A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens

ABSTRACT A novel variant of the AAD(3″) class of aminoglycoside-modifying enzymes was discovered in fatal bovine respiratory disease-associated pathogens Pasteurella multocida and Histophilus somni. The aadA31 gene encodes a spectinomycin/streptomycin adenylyltransferase and was located in a variant...

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Autores principales:	Andrew Cameron, Cassidy L. Klima, Reuben Ha, Robert J. Gruninger, Rahat Zaheer, Tim A. McAllister
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	Histophilus somni Mannheimia haemolytica Pasteurella multocida aminoglycoside-modifying enzymes aminoglycosides antibiotic resistance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/59d59c9c6bd64d8ea54a1d579196cc5a
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spelling	oai:doaj.org-article:59d59c9c6bd64d8ea54a1d579196cc5a2021-11-15T15:22:02ZA Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens10.1128/mSphere.00568-172379-5042https://doaj.org/article/59d59c9c6bd64d8ea54a1d579196cc5a2018-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00568-17https://doaj.org/toc/2379-5042ABSTRACT A novel variant of the AAD(3″) class of aminoglycoside-modifying enzymes was discovered in fatal bovine respiratory disease-associated pathogens Pasteurella multocida and Histophilus somni. The aadA31 gene encodes a spectinomycin/streptomycin adenylyltransferase and was located in a variant of the integrative and conjugative element ICEMh1, a mobile genetic element transmissible among members of the family Pasteurellaceae. The gene was also detected in Mannheimia haemolytica from a case of porcine pneumonia and in Moraxella bovoculi from a case of keratoconjunctivitis. IMPORTANCE Aminoglycosides are important antimicrobials used worldwide for prophylaxis and/or therapy in multiple production animal species. The emergence of new resistance genes jeopardizes current pathogen detection and treatment methods. The risk of resistance gene transfer to other animal and human pathogens is elevated when resistance genes are carried by mobile genetic elements. This study identified a new variant of a spectinomycin/streptomycin resistance gene harbored in a self-transmissible mobile element. The gene was also present in four different bovine pathogen species.Andrew CameronCassidy L. KlimaReuben HaRobert J. GruningerRahat ZaheerTim A. McAllisterAmerican Society for MicrobiologyarticleHistophilus somniMannheimia haemolyticaPasteurella multocidaaminoglycoside-modifying enzymesaminoglycosidesantibiotic resistanceMicrobiologyQR1-502ENmSphere, Vol 3, Iss 1 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Histophilus somni Mannheimia haemolytica Pasteurella multocida aminoglycoside-modifying enzymes aminoglycosides antibiotic resistance Microbiology QR1-502
spellingShingle	Histophilus somni Mannheimia haemolytica Pasteurella multocida aminoglycoside-modifying enzymes aminoglycosides antibiotic resistance Microbiology QR1-502 Andrew Cameron Cassidy L. Klima Reuben Ha Robert J. Gruninger Rahat Zaheer Tim A. McAllister A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens
description	ABSTRACT A novel variant of the AAD(3″) class of aminoglycoside-modifying enzymes was discovered in fatal bovine respiratory disease-associated pathogens Pasteurella multocida and Histophilus somni. The aadA31 gene encodes a spectinomycin/streptomycin adenylyltransferase and was located in a variant of the integrative and conjugative element ICEMh1, a mobile genetic element transmissible among members of the family Pasteurellaceae. The gene was also detected in Mannheimia haemolytica from a case of porcine pneumonia and in Moraxella bovoculi from a case of keratoconjunctivitis. IMPORTANCE Aminoglycosides are important antimicrobials used worldwide for prophylaxis and/or therapy in multiple production animal species. The emergence of new resistance genes jeopardizes current pathogen detection and treatment methods. The risk of resistance gene transfer to other animal and human pathogens is elevated when resistance genes are carried by mobile genetic elements. This study identified a new variant of a spectinomycin/streptomycin resistance gene harbored in a self-transmissible mobile element. The gene was also present in four different bovine pathogen species.
format	article
author	Andrew Cameron Cassidy L. Klima Reuben Ha Robert J. Gruninger Rahat Zaheer Tim A. McAllister
author_facet	Andrew Cameron Cassidy L. Klima Reuben Ha Robert J. Gruninger Rahat Zaheer Tim A. McAllister
author_sort	Andrew Cameron
title	A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens
title_short	A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens
title_full	A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens
title_fullStr	A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens
title_full_unstemmed	A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens
title_sort	novel <italic toggle="yes">aada</italic> aminoglycoside resistance gene in bovine and porcine pathogens
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/59d59c9c6bd64d8ea54a1d579196cc5a
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A Novel <italic toggle="yes">aadA</italic> Aminoglycoside Resistance Gene in Bovine and Porcine Pathogens

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