Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant

Humans are the most crucial host of Salmonella typhi as it has limited ability to reproduce outside the human body. S. typhi infections caused typhoid fever which can be prevented with vaccines. This study aims to develop an effective typhoid fever oral vaccine using a liposomal delivery system. Sev...

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Autores principales:	Hidajah Rachmawati, Raditya Weka Nugraheni, Firasti Agung Nugrahening Sumadi, Helmy Yusuf
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Ahmad Dahlan 2021
Materias:	liposome adho36 β-glucan salmonella typhi oral vaccine dimethyl dioctadecyl ammonium bromide (ddab) cationic liposome Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/59ddecb6574648c482725ea7f510d294
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spelling	oai:doaj.org-article:59ddecb6574648c482725ea7f510d2942021-11-17T06:55:39Z Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant10.12928/pharmaciana.v11i3.192642088-45592477-0256https://doaj.org/article/59ddecb6574648c482725ea7f510d2942021-11-01T00:00:00Zhttp://journal.uad.ac.id/index.php/PHARMACIANA/article/view/19264/pdf_210https://doaj.org/toc/2088-4559https://doaj.org/toc/2477-0256Humans are the most crucial host of Salmonella typhi as it has limited ability to reproduce outside the human body. S. typhi infections caused typhoid fever which can be prevented with vaccines. This study aims to develop an effective typhoid fever oral vaccine using a liposomal delivery system. Several studies showed that the immunization of AdhO36 protein from S. typhi orally provides significant protection in inhibiting the S. typhi to the mice intestine. β-Glucan is a potent immunostimulant for macrophages activations. Meanwhile, the method used to produce Liposome formulations was using thin-film hydration. The liposomal products had good characteristics based on their particle size. The particle size results met the requirement for optimum intestinal absorption 399.220+28.095 nm Liposome+AdhO36 and 383.360+8.594 nm Liposome+β-glucan. Based on the zeta potential measurement, the electrical charges of the three formulations were positive, meaning that the liposome is cationic because of the DDAB (dimethyl dioctadecyl ammonium bromide) component. The positive charge will facilitate the internalization of antigen to the immunity cells.Hidajah RachmawatiRaditya Weka NugraheniFirasti Agung Nugrahening Sumadi Helmy YusufUniversitas Ahmad Dahlanarticleliposomeadho36β-glucansalmonella typhioral vaccinedimethyl dioctadecyl ammonium bromide (ddab)cationic liposomePharmacy and materia medicaRS1-441ENPharmaciana, Vol 11, Iss 3, Pp 376-384 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	liposome adho36 β-glucan salmonella typhi oral vaccine dimethyl dioctadecyl ammonium bromide (ddab) cationic liposome Pharmacy and materia medica RS1-441
spellingShingle	liposome adho36 β-glucan salmonella typhi oral vaccine dimethyl dioctadecyl ammonium bromide (ddab) cationic liposome Pharmacy and materia medica RS1-441 Hidajah Rachmawati Raditya Weka Nugraheni Firasti Agung Nugrahening Sumadi Helmy Yusuf Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant
description	Humans are the most crucial host of Salmonella typhi as it has limited ability to reproduce outside the human body. S. typhi infections caused typhoid fever which can be prevented with vaccines. This study aims to develop an effective typhoid fever oral vaccine using a liposomal delivery system. Several studies showed that the immunization of AdhO36 protein from S. typhi orally provides significant protection in inhibiting the S. typhi to the mice intestine. β-Glucan is a potent immunostimulant for macrophages activations. Meanwhile, the method used to produce Liposome formulations was using thin-film hydration. The liposomal products had good characteristics based on their particle size. The particle size results met the requirement for optimum intestinal absorption 399.220+28.095 nm Liposome+AdhO36 and 383.360+8.594 nm Liposome+β-glucan. Based on the zeta potential measurement, the electrical charges of the three formulations were positive, meaning that the liposome is cationic because of the DDAB (dimethyl dioctadecyl ammonium bromide) component. The positive charge will facilitate the internalization of antigen to the immunity cells.
format	article
author	Hidajah Rachmawati Raditya Weka Nugraheni Firasti Agung Nugrahening Sumadi Helmy Yusuf
author_facet	Hidajah Rachmawati Raditya Weka Nugraheni Firasti Agung Nugrahening Sumadi Helmy Yusuf
author_sort	Hidajah Rachmawati
title	Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant
title_short	Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant
title_full	Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant
title_fullStr	Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant
title_full_unstemmed	Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant
title_sort	formulations of liposomal vaccine containing adho36 antigen and β-glucan as immunoadjuvant
publisher	Universitas Ahmad Dahlan
publishDate	2021
url	https://doaj.org/article/59ddecb6574648c482725ea7f510d294
work_keys_str_mv	AT hidajahrachmawati formulationsofliposomalvaccinecontainingadho36antigenandbglucanasimmunoadjuvant AT radityawekanugraheni formulationsofliposomalvaccinecontainingadho36antigenandbglucanasimmunoadjuvant AT firastiagungnugraheningsumadi formulationsofliposomalvaccinecontainingadho36antigenandbglucanasimmunoadjuvant AT helmyyusuf formulationsofliposomalvaccinecontainingadho36antigenandbglucanasimmunoadjuvant
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Formulations of liposomal vaccine containing AdhO36 antigen and β-glucan as immunoadjuvant

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