Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations

Abstract Given the fact that threatened species are often composed of isolated small populations, spatial continuity or demography of the populations may be major factors that have shaped the species’ genetic diversity. Thus, neutral loci have been the most commonly-used markers in conservation gene...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hari Won, Hyung-Bae Jeon, Dong-Young Kim, Ho Young Suk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/59dd752d510f4e3fb271468b0dd5164f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:59dd752d510f4e3fb271468b0dd5164f
record_format	dspace
spelling	oai:doaj.org-article:59dd752d510f4e3fb271468b0dd5164f2021-12-02T17:06:31ZDifferential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations10.1038/s41598-021-95385-w2045-2322https://doaj.org/article/59dd752d510f4e3fb271468b0dd5164f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95385-whttps://doaj.org/toc/2045-2322Abstract Given the fact that threatened species are often composed of isolated small populations, spatial continuity or demography of the populations may be major factors that have shaped the species’ genetic diversity. Thus, neutral loci have been the most commonly-used markers in conservation genetics. However, the populations under the influence of different environmental factors may have evolved in response to different selective pressures, which cannot be fully reflected in neutral genetic variation. Rhodeus pseudosericeus, a bitterling species (Acheilognathidae; Cypriniformes) endemic to the Korean Peninsula, are only found in some limited areas of three rivers, Daecheon, Han and Muhan, that flow into the west coast. Here, we genotyped 24 microsatellite loci and two loci (DAB1 and DAB3) of MHC class II peptide-binding β1 domain for 222 individuals collected from seven populations. Our microsatellite analysis revealed distinctive differentiation between the populations of Daecheon and Muhan Rivers and the Han River populations, and populations were structured into two subgroups within the Han River. Apparent positive selection signatures were found in the peptide-binding residues (PBRs) of the MHC loci. The allelic distribution of MHC showed a degree of differentiation between the populations of Daecheon and Muhan Rivers and the Han River populations, partially similar to the results obtained for microsatellites, however showed rather complex patterns among populations in the Han River. Considering the apparent differences in the distribution of supertypes obtained based on the physicochemical differences induced by the polymorphisms of these PBRs, the differentiation in DAB1 between the two regional groups may result in the differences in immune function. No differentiation between these two regions was observed in the supertyping of DAB3, probably indicating that only DAB1 was associated with the response to locally specialized antigenic peptides.Hari WonHyung-Bae JeonDong-Young KimHo Young SukNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hari Won Hyung-Bae Jeon Dong-Young Kim Ho Young Suk Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations
description	Abstract Given the fact that threatened species are often composed of isolated small populations, spatial continuity or demography of the populations may be major factors that have shaped the species’ genetic diversity. Thus, neutral loci have been the most commonly-used markers in conservation genetics. However, the populations under the influence of different environmental factors may have evolved in response to different selective pressures, which cannot be fully reflected in neutral genetic variation. Rhodeus pseudosericeus, a bitterling species (Acheilognathidae; Cypriniformes) endemic to the Korean Peninsula, are only found in some limited areas of three rivers, Daecheon, Han and Muhan, that flow into the west coast. Here, we genotyped 24 microsatellite loci and two loci (DAB1 and DAB3) of MHC class II peptide-binding β1 domain for 222 individuals collected from seven populations. Our microsatellite analysis revealed distinctive differentiation between the populations of Daecheon and Muhan Rivers and the Han River populations, and populations were structured into two subgroups within the Han River. Apparent positive selection signatures were found in the peptide-binding residues (PBRs) of the MHC loci. The allelic distribution of MHC showed a degree of differentiation between the populations of Daecheon and Muhan Rivers and the Han River populations, partially similar to the results obtained for microsatellites, however showed rather complex patterns among populations in the Han River. Considering the apparent differences in the distribution of supertypes obtained based on the physicochemical differences induced by the polymorphisms of these PBRs, the differentiation in DAB1 between the two regional groups may result in the differences in immune function. No differentiation between these two regions was observed in the supertyping of DAB3, probably indicating that only DAB1 was associated with the response to locally specialized antigenic peptides.
format	article
author	Hari Won Hyung-Bae Jeon Dong-Young Kim Ho Young Suk
author_facet	Hari Won Hyung-Bae Jeon Dong-Young Kim Ho Young Suk
author_sort	Hari Won
title	Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations
title_short	Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations
title_full	Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations
title_fullStr	Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations
title_full_unstemmed	Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations
title_sort	differential patterns of diversity at neutral and adaptive loci in endangered rhodeus pseudosericeus populations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/59dd752d510f4e3fb271468b0dd5164f
work_keys_str_mv	AT hariwon differentialpatternsofdiversityatneutralandadaptivelociinendangeredrhodeuspseudosericeuspopulations AT hyungbaejeon differentialpatternsofdiversityatneutralandadaptivelociinendangeredrhodeuspseudosericeuspopulations AT dongyoungkim differentialpatternsofdiversityatneutralandadaptivelociinendangeredrhodeuspseudosericeuspopulations AT hoyoungsuk differentialpatternsofdiversityatneutralandadaptivelociinendangeredrhodeuspseudosericeuspopulations
_version_	1718381554210701312

Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations

Ejemplares similares