Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus

Faranak Sharifi1, Amir Ziaee2, Abdolamir Feizi3, Nouraddin Mousavinasab1, Afagh Anjomshoaa1, Pooran Mokhtari41Zanjan Metabolic Diseases Research Center, Zanjan; 2Qazvin Metabolic Diseases Research Center, Qazvin; 3Zanjan University of Medical Sciences, Zanjan; 4Vali-e-asr Hospital, Zanjan, IranPurpo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sharifi F, Ziaee A, Feizy A, Mousavinasab, Anjomshoaa A, Mokhtari P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Gestational Diabetes Mellitus Ferritin Pregnancy outcome Diabetes mellitus CRP Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/59d2787b68f24acbb7f751ba11099b90
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:59d2787b68f24acbb7f751ba11099b90
record_format	dspace
spelling	oai:doaj.org-article:59d2787b68f24acbb7f751ba11099b902021-12-02T01:57:54ZSerum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus1178-7007https://doaj.org/article/59d2787b68f24acbb7f751ba11099b902010-12-01T00:00:00Zhttps://www.dovepress.com/serum-ferritin-concentration-in-gestational-diabetes-mellitus-and-risk-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Faranak Sharifi1, Amir Ziaee2, Abdolamir Feizi3, Nouraddin Mousavinasab1, Afagh Anjomshoaa1, Pooran Mokhtari41Zanjan Metabolic Diseases Research Center, Zanjan; 2Qazvin Metabolic Diseases Research Center, Qazvin; 3Zanjan University of Medical Sciences, Zanjan; 4Vali-e-asr Hospital, Zanjan, IranPurpose: To compare the serum ferritin concentrations of normal pregnant women with those having gestational diabetes mellitus (GDM) and to determine the possible role of ferritin in predicting pregnancy outcome and early development of postpartum glucose intolerance and diabetes mellitus.Method: This case-control study consisted of 128 pregnant women (64 women with GDM and 64 age-matched healthy pregnant women) seen at a university hospital in Zanjan, Iran. Anthropometric measurements were determined, and serum ferritin, C-reactive protein, insulin, glycosylated hemoglobin (HbA1c), and hemoglobin levels were measured. Pregnancy outcomes were recorded in all subjects. In the women with GDM, a diagnostic oral glucose tolerance test was performed eight weeks after delivery.Results: Women with GDM had a higher concentration of serum ferritin (112 ± 28.4 pmol/L in GDM versus 65 ± 16.9 pmol/L in controls, P<0.001). A positive correlation was found between serum ferritin level and mid-pregnancy fasting plasma glucose and HbAlc levels. Although women in the highest quartile of serum ferritin had a greater than two-fold increased risk of GDM, no significant correlation was found between ferritin levels and early postpartum oral glucose tolerance test results.Conclusions: Elevated serum ferritin concentrations in mid-pregnancy are associated with an increased risk of GDM independent of C-reactive protein and body mass index. Ferritin levels in GDM cannot be used as an indicator to predict subsequent glucose concentration in early postpartum oral glucose tolerance test.Keywords: gestational diabetes mellitus, ferritin, pregnancy outcome, diabetes mellitus, C-reactive proteinSharifi FZiaee AFeizy AMousavinasabAnjomshoaa AMokhtari PDove Medical PressarticleGestational Diabetes MellitusFerritinPregnancy outcomeDiabetes mellitusCRPSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 3, Pp 413-419 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Gestational Diabetes Mellitus Ferritin Pregnancy outcome Diabetes mellitus CRP Specialties of internal medicine RC581-951
spellingShingle	Gestational Diabetes Mellitus Ferritin Pregnancy outcome Diabetes mellitus CRP Specialties of internal medicine RC581-951 Sharifi F Ziaee A Feizy A Mousavinasab Anjomshoaa A Mokhtari P Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
description	Faranak Sharifi1, Amir Ziaee2, Abdolamir Feizi3, Nouraddin Mousavinasab1, Afagh Anjomshoaa1, Pooran Mokhtari41Zanjan Metabolic Diseases Research Center, Zanjan; 2Qazvin Metabolic Diseases Research Center, Qazvin; 3Zanjan University of Medical Sciences, Zanjan; 4Vali-e-asr Hospital, Zanjan, IranPurpose: To compare the serum ferritin concentrations of normal pregnant women with those having gestational diabetes mellitus (GDM) and to determine the possible role of ferritin in predicting pregnancy outcome and early development of postpartum glucose intolerance and diabetes mellitus.Method: This case-control study consisted of 128 pregnant women (64 women with GDM and 64 age-matched healthy pregnant women) seen at a university hospital in Zanjan, Iran. Anthropometric measurements were determined, and serum ferritin, C-reactive protein, insulin, glycosylated hemoglobin (HbA1c), and hemoglobin levels were measured. Pregnancy outcomes were recorded in all subjects. In the women with GDM, a diagnostic oral glucose tolerance test was performed eight weeks after delivery.Results: Women with GDM had a higher concentration of serum ferritin (112 ± 28.4 pmol/L in GDM versus 65 ± 16.9 pmol/L in controls, P<0.001). A positive correlation was found between serum ferritin level and mid-pregnancy fasting plasma glucose and HbAlc levels. Although women in the highest quartile of serum ferritin had a greater than two-fold increased risk of GDM, no significant correlation was found between ferritin levels and early postpartum oral glucose tolerance test results.Conclusions: Elevated serum ferritin concentrations in mid-pregnancy are associated with an increased risk of GDM independent of C-reactive protein and body mass index. Ferritin levels in GDM cannot be used as an indicator to predict subsequent glucose concentration in early postpartum oral glucose tolerance test.Keywords: gestational diabetes mellitus, ferritin, pregnancy outcome, diabetes mellitus, C-reactive protein
format	article
author	Sharifi F Ziaee A Feizy A Mousavinasab Anjomshoaa A Mokhtari P
author_facet	Sharifi F Ziaee A Feizy A Mousavinasab Anjomshoaa A Mokhtari P
author_sort	Sharifi F
title	Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
title_short	Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
title_full	Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
title_fullStr	Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
title_full_unstemmed	Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
title_sort	serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/59d2787b68f24acbb7f751ba11099b90
work_keys_str_mv	AT sharifif serumferritinconcentrationingestationaldiabetesmellitusandriskofsubsequentdevelopmentofearlypostpartumdiabetesmellitus AT ziaeea serumferritinconcentrationingestationaldiabetesmellitusandriskofsubsequentdevelopmentofearlypostpartumdiabetesmellitus AT feizya serumferritinconcentrationingestationaldiabetesmellitusandriskofsubsequentdevelopmentofearlypostpartumdiabetesmellitus AT mousavinasab serumferritinconcentrationingestationaldiabetesmellitusandriskofsubsequentdevelopmentofearlypostpartumdiabetesmellitus AT anjomshoaaa serumferritinconcentrationingestationaldiabetesmellitusandriskofsubsequentdevelopmentofearlypostpartumdiabetesmellitus AT mokhtarip serumferritinconcentrationingestationaldiabetesmellitusandriskofsubsequentdevelopmentofearlypostpartumdiabetesmellitus
_version_	1718402777315540992

Serum ferritin concentration in gestational diabetes mellitus and risk of subsequent development of early postpartum diabetes mellitus

Ejemplares similares