Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract
Here, the authors report a multi-ethnic genome wide association meta-analysis of 12 studies from the International Cataract Genetics Consortium. They find six new loci associated with age-related nuclear cataract, in addition to replicating the association at CRYAA, and suggest a strong genetic link...
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Nature Portfolio
2020
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oai:doaj.org-article:59d197cca67a4e4b95995e668e03898d2021-12-02T16:18:00ZCommon variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract10.1038/s42003-020-01421-22399-3642https://doaj.org/article/59d197cca67a4e4b95995e668e03898d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01421-2https://doaj.org/toc/2399-3642Here, the authors report a multi-ethnic genome wide association meta-analysis of 12 studies from the International Cataract Genetics Consortium. They find six new loci associated with age-related nuclear cataract, in addition to replicating the association at CRYAA, and suggest a strong genetic link between age-related nuclear and congenital cataracts.Ekaterina Yonova-DoingWanting ZhaoRobert P. IgoChaolong WangPeriasamy SundaresanKristine E. LeeGyungah R. JunAlexessander Couto AlvesXiaoran ChaiAnita S. Y. ChanMei Chin LeeAllan FongAva G. TanChiea Chuen KhorEmily Y. ChewPirro G. HysiQiao FanJacqueline ChuaJaeyoon ChungJiemin LiaoJohanna M. ColijnKathryn P. BurdonLars G. FritscheMaria K. SwiftMaryam H. HilmyMiao Ling CheeMilly TedjaPieter W. M. BonnemaijerPreeti GuptaQueenie S. TanZheng LiEranga N. VithanaRavilla D. RavindranSoon-Phaik CheeYuan ShiWenting LiuXinyi SuXueling SimYang ShenYa Xing WangHengtong LiYih-Chung ThamYik Ying TeoTin AungKerrin S. SmallPaul MitchellJost B. JonasTien Yin WongAstrid E. FletcherCaroline C. W. KlaverBarbara E. K. KleinJie Jin WangSudha K. IyengarChristopher J. HammondChing-Yu ChengNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 3, Iss 1, Pp 1-8 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Ekaterina Yonova-Doing Wanting Zhao Robert P. Igo Chaolong Wang Periasamy Sundaresan Kristine E. Lee Gyungah R. Jun Alexessander Couto Alves Xiaoran Chai Anita S. Y. Chan Mei Chin Lee Allan Fong Ava G. Tan Chiea Chuen Khor Emily Y. Chew Pirro G. Hysi Qiao Fan Jacqueline Chua Jaeyoon Chung Jiemin Liao Johanna M. Colijn Kathryn P. Burdon Lars G. Fritsche Maria K. Swift Maryam H. Hilmy Miao Ling Chee Milly Tedja Pieter W. M. Bonnemaijer Preeti Gupta Queenie S. Tan Zheng Li Eranga N. Vithana Ravilla D. Ravindran Soon-Phaik Chee Yuan Shi Wenting Liu Xinyi Su Xueling Sim Yang Shen Ya Xing Wang Hengtong Li Yih-Chung Tham Yik Ying Teo Tin Aung Kerrin S. Small Paul Mitchell Jost B. Jonas Tien Yin Wong Astrid E. Fletcher Caroline C. W. Klaver Barbara E. K. Klein Jie Jin Wang Sudha K. Iyengar Christopher J. Hammond Ching-Yu Cheng Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract |
| description |
Here, the authors report a multi-ethnic genome wide association meta-analysis of 12 studies from the International Cataract Genetics Consortium. They find six new loci associated with age-related nuclear cataract, in addition to replicating the association at CRYAA, and suggest a strong genetic link between age-related nuclear and congenital cataracts. |
| format |
article |
| author |
Ekaterina Yonova-Doing Wanting Zhao Robert P. Igo Chaolong Wang Periasamy Sundaresan Kristine E. Lee Gyungah R. Jun Alexessander Couto Alves Xiaoran Chai Anita S. Y. Chan Mei Chin Lee Allan Fong Ava G. Tan Chiea Chuen Khor Emily Y. Chew Pirro G. Hysi Qiao Fan Jacqueline Chua Jaeyoon Chung Jiemin Liao Johanna M. Colijn Kathryn P. Burdon Lars G. Fritsche Maria K. Swift Maryam H. Hilmy Miao Ling Chee Milly Tedja Pieter W. M. Bonnemaijer Preeti Gupta Queenie S. Tan Zheng Li Eranga N. Vithana Ravilla D. Ravindran Soon-Phaik Chee Yuan Shi Wenting Liu Xinyi Su Xueling Sim Yang Shen Ya Xing Wang Hengtong Li Yih-Chung Tham Yik Ying Teo Tin Aung Kerrin S. Small Paul Mitchell Jost B. Jonas Tien Yin Wong Astrid E. Fletcher Caroline C. W. Klaver Barbara E. K. Klein Jie Jin Wang Sudha K. Iyengar Christopher J. Hammond Ching-Yu Cheng |
| author_facet |
Ekaterina Yonova-Doing Wanting Zhao Robert P. Igo Chaolong Wang Periasamy Sundaresan Kristine E. Lee Gyungah R. Jun Alexessander Couto Alves Xiaoran Chai Anita S. Y. Chan Mei Chin Lee Allan Fong Ava G. Tan Chiea Chuen Khor Emily Y. Chew Pirro G. Hysi Qiao Fan Jacqueline Chua Jaeyoon Chung Jiemin Liao Johanna M. Colijn Kathryn P. Burdon Lars G. Fritsche Maria K. Swift Maryam H. Hilmy Miao Ling Chee Milly Tedja Pieter W. M. Bonnemaijer Preeti Gupta Queenie S. Tan Zheng Li Eranga N. Vithana Ravilla D. Ravindran Soon-Phaik Chee Yuan Shi Wenting Liu Xinyi Su Xueling Sim Yang Shen Ya Xing Wang Hengtong Li Yih-Chung Tham Yik Ying Teo Tin Aung Kerrin S. Small Paul Mitchell Jost B. Jonas Tien Yin Wong Astrid E. Fletcher Caroline C. W. Klaver Barbara E. K. Klein Jie Jin Wang Sudha K. Iyengar Christopher J. Hammond Ching-Yu Cheng |
| author_sort |
Ekaterina Yonova-Doing |
| title |
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract |
| title_short |
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract |
| title_full |
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract |
| title_fullStr |
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract |
| title_full_unstemmed |
Common variants in SOX-2 and congenital cataract genes contribute to age-related nuclear cataract |
| title_sort |
common variants in sox-2 and congenital cataract genes contribute to age-related nuclear cataract |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/59d197cca67a4e4b95995e668e03898d |
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