Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report

Abstract Background Subacute combined degeneration (SCD) is a neurological complication commonly associated with vitamin B12 deficiency. It can result from nitrous oxide (N2O) abuse and cause neuropsychiatric symptoms. However, there has been no literature regarding alterations of serum copper and c...

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Autores principales:	Jie Cao, Lusen Ran, Chenchen Liu, Zhijun Li
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Nitrous oxide Subacute combined degeneration Serum copper Cerebellar atrophy Cognitive decline Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/59d917f62a3b485192fc81965f4aad30
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spelling	oai:doaj.org-article:59d917f62a3b485192fc81965f4aad302021-12-05T12:08:49ZSerum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report10.1186/s12883-021-02496-y1471-2377https://doaj.org/article/59d917f62a3b485192fc81965f4aad302021-12-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02496-yhttps://doaj.org/toc/1471-2377Abstract Background Subacute combined degeneration (SCD) is a neurological complication commonly associated with vitamin B12 deficiency. It can result from nitrous oxide (N2O) abuse and cause neuropsychiatric symptoms. However, there has been no literature regarding alterations of serum copper and cerebellum in SCD patients. Case presentation We reported two cases of young SCD patients with histories of N2O abuse. In these cases, elevated homocysteine, macrocytic anemia, spinal cord abnormalities, and peripheral nerve injuries were detected. In addition, decreased serum copper level and cerebellar atrophy were reported for the first time. The patients’ symptoms improved after withdrawal of N2O exposure and vitamin B12 supplements. Conclusion We reported two SCD cases with serum copper alteration and cerebellar atrophy after N2O abuse for the first time. These might be crucial complements to the diagnosis of SCD.Jie CaoLusen RanChenchen LiuZhijun LiBMCarticleNitrous oxideSubacute combined degenerationSerum copperCerebellar atrophyCognitive declineNeurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nitrous oxide Subacute combined degeneration Serum copper Cerebellar atrophy Cognitive decline Neurology. Diseases of the nervous system RC346-429
spellingShingle	Nitrous oxide Subacute combined degeneration Serum copper Cerebellar atrophy Cognitive decline Neurology. Diseases of the nervous system RC346-429 Jie Cao Lusen Ran Chenchen Liu Zhijun Li Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
description	Abstract Background Subacute combined degeneration (SCD) is a neurological complication commonly associated with vitamin B12 deficiency. It can result from nitrous oxide (N2O) abuse and cause neuropsychiatric symptoms. However, there has been no literature regarding alterations of serum copper and cerebellum in SCD patients. Case presentation We reported two cases of young SCD patients with histories of N2O abuse. In these cases, elevated homocysteine, macrocytic anemia, spinal cord abnormalities, and peripheral nerve injuries were detected. In addition, decreased serum copper level and cerebellar atrophy were reported for the first time. The patients’ symptoms improved after withdrawal of N2O exposure and vitamin B12 supplements. Conclusion We reported two SCD cases with serum copper alteration and cerebellar atrophy after N2O abuse for the first time. These might be crucial complements to the diagnosis of SCD.
format	article
author	Jie Cao Lusen Ran Chenchen Liu Zhijun Li
author_facet	Jie Cao Lusen Ran Chenchen Liu Zhijun Li
author_sort	Jie Cao
title	Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
title_short	Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
title_full	Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
title_fullStr	Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
title_full_unstemmed	Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
title_sort	serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/59d917f62a3b485192fc81965f4aad30
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Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report

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