SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway

The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 signalling axis, identifying potential therapeu...

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Autores principales:	Ning Xie, Min Chen, Rilei Dai, Yan Zhang, Hanqing Zhao, Zhiming Song, Lufeng Zhang, Zhenyan Li, Yuanqing Feng, Hua Gao, Li Wang, Ting Zhang, Rui-Ping Xiao, Jianxin Wu, Chun-Mei Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59d9007962e242c29fcd30bbb7973136
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spelling	oai:doaj.org-article:59d9007962e242c29fcd30bbb79731362021-12-02T15:38:36ZSRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway10.1038/ncomms160162041-1723https://doaj.org/article/59d9007962e242c29fcd30bbb79731362017-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms16016https://doaj.org/toc/2041-1723The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 signalling axis, identifying potential therapeutic targets for vascular proliferative disorders.Ning XieMin ChenRilei DaiYan ZhangHanqing ZhaoZhiming SongLufeng ZhangZhenyan LiYuanqing FengHua GaoLi WangTing ZhangRui-Ping XiaoJianxin WuChun-Mei CaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ning Xie Min Chen Rilei Dai Yan Zhang Hanqing Zhao Zhiming Song Lufeng Zhang Zhenyan Li Yuanqing Feng Hua Gao Li Wang Ting Zhang Rui-Ping Xiao Jianxin Wu Chun-Mei Cao SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
description	The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 signalling axis, identifying potential therapeutic targets for vascular proliferative disorders.
format	article
author	Ning Xie Min Chen Rilei Dai Yan Zhang Hanqing Zhao Zhiming Song Lufeng Zhang Zhenyan Li Yuanqing Feng Hua Gao Li Wang Ting Zhang Rui-Ping Xiao Jianxin Wu Chun-Mei Cao
author_facet	Ning Xie Min Chen Rilei Dai Yan Zhang Hanqing Zhao Zhiming Song Lufeng Zhang Zhenyan Li Yuanqing Feng Hua Gao Li Wang Ting Zhang Rui-Ping Xiao Jianxin Wu Chun-Mei Cao
author_sort	Ning Xie
title	SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
title_short	SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
title_full	SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
title_fullStr	SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
title_full_unstemmed	SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
title_sort	srsf1 promotes vascular smooth muscle cell proliferation through a δ133p53/egr1/klf5 pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/59d9007962e242c29fcd30bbb7973136
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SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway

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