Cellular senescence drives age-dependent hepatic steatosis

Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in old, obese or diabetic mice.

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Autores principales:	Mikolaj Ogrodnik, Satomi Miwa, Tamar Tchkonia, Dina Tiniakos, Caroline L. Wilson, Albert Lahat, Christoper P. Day, Alastair Burt, Allyson Palmer, Quentin M. Anstee, Sushma Nagaraja Grellscheid, Jan H J. Hoeijmakers, Sander Barnhoorn, Derek A. Mann, Thomas G. Bird, Wilbert P. Vermeij, James L. Kirkland, João F. Passos, Thomas von Zglinicki, Diana Jurk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/59da7366bd92469288a45b90a4b396f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:59da7366bd92469288a45b90a4b396f92021-12-02T17:06:10ZCellular senescence drives age-dependent hepatic steatosis10.1038/ncomms156912041-1723https://doaj.org/article/59da7366bd92469288a45b90a4b396f92017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15691https://doaj.org/toc/2041-1723Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in old, obese or diabetic mice.Mikolaj OgrodnikSatomi MiwaTamar TchkoniaDina TiniakosCaroline L. WilsonAlbert LahatChristoper P. DayAlastair BurtAllyson PalmerQuentin M. AnsteeSushma Nagaraja GrellscheidJan H J. HoeijmakersSander BarnhoornDerek A. MannThomas G. BirdWilbert P. VermeijJames L. KirklandJoão F. PassosThomas von ZglinickiDiana JurkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mikolaj Ogrodnik Satomi Miwa Tamar Tchkonia Dina Tiniakos Caroline L. Wilson Albert Lahat Christoper P. Day Alastair Burt Allyson Palmer Quentin M. Anstee Sushma Nagaraja Grellscheid Jan H J. Hoeijmakers Sander Barnhoorn Derek A. Mann Thomas G. Bird Wilbert P. Vermeij James L. Kirkland João F. Passos Thomas von Zglinicki Diana Jurk Cellular senescence drives age-dependent hepatic steatosis
description	Non-alcoholic fatty liver disease is more common among older individuals. Here, the authors show that senescent cells in the liver promote fat accumulation and steatosis in the liver, and that clearance of senescent cells reduces hepatic steatosis in old, obese or diabetic mice.
format	article
author	Mikolaj Ogrodnik Satomi Miwa Tamar Tchkonia Dina Tiniakos Caroline L. Wilson Albert Lahat Christoper P. Day Alastair Burt Allyson Palmer Quentin M. Anstee Sushma Nagaraja Grellscheid Jan H J. Hoeijmakers Sander Barnhoorn Derek A. Mann Thomas G. Bird Wilbert P. Vermeij James L. Kirkland João F. Passos Thomas von Zglinicki Diana Jurk
author_facet	Mikolaj Ogrodnik Satomi Miwa Tamar Tchkonia Dina Tiniakos Caroline L. Wilson Albert Lahat Christoper P. Day Alastair Burt Allyson Palmer Quentin M. Anstee Sushma Nagaraja Grellscheid Jan H J. Hoeijmakers Sander Barnhoorn Derek A. Mann Thomas G. Bird Wilbert P. Vermeij James L. Kirkland João F. Passos Thomas von Zglinicki Diana Jurk
author_sort	Mikolaj Ogrodnik
title	Cellular senescence drives age-dependent hepatic steatosis
title_short	Cellular senescence drives age-dependent hepatic steatosis
title_full	Cellular senescence drives age-dependent hepatic steatosis
title_fullStr	Cellular senescence drives age-dependent hepatic steatosis
title_full_unstemmed	Cellular senescence drives age-dependent hepatic steatosis
title_sort	cellular senescence drives age-dependent hepatic steatosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/59da7366bd92469288a45b90a4b396f9
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Cellular senescence drives age-dependent hepatic steatosis

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