Psychosis Aripiprazole Geriatrics RC952-954.6 Subramanian Madhusoodanan Payal Shah Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
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Subramanian Madhusoodanan1, Payal Shah21St John’s Episcopal Hospital Far Rockaway, NY 11691, SUNY, Brooklyn NY, USA. 2SUNY Health Science Center, Brooklyn, NYAbstract: Psychosis of Alzheimer’s disease (AD) is characterized by delusions or hallucinations and may be associated with agitation, negative symptoms or depression. There are no psychotropic medications that are approved by the US FDA for the treatment of psychosis of AD. However, atypical antipsychotics have been widely used and recommended by geriatric experts in the management of psychosis of AD in view of the modest efficacy and relative safety until FDA warnings were issued in 2005 and meta-analytic studies showed no significant difference to placebo. The FDA warnings on the cardiac, metabolic, cerebrovascular, and mortality risks have caused serious concerns for the use of atypical antipsychotic agents in elderly patients with dementia. Only a few studies have evaluated prospectively the effects of aripiprazole in psychosis associated with AD. These studies show improvement in the symptoms of psychosis associated with AD with aripiprazole. The safety and tolerability profile of aripiprazole suggests a low potential for negative impact on dementia and overall patient health. Further studies comparing the efficacy and tolerability of aripiprazole vs other atypical antipsychotics in dementia are needed.Keywords: treatment, Alzheimer’s dementia, psychosis, aripiprazole |
| format |
article |
| author |
Subramanian Madhusoodanan Payal Shah |
| author_facet |
Subramanian Madhusoodanan Payal Shah |
| author_sort |
Subramanian Madhusoodanan |
| title |
Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_short |
Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_full |
Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_fullStr |
Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_full_unstemmed |
Management of psychosis in patients with Alzheimer’s disease: focus on aripiprazole |
| title_sort |
management of psychosis in patients with alzheimer’s disease: focus on aripiprazole |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/59c72234c0a0492db3db2960ee8d3a50 |
| work_keys_str_mv |
AT subramanianmadhusoodanan managementofpsychosisinpatientswithalzheimerrsquosdiseasefocusonaripiprazole AT payalshah managementofpsychosisinpatientswithalzheimerrsquosdiseasefocusonaripiprazole |
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