Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans

Shuhei Nakanishi, Masayasu Yoneda, Shusaku Maeda Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Aim: To evaluate the impact of glucose excursion (GE) and mean glucose concentration (MGC) on oxidative stress amo...

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Autores principales:	Nakanishi S, Yoneda M, Maeda S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/59c861a0eecc419dbcc9cefdaec6b974
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spelling	oai:doaj.org-article:59c861a0eecc419dbcc9cefdaec6b9742021-12-02T01:10:17ZImpact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans1178-7007https://doaj.org/article/59c861a0eecc419dbcc9cefdaec6b9742013-11-01T00:00:00Zhttp://www.dovepress.com/impact-of-glucose-excursion-and-mean-glucose-concentration-in-oral-glu-a15060https://doaj.org/toc/1178-7007Shuhei Nakanishi, Masayasu Yoneda, Shusaku Maeda Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Aim: To evaluate the impact of glucose excursion (GE) and mean glucose concentration (MGC) on oxidative stress among persons with or without diabetes. Materials and methods: We examined 775 Japanese Americans who had normal glucose tolerance (NGT), impaired glucose tolerance, or diabetes according to the 75 g oral glucose-tolerance test, using fasting, 1-hour, and 2-hour glucose data. We calculated GE by subtracting the minimum from the maximum glucose level among three points and calculated MGC using these measurements. We investigated the relationship between GE or MGC and urinary isoprostane as a marker of oxidative stress. Results: According to tertiles of GE or MGC, GE was associated with isoprostane levels among subjects with NGT as well as those with diabetes (P=0.004 and 0.033 for trend, respectively). However, MGC was associated with isoprostane only among NGT subjects (P=0.001 for trend). Association between GE and isoprostane was significant when adjustment was made for age, sex, smoking status, body mass index, C-reactive protein, glucose tolerance status, and homeostatic model assessment (P=0.029), but the association with MGC was not significant. Conclusion: Our results suggest the possibility that GE might result in oxidative stress, and the relationship is stronger than that for MGC. Keywords: glucose excursion, glucose-tolerance test, oxidative stressNakanishi SYoneda MMaeda SDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2013, Iss default, Pp 427-433 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Nakanishi S Yoneda M Maeda S Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans
description	Shuhei Nakanishi, Masayasu Yoneda, Shusaku Maeda Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan Aim: To evaluate the impact of glucose excursion (GE) and mean glucose concentration (MGC) on oxidative stress among persons with or without diabetes. Materials and methods: We examined 775 Japanese Americans who had normal glucose tolerance (NGT), impaired glucose tolerance, or diabetes according to the 75 g oral glucose-tolerance test, using fasting, 1-hour, and 2-hour glucose data. We calculated GE by subtracting the minimum from the maximum glucose level among three points and calculated MGC using these measurements. We investigated the relationship between GE or MGC and urinary isoprostane as a marker of oxidative stress. Results: According to tertiles of GE or MGC, GE was associated with isoprostane levels among subjects with NGT as well as those with diabetes (P=0.004 and 0.033 for trend, respectively). However, MGC was associated with isoprostane only among NGT subjects (P=0.001 for trend). Association between GE and isoprostane was significant when adjustment was made for age, sex, smoking status, body mass index, C-reactive protein, glucose tolerance status, and homeostatic model assessment (P=0.029), but the association with MGC was not significant. Conclusion: Our results suggest the possibility that GE might result in oxidative stress, and the relationship is stronger than that for MGC. Keywords: glucose excursion, glucose-tolerance test, oxidative stress
format	article
author	Nakanishi S Yoneda M Maeda S
author_facet	Nakanishi S Yoneda M Maeda S
author_sort	Nakanishi S
title	Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans
title_short	Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans
title_full	Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans
title_fullStr	Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans
title_full_unstemmed	Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans
title_sort	impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among japanese americans
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/59c861a0eecc419dbcc9cefdaec6b974
work_keys_str_mv	AT nakanishis impactofglucoseexcursionandmeanglucoseconcentrationinoralglucosetolerancetestonoxidativestressamongjapaneseamericans AT yonedam impactofglucoseexcursionandmeanglucoseconcentrationinoralglucosetolerancetestonoxidativestressamongjapaneseamericans AT maedas impactofglucoseexcursionandmeanglucoseconcentrationinoralglucosetolerancetestonoxidativestressamongjapaneseamericans
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Impact of glucose excursion and mean glucose concentration in oral glucose-tolerance test on oxidative stress among Japanese Americans

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