ABO blood group antigen therapy: a potential new strategy against solid tumors

Abstract The economic burden of tumors is increasing, so there is an urgent need to develop new therapies for their treatment. Killing tumors by activating complement is an effective strategy for the treatment. We used the ABO blood group system and the corresponding antibodies to activate the kille...

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Autores principales:	Qiong Luo, Mingxin Pan, Hao Feng, Lei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59d7e2457e404c16a7f24c1c82d018ab
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spelling	oai:doaj.org-article:59d7e2457e404c16a7f24c1c82d018ab2021-12-02T16:27:50ZABO blood group antigen therapy: a potential new strategy against solid tumors10.1038/s41598-021-95794-x2045-2322https://doaj.org/article/59d7e2457e404c16a7f24c1c82d018ab2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95794-xhttps://doaj.org/toc/2045-2322Abstract The economic burden of tumors is increasing, so there is an urgent need to develop new therapies for their treatment. Killing tumors by activating complement is an effective strategy for the treatment. We used the ABO blood group system and the corresponding antibodies to activate the killer cell capacity of the complement system. After the construction of a mouse model containing blood group A antibodies and inoculating colorectal cancer and breast cancer cells into the axillae of the mice, intratumoural injection using a lentivirus carrying a blood group antigen as a drug significantly reduced the tumor volume of the mice. Compared with the control group, the content of the C5b-9 complement membrane attack complex in the tumors of mice treated with the blood group A antigen was significantly increased, and the proportion of NK cells was also significantly increased. In vitro cell-based experiments proved that tumor cells expressing blood group A antigens showed significantly inhibited cell proliferation when added to serum containing blood group A antibodies. These results all prove that the ABO blood group antigen may become a powerful tool for the treatment of tumors in patients.Qiong LuoMingxin PanHao FengLei WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qiong Luo Mingxin Pan Hao Feng Lei Wang ABO blood group antigen therapy: a potential new strategy against solid tumors
description	Abstract The economic burden of tumors is increasing, so there is an urgent need to develop new therapies for their treatment. Killing tumors by activating complement is an effective strategy for the treatment. We used the ABO blood group system and the corresponding antibodies to activate the killer cell capacity of the complement system. After the construction of a mouse model containing blood group A antibodies and inoculating colorectal cancer and breast cancer cells into the axillae of the mice, intratumoural injection using a lentivirus carrying a blood group antigen as a drug significantly reduced the tumor volume of the mice. Compared with the control group, the content of the C5b-9 complement membrane attack complex in the tumors of mice treated with the blood group A antigen was significantly increased, and the proportion of NK cells was also significantly increased. In vitro cell-based experiments proved that tumor cells expressing blood group A antigens showed significantly inhibited cell proliferation when added to serum containing blood group A antibodies. These results all prove that the ABO blood group antigen may become a powerful tool for the treatment of tumors in patients.
format	article
author	Qiong Luo Mingxin Pan Hao Feng Lei Wang
author_facet	Qiong Luo Mingxin Pan Hao Feng Lei Wang
author_sort	Qiong Luo
title	ABO blood group antigen therapy: a potential new strategy against solid tumors
title_short	ABO blood group antigen therapy: a potential new strategy against solid tumors
title_full	ABO blood group antigen therapy: a potential new strategy against solid tumors
title_fullStr	ABO blood group antigen therapy: a potential new strategy against solid tumors
title_full_unstemmed	ABO blood group antigen therapy: a potential new strategy against solid tumors
title_sort	abo blood group antigen therapy: a potential new strategy against solid tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59d7e2457e404c16a7f24c1c82d018ab
work_keys_str_mv	AT qiongluo abobloodgroupantigentherapyapotentialnewstrategyagainstsolidtumors AT mingxinpan abobloodgroupantigentherapyapotentialnewstrategyagainstsolidtumors AT haofeng abobloodgroupantigentherapyapotentialnewstrategyagainstsolidtumors AT leiwang abobloodgroupantigentherapyapotentialnewstrategyagainstsolidtumors
_version_	1718383992434065408

ABO blood group antigen therapy: a potential new strategy against solid tumors

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