Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia

Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia

Tomasz Pawelczyk,1 Bozena Szymanska,2 Marta Grancow-Grabka,3 Magdalena Kotlicka-Antczak,1 Agnieszka Pawelczyk1 1Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka, Lodz, Poland; 2Central Scientific Laboratory, Medical University of Lodz, Mazowiecka,...

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Autores principales: Pawelczyk T, Szymanska B, Grancow-Grabka M, Kotlicka-Antczak M, Pawelczyk A
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/59d7c1cbb96646d7b89dacac6e20fdbd
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spelling oai:doaj.org-article:59d7c1cbb96646d7b89dacac6e20fdbd2021-12-02T09:08:04ZTelomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia1178-2021https://doaj.org/article/59d7c1cbb96646d7b89dacac6e20fdbd2015-06-01T00:00:00Zhttp://www.dovepress.com/telomere-length-in-blood-cells-is-related-tonbspthenbspchronicity-seve-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tomasz Pawelczyk,1 Bozena Szymanska,2 Marta Grancow-Grabka,3 Magdalena Kotlicka-Antczak,1 Agnieszka Pawelczyk1 1Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka, Lodz, Poland; 2Central Scientific Laboratory, Medical University of Lodz, Mazowiecka, Lodz, Poland; 3Central Teaching Hospital, Medical University of Lodz, Czechoslowacka, Lodz, PolandIntroduction: Telomere shortening is strongly associated with higher mortality rates and has been shown in a number of age-related diseases, such as cardiovascular disorders, diabetes mellitus, Alzheimer’s disease, and psychiatric disorders. Oxidative stress is known to induce DNA breaks and genome instability. Telomeric DNA rich in guanosine is particularly sensitive to such oxidative damages. Psychosis is associated with a disequilibrium between free radical production and antioxidative defense. Although telomere attrition has been demonstrated in schizophrenia, no relationship has been reported between telomere length and severity of schizophrenia.Aim: The aim of the present study was to identify differences in telomere length in peripheral blood cells between patients with chronic schizophrenia (C-SCZ) and early schizophrenia (E-SCZ) and to identify any relationship between telomere length and disease chronicity and severity.Methods: Relative average telomere lengths were determined using qPCR assay in patients with E-SCZ (n=42) and C-SCZ (n=44) hospitalized due to schizophrenia exacerbation. E-SCZ was diagnosed when less than 2 years had passed since the beginning of psychotic symptoms. The severity of symptoms was assessed using appropriate scales.Results: The severity of schizophrenia symptoms, as well as the number of psychotic episodes and hospital admissions, correlated significantly with telomere length in univariate analyses. Regression analysis revealed that a model incorporating study group (E-SCZ or C-ECZ), sex, and age, as well as the combined number of documented psychotic episodes and hospital admissions, can significantly predict the length of telomeres in patients with schizophrenia, with over 50% of variance in telomere length explained by the model (adjusted R2=0.512).Conclusion: The results of the current study indicate that the recurrence of psychotic symptoms as well as their intensity and chronicity may be correlated with telomere attrition, which is well known to contribute to the development of premature senescence and age-related diseases.Keywords: telomere shortening, schizophrenia, exacerbation, agingPawelczyk TSzymanska BGrancow-Grabka MKotlicka-Antczak MPawelczyk ADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1493-1503 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Pawelczyk T
Szymanska B
Grancow-Grabka M
Kotlicka-Antczak M
Pawelczyk A
Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
description Tomasz Pawelczyk,1 Bozena Szymanska,2 Marta Grancow-Grabka,3 Magdalena Kotlicka-Antczak,1 Agnieszka Pawelczyk1 1Department of Affective and Psychotic Disorders, Medical University of Lodz, Czechoslowacka, Lodz, Poland; 2Central Scientific Laboratory, Medical University of Lodz, Mazowiecka, Lodz, Poland; 3Central Teaching Hospital, Medical University of Lodz, Czechoslowacka, Lodz, PolandIntroduction: Telomere shortening is strongly associated with higher mortality rates and has been shown in a number of age-related diseases, such as cardiovascular disorders, diabetes mellitus, Alzheimer’s disease, and psychiatric disorders. Oxidative stress is known to induce DNA breaks and genome instability. Telomeric DNA rich in guanosine is particularly sensitive to such oxidative damages. Psychosis is associated with a disequilibrium between free radical production and antioxidative defense. Although telomere attrition has been demonstrated in schizophrenia, no relationship has been reported between telomere length and severity of schizophrenia.Aim: The aim of the present study was to identify differences in telomere length in peripheral blood cells between patients with chronic schizophrenia (C-SCZ) and early schizophrenia (E-SCZ) and to identify any relationship between telomere length and disease chronicity and severity.Methods: Relative average telomere lengths were determined using qPCR assay in patients with E-SCZ (n=42) and C-SCZ (n=44) hospitalized due to schizophrenia exacerbation. E-SCZ was diagnosed when less than 2 years had passed since the beginning of psychotic symptoms. The severity of symptoms was assessed using appropriate scales.Results: The severity of schizophrenia symptoms, as well as the number of psychotic episodes and hospital admissions, correlated significantly with telomere length in univariate analyses. Regression analysis revealed that a model incorporating study group (E-SCZ or C-ECZ), sex, and age, as well as the combined number of documented psychotic episodes and hospital admissions, can significantly predict the length of telomeres in patients with schizophrenia, with over 50% of variance in telomere length explained by the model (adjusted R2=0.512).Conclusion: The results of the current study indicate that the recurrence of psychotic symptoms as well as their intensity and chronicity may be correlated with telomere attrition, which is well known to contribute to the development of premature senescence and age-related diseases.Keywords: telomere shortening, schizophrenia, exacerbation, aging
format article
author Pawelczyk T
Szymanska B
Grancow-Grabka M
Kotlicka-Antczak M
Pawelczyk A
author_facet Pawelczyk T
Szymanska B
Grancow-Grabka M
Kotlicka-Antczak M
Pawelczyk A
author_sort Pawelczyk T
title Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
title_short Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
title_full Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
title_fullStr Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
title_full_unstemmed Telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
title_sort telomere length in blood cells is related to the chronicity, severity, and recurrence rate of schizophrenia
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/59d7c1cbb96646d7b89dacac6e20fdbd
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AT szymanskab telomerelengthinbloodcellsisrelatedtonbspthenbspchronicityseverityandrecurrenceratenbspofnbspschizophrenia
AT grancowgrabkam telomerelengthinbloodcellsisrelatedtonbspthenbspchronicityseverityandrecurrenceratenbspofnbspschizophrenia
AT kotlickaantczakm telomerelengthinbloodcellsisrelatedtonbspthenbspchronicityseverityandrecurrenceratenbspofnbspschizophrenia
AT pawelczyka telomerelengthinbloodcellsisrelatedtonbspthenbspchronicityseverityandrecurrenceratenbspofnbspschizophrenia
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